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Abstract  

Differential scanning microcalorimetry (DSC) and UV–VIS absorption spectroscopy were used to obtain the characteristics of blood serum from newborn rat’ after maternal treatment with cyclophosphamide in comparison with control. The obtained DSC curves reveal a complex endothermic peak due to the unfolding process of various serum proteins. Thermal profiles and absorption spectra of blood serum are sensitive to the age of newborns as well as to effect of maternal administration of cyclophosphamide. The most significant disturbances in serum proteome were observed for 14-day old newborns. The thermodynamic parameters: enthalpy change (∆H), the normalized first moment (M1) of the thermal transition with respect to the temperature axis and the ratio of C p ex at 70 and 60 °C describing denaturation contributions of globulin forms in respect to unliganded albumin with haptoglobin was estimated. Moreover, the second derivative spectroscopy in the UV region was used to resolve the complex protein spectrum. The differences in blood serum detected by DSC and UV–VIS confirm a potential usefulness of these methods for diagnostic and monitoring changes with age as well as the pathological state of blood serum.

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Acta Veterinaria Hungarica
Authors: L'. Leng, M. Štefkovič, Viera Révajová, - Halanová, and M. Horváth

Levkut, M. (1981): Effect of cyclophosphamide on avian sarcoma infected rats. In: M. Levkut (ed.) Pathomorphological Study of Avian Sarcomatosis (in Slovak). PhD Thesis, University of Veterinary Medicine, Ko.ice, pp. 105

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Beyer-Boon, M. E., De Voogt, H. J. and Schaberg, A. (1978): The effects of cyclophosphamide treatment on the epithelium and stroma of the urinary bladder. Eur. J. Cancer 14 , 1029

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fludarabine and cyclophosphamide and high dose rituximab in previously untreated patients with chronic lymphocytic leukemia. J. Clin. Oncol., 2009, 27 , 498–503. Land S. R

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Magyar Sebészet
Authors: Péter Járomi, Andrea Szabó, Dénes Garab, Dóra Bodnár, Gabriella Uhercsák, Mihály Boros, and Petra Hartmann

Nicotinic signaling ameliorates acute bladder inflammation induced by protamine sulfate or cyclophosphamide J Urol 179 6 2440 6 . 3

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.: Distal acquired demyelinating symmetric polyneuropathy progressing to classic chronic inflammatory demyelinating polyneuropathy and response to fludarabine and cyclophosphamide. Muscle Nerve, 2013, 47 , 292

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Orvosi Hetilap
Authors: Márk Plander, Judit Skrapits, Tünde Bozsó, Tamás Szendrei, and János László Iványi

1165 1171 Eichhorst, B. F., Busch, R., Hopfinger, G., et al.: Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients

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nephritis: the Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide. Arthritis Rheum., 2002, 46 (8), 2121–2131. 25

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Orvosi Hetilap
Authors: Renáta Nyilas, Borbála Székely, László Váróczy, Zsófia Simon, Anita Árokszállási, Árpád Illés, and Lajos Gergely

–86. Dearden, C., Wade, R., Else, M., et al.: The prognostic significance of a positive direct antiglobulin test in chronic lymphocytic leukemia: a beneficial effect of the combination of fludarabine and cyclophosphamide on the incidence of hemolytic anemia

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was gradually decreased over 5–6 months to the maintenance of 4 mg given daily or every other day. Cyclophosphamide (CYC) in a dose of 9–11 mg/kg depending on age and renal function was administered in monthly IV boluses six times, than repeated at

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