Search Results

You are looking at 1 - 10 of 186 items for :

Clear All
Journal of Behavioral Addictions
Authors: Fatih Canan, Servet Karaca, Melike Düzgün, Ayşe Merve Erdem, Esranur Karaçaylı, Nur Begüm Topan, Sang-Kyu Lee, Zu Wei Zhai, Murat Kuloğlu and Marc N. Potenza

Introduction The ratio of second-to-fourth digit length (2D:4D ratio) is determined during the fetal period and becomes stable across the lifespan starting at 2 years of age ( Manning, Trivers, Thornhill, & Singh, 2000

Open access

Abstract  

The reaction of13N to form13N-labelled compounds was studied in acetic acid-d4 as a function of the halogenoacetic acid concentration and in malonic acid-d4 as a function of the intermolecular distance of target malonic acid-d4 at 195 and 295±6 K. In both deuterated carboxylic acids,13N atoms were found in several forms in the order of radiochemical yields,13NH3>H13NO3>[13N]aminoacid>HC13N. The yield of [13N]glycine formed in acetic acid-d4 were markedly enhanced by iodoacetic acid and slightly by chloroacetic acid. In malonic acid-d4, the yield of13NH3 was directly proportional to the cubic root of the molar ratio, {D2O/CD2 (COOD)2}, while the yields of H13N3, [13N]aminomalonic acid and HC13N were inversely proportional to the cubic root of the molar ratio. The mechanism of the formation of the13N-compounds are discussed.

Restricted access
Journal of Radioanalytical and Nuclear Chemistry
Authors: Gu-Cai Li, Duan-Zhi Yin, Deng-Feng Cheng, Ming-Qiang Zheng, Yan-Jiang Han, Han-Chen Cai, Jiao-Yun Xia, Sheng Liang, Wan-Bang Xu and Yong-Xian Wang

Abstract  

3-(4-[18F]fluorobenzyl)-8-hydroxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one ([18F]FHTP) was in vitro and in vivo evaluated as a putative dopamine D4 receptor radioligand. Its inhibition constant (K i) for cloned human dopamine D4.2 receptor was determined to be 2.9 nM and it displayed a 2000-fold D4-selectivity over the D2long subtype. Its partition coefficient (logP) was measured to be 1.11. Biodistribution, blocking distribution and metabolism studies in rats demonstrated that the specific distribution of [18F]FHTP in brain regions, suggesting that [18F]FHTP may be a suitable PET imaging agent for in vivo studies of the dopamine D4 receptor.

Restricted access

In order to clarify the role of Pl PMI3 resistance gene in sunflower differential lines D4 for differentiation the pathogenicity in Plasmopara halstedii (sunflower downy mildew), analyses were carried out in two groups including four pathotypes which overcome and do not overcome Pl PMI3 (Pl gene has still not been mapped) resistance gene. Based on the reaction for the P. halstedii isolates to sunflower hybrids varying only in Pl resistance genes, there were no virulence differences for the two groups. Index of aggressiveness was calculated for pathogen isolates and revealed the presence of significant differences between isolates of races 304 and 314; however, there were no aggressiveness differences for 7xx races. Regarding the life-history trait and the genetic architecture of the pathogen: there were morphological and genetic variations for the four P. halstedii isolates without a correlation with pathogenic diversity. The importance of the Pl PMI3 resistance gene to differentiate the pathogenicity in sunflower downy mildew was discussed.

Restricted access

Abstract  

The compound 3-{[4-(4-[18F]fluorophenyl)methyl]piperazin-1-yl}-methyl-1H-pyrrolo[2,3-b]pyridine ([18F]3), which is an analogue of L-745,870 binding D4

Restricted access

Are there any long standing benefits in international equity investing? Did the acceleration of global financial integration bring clearly measurable benefits to international equity investors? Is there a convergence of equity market profitability around the world? These are the main questions of this paper. All of these questions got an affirmative answer, but, as it may be immediately suspected, many durable qualifiers and caveats apply. Section 1 reviews some key propositions of modern investment theory and some recent evidence on the benefits of international asset allocation on equity markets. It is argued that the desired benefits — as predicted by theory — can be and have been captured in terms of better risk/return trade-offs due to international diversification of equity portfolios. Manifest benefits aside, however, many dampening factors come into play when considering long term capacities of realising these benefits. Mainly the changing correlation structure of global markets and the increased currency risk, which still remained very difficult to hedge, were identified as permanent factors to limit the power of international diversification in pushing out the efficient frontier of the equity set. Section 2 presents comparative evidence on global equity markets’ performance and gives an account of the wide variations in the US dollar denominated returns of major markets, developed and emerging. There is some support to the view that a certain convergence can be depicted in the profitability levels of different markets. Exchange rate movements, however, accounted for almost one third of variations in profitability on average. As of April 2007, stock market valuations did favour emerging markets (and to some extent EU-27) when compared to Japan or the US.

