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Introduction To predict the success of an analgesic drug we previously suggested a bibliometric indicator, the Top Journals Selectivity Index (TJSI) (Kissin 2011 ). It represents the ratio (as %) between the number of all

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Simple, rapid and selective NP-TLC and RP-TLC methods are described for analysis of l -arginine, its primary metabolites (l -citrulline, l -glutamine, l -ornithine, asymmetric N G , N G -dimethyl-l -arginine, symmetric N G , N G ′-dimethyl-l -arginine, N G -nitro-l -arginine, N G -hydroxy-l -arginine, N G -monomethyl-l -arginine, agmatine, putrescine, spermidine, spermine, and creatine) and selected drugs (dexamethasone, prednisolone, furosemide, vancomycin, amikacin, fluconazole, digoxin, captopril, dipyrone, metoprolol, and sildenafil), in different therapeutic groups, in model solutions and in spiked human urine. NP-TLC and RP-TLC methods have been used to study the retention of the substances. A variety of mobile phase systems were evaluated for separation of ARG and its metabolites — methanol-50% acetic acid 3:1 ( v/v ) on silica gel and 5% acetic acid-methanol-acetonitrile 50:35:15 ( v/v ) on RP-18 — and for separation of the drugs — acetonitrile-water 2:3 ( v/v ) on silica gel. The effects on selectivity of the polar modifier of mobile phases were also studied.

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The steadily increasing consumption of popular drugs (e.g. common anti-bacterial, anti-convulsant, anti-hallucinatory, anti-inflammatory, and analgesic formulations) prescribed both in human and veterinary medicine (and sometimes available even without medical prescription) results in growing contamination of the environment by these substances and their metabolites. This contamination is naturally directed through the rivers to the seas and oceans and tends to accumulate in these terminal reservoirs.It was the aim of the work discussed in this paper (i) to establish a simple yet efficient solid-phase extraction (SPE) method for isolation of the drugs josamycin, sulfamethoxazole, carbamazepine, diclofenac, and iopromide from aqueous matrices; (ii) to quantify these compounds by use of densitometric TLC; and (iii) to test the method by applying it to environmental samples (river water from South Poland). The results obtained clearly demonstrate that SPE combined with densitometric TLC is highly suited to this analytical task.

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Metal complexes of fenoterol drug

Preparation, spectroscopic, thermal, and biological activity characterization

Journal of Thermal Analysis and Calorimetry
Authors: M. Soliman, Gehad Mohamed, and Eman Mohamed

Introduction Fenoterol (FEN, Fig. 1 ) is β_2-adrenoceptor agonist that may have clinical value in the treatment of congestive heart failure [ 1 , 2 ]. FEN possesses two chiral centers and the drug is supplied as a racemic

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Abstract  

Thermal decomposition of magnesium salts of organic acids used in medicine (Mg acetate, Mg valproate, Mg lactate, Mg citrate, Mg hydrogen aspartate, Zn hydrogen aspartate) was analyzed by thermoanalytical, calorimetrical, and computational methods. Thermoanalytical studies were performed with aid of a derivatograph. 50-, 100-, and 200-mg samples were heated in a static air atmosphere at a heating rate of 3, 5, 10, and 15 °C min−1 up to the final temperature of 700–900 °C. By differential thermal analysis (DTA), thermogravimetry (TG), and derivative thermogravimetry (DTG) methods, it has been established that thermal decomposition of the salts under study occurs via two stages. The first stage (dehydratation) was distinctly marked on the thermoanalytical curves. Calorimetrical studies were carried out by using of a heat-flux Mettler Toledo differential scanning calorimetry (DSC) system. Ten milligram samples of compounds under study were heated in the temperature range from 20 to 400 °C at a heating rate