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functions of regulating the human immunity, inhibiting the proliferation of lymphocyte, anti-inflammatory, liver-protection [ 1 – 4 ], anti-virus, anti-tumor [ 5 , 6 ], and so on. But, few studies have been done on the dissolution properties of this type of
as RDX and HMX. Its preparation [ 2 , 3 ], properties [ 4 , 5 ], and thermal behavior [ 6 , 7 ] have been reported widely. In the present article, we reported its enthalpy of dissolution in ethyl acetate and acetone, and four kinds of
Introduction The aqueous solubility and the dissolution rate of the drug from oral solid dosage forms have a relevant impact on the bioavailability of the active ingredient. Nifluminic acid (NIF), a structural analog of
Abstract
Bench scale experiments were conducted to determine the dissolution characteristics of UO2, U3O8, and UO3 in aqueous peroxide-containing carbonate solutions. The experimental parameters investigated included carbonate countercation (NH4 +, Na+, K+, and Rb+) and H2O2 concentration. The carbonate countercation had a dramatic influence on the dissolution behavior of UO2 in 1 M carbonate solutions containing 0.1 M H2O2, with the most rapid dissolution occurring in (NH4)2CO3 solution. The initial dissolution rate (y) of UO2 in 1 M (NH4)2CO3 increased linearly with peroxide concentration (x) ranging from 0.05 to 2 M according to: y = 2.41x + 1.14. The trend in initial dissolution rates for the three U oxides under study was UO3 ≫ U3O8 > UO2.
Abstract
Supercritical CO2 assisted dissolution of metals and metal-oxides and in situ extraction by TBP (or co-solvent) has been reported in literature. However, in this work, the dissolution and in situ extraction by nitric acid solvates of TBP and alternate solvent TiAP has been reported for g-level UO2 (essentially PHWR fuel pellet fragments) feeds at atmospheric pressure without requiring supercritical fluids. Encouraging results were obtained.
496-2000 Calvet microcalorimeter. The aim of this work is to study the dissolution properties of DTAED in DMSO and NMP. At the same time, the kinetic equations of the two dissolution processes are obtained, respectively, which provides valuable
, the most probable substitutions in this kind of products are couple substitutions (CO 3 2− , F − ) for PO 4 3− and (2CO 3 2− , V ca ) for 2PO 4 3− . In a previous paper, performed on the thermochemical aspect of the dissolution of synthetic
]. Nevertheless, it seems that polymorphism of aspirin is not commonly acknowledged at present [ 9 ]. The aqueous solubility behavior of a drug is a key determinant of its oral delivery. Poor water solubility and slow dissolution are often the main reasons
) [9] J. W. More and H. H. Flanner , Pharm. Technol. , 20 , 64 – 74 ( 1996 ) [10] FDA, Guidance for Industry: Dissolution
Abstract
In order to study the dissolution behavior of a highly burnt LWR fuel, a fuel pin irradiated in the DR3 test reactor in Risoe National Laboratory, has been characterized by microstructural examination and then dissolved under PUREX type conditions. The dissolution behavior was investigated and the residues analyzed by scanning electron microscopy and by ICP-MS and IDMS after dissolution.