Restricted access

Background and aims

“Study addiction” has recently been conceptualized as a behavioral addiction and defined within the framework of work addiction. Using a newly developed measure to assess this construct, the Bergen Study Addiction Scale (BStAS), the present study examined the 1-year stability of study addiction and factors related to changes in this construct over time, and is the first longitudinal investigation of study addiction thus far.

Methods

The BStAS and the Ten Item Personality Inventory were administered online together with questions concerning demographics and study-related variables in two waves. In Wave 1, a total of 2,559 students in Norway and 2,177 students in Poland participated. A year later, in Wave 2, 1,133 Norwegians and 794 Polish, who were still students completed the survey.

Results

The test–retest reliability coefficients for the BStAS revealed that the scores were relatively stable over time. In Norway, scores on the BStAS were higher in Wave 2 than in Wave 1, whereas in Poland, the reverse pattern was observed. Learning time outside classes at Wave 1 was positively related to escalation of study addiction symptoms over time in both samples. Being female and scoring higher on neuroticism was related to an increase in study addiction in the Norwegian sample only.

Conclusions

Study addiction appears to be temporally stable, and the amount of learning time spent outside classes predicts changes in study addiction 1 year later.

Open access

This study aims to evaluate the effect of anti-Streptococcus mutans IgY gel on quantity of S. mutans on rats’ tooth surface. Sprague Dawley rats were exposed intra-orally with S. mutans Xc and were fed a caries-inducing diet 2000. The 24 rats were divided into four groups: group A had their teeth coated with IgY gel; group B received sterilized water as a control; group C had their teeth coated with IgY gel starting on the 29th day; and group D had their teeth coated with a gel without IgY. Plaque samples were swabbed from the anterior teeth for S. mutans colony quantification, and saliva was collected to measure immunoreactivity by enzyme-linked immunosorbent assay. The results indicated that the quantity of S. mutans in rats treated with IgY gel showed significant difference compared with the controls. After coating with IgY anti-S. mutans gel, the mean immunoreactivity in rat saliva was higher than that of the no treatment group. In conclusion, topical application with anti-S. mutans IgY gel reduced the quantity of S. mutans on the tooth surface.

Open access

Since the first publication of Economics of Shortage in 1980, an entire economist generation has grown up, whose members are well-versed in numerous sub-themes of the economic sciences. They find their way around the most modern methodological schools, yet they know significantly less about the workings of the social systems. To the younger generations, the socialist system, whose heritage still lives with us and whose characteristic behavioural forms and attitudes have not yet disappeared at all from the economic practices of the post-socialist countries, seems like the distant past, just like the Turkish occupation or the Austro-Hungarian Monarchy.The target audience of Kalligram Publishing House is this generation, to the majority of whom János Kornai’s works will probably come as a revelation. The years of crisis — whose end is still far off — has made even those uncertain about the workings of economic systems, who have personal experiences of the decades of socialism. Therefore, it would be quite important for them to re-read Kornai’s works written during the socialist era in order to be able to grasp the workings of economic systems through the help of balanced and objective analyses. Moving beyond the momentary shocks and nostalgias, the older ones also have a great need to evaluate the roles of the market and the state in a bias-free manner resting on a solid theoretical foundation, to realistically see the mechanisms of shortage and surplus economies. This way it is perhaps possible to avoid “going down the same river twice”, which disappears somewhere underground and never reaches the sea.

Restricted access

Van der Maarel, S., Frants, R. R.: The D4Z4 repeat-mediated pathogenesis of facioscapulohumeral muscular dystrophy. Am. J. Hum. Genet., 2005, 76 , 375–386. Frants R. R. The D4Z4

Open access