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Introduction Cytokines are secreted mostly by cells of the immune system. They are small regulatory proteins that participate in anti-inflammatory and pro-inflammatory processes in the body. Cytokines and their soluble

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Journal of Thermal Analysis and Calorimetry
Authors: Susan Moreno-Molek, Salaam Saleh, Druthiman Reddy Mantheni, Manik Pavan Kumar Maheswaram, Tobili Sam-Yellowe, and Alan T. Riga

Introduction In an ongoing series of studies to understand the thermal analytical behavior of cytokines and their receptors, the cytokines; (IFNγ, TNFα, IL-1α, IL-2, IL-4, IL-6, IL-10), and soluble receptors and antagonists

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Journal of Radioanalytical and Nuclear Chemistry
Authors: J. Baptista, D. Vieira, A. Galisteo Júnior, O. Higa, M. Casare, C. Yonamine, P. Caproni, L. Campos, H. de Andrade Júnior, P. Spencer, and N. Nascimento

Abstract  

In this work, the authors investigated the immunological behavior of bothropstoxin-I (BTHX-1), before and after irradiation process, and also the influence of scavengers substances on protein alterations induced by free radical production. Structural modifications were investigated by SDS-PAGE in reducing or non-reducing conditions. In vitro cytotoxicity assay was performed to test average toxic activities of BTHX-I. BALB/c Isogenic mice were immunized with irradiated or non-irradiated (native) forms of BTHX-I and antibody titers and isotypes were determined by ELISA method. Expression of murine cytokines was analyzed by using expression data obtained by quantitative real-time PCR (qPCR) assays. The results indicate that irradiation of proteins leads to significant structural modifications, and also changes the cytokines profile during immunization process, regarding a suitable approach to new immunogenic production.

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. Acta Microbiol Hung 37 351 Megyeri, K., Mándi, Y., Degré, M., Rosztóczy, I.: Induction of cytokine production by

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Cao, X. Y., Dong, M., Shen, J. Z., Wu, B. B., Wu, C. M., Du, X. D., Wang, Z., Qi, Y. T. and Li, B. Y. (2006): Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS

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, 2012 , pp. 38 , 50. 2. Dinarello , C. A. : Proinflammatory cytokines. Chest Journal 9 , 503 – 508 ( 2000 ). 3

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. , Punnonen , J. , Aversa , G. , Sato , A. , Dang , W. , Cocks , B. G. , Menon , S. , et al. : Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function . Proc Natl Acad Sci U S A 90 , 3735 – 3739 ( 1993

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response may indicate different consequences of the infection by this organism [ 3 ]. Several previous studies on the patient with H. pylori infection reported an increase in the proinflammatory cytokines of TNF-α, IL-1β, IL-1RN, IL-8, and IL-10 in

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abnormalities in the circadian rhythm, increased inflammatory cytokines, hypercortisolemia, and deficiency of monoamines. It has also been suggested that oxidative stress is increased in patients with depression ( 4 , 28 ). Moreover, many studies have shown

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abnormalities in the circadian rhythm, increased inflammatory cytokines, hypercortisolemia, and deficiency of monoamines. It has also been suggested that oxidative stress is increased in patients with depression ( 4 , 28 ). Moreover, many studies have shown

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