Authors:Máté Szász, Mária Hajdú, Natasa Pesti, Mónika Domahidy, Katalin Kristóf, ákos Zahár, Károly Nagy, and Dóra Szabó
Biofilm-forming Staphylococcus epidermidis strains are common cause of the periprosthetic infection. The treatment of the periprosthetic infection is very problematic, so the prevention of these infections by an antibiotic containing prothesis could be an option for prevention.The purpose of the present study was to examine the in vitro effects of drug delivery systems (DDSs), namely Wax 1 and Wax 2 with different vancomycin content: 0.5, 1, 2 and 4 mg. In order to control the antibacterial activity of DDSs killing curve study was performed and in order to determine the antibiotic release and the antibiotic peak concentration from the DDSs biological assay was carried out.The time kill curve studies showed, that both DDSs with all vancomycin concentration decreased significantly the bacterial counts, however, Wax 2 with 4 mg vancomycin significantly decreased the bacterial count than all the other groups.The vancomycin release was the best with the highest peak concentration from DDSs with 4 mg vancomycin contain; it was significantly better than in the other groups, however, no significant difference was observed between Wax 1 and Wax 2 in this respect.These findings suggest that Wax 2 with 4 mg vancomycin content could be a potential agent for clinical use.
Authors:M. Pappalardo, D. Milardi, D. Grasso, and C. La Rosa
Summary DPPC dispersions containing DPPE with attached PEG of molecular masses 350, 2000 and 5000 were investigated by DSC in order to determine their phase behaviour and potential use as drug delivery systems. In comparison with previously obtained ESR data, DSC provided a definition of the lipid composition and temperature at which the vesicles are in a liquid crystalline phase. For DPPC DPPE-PEG 350 the composition range is at molar fractions 0<&PEG350<0.5.For DPPC DPPE-PEG 2000 the range of applicability is 0<&PEG2000<0.07 and for DPPC/DPPE-PEG 5000 system it is 0<&PEG5000<0.05.
Authors:C. G. Mothé, A. D. Azevedo, W. S. Drumond, S. H. Wang, and R. D. Sinisterra
One of the main purposes of the drugdeliverysystems is to transport the necessary amount of drug to the target site for a pre-established period of time, both efficiently and precisely [ 1 – 3 ]. Thanks to their
Authors:Kamal Dua, Shakti Dhar Shukla, Terezinha de Jesus Andreoli Pinto, and Philip Michael Hansbro
the aging population and increasing prevalence of cigarette smoking globally [ 2 ]. Thus, it is very crucial for an effective drugdeliverysystem to deliver the therapeutic moiety to the target site at the right time and in an appropriate amount
Authors:C. Mothé, A. Azevedo, W. Drumond, and S. Wang
Samples of poly(l,l-lactide)-block-poly(ethylene glycol)-block-poly(l,l-lactide) (PLLA-PEG-PLLA) were synthesized from l,l-lactide polymerization using stannous 2-ethylhexanoate, Sn(Oct)2 as initiator and di-hydroxy-terminated poly(ethylene glycol) (PEG) (Mn = 4000 g mol−1) as co-initiator. The chemical linkage between the PEG segment and the PLA segments was characterized by Fourier transform
infrared spectroscopy (FTIR). Thermogravimetry analysis (TG) revealed the copolymers composition and was capable to show the
deleterious effect of an excess of Sn(Oct)2 in the polymer thermal stability, while Differential Scanning Calorimetry (DSC) allowed the observation of the miscibility
between the PLLA and PEG segments in the different copolymers.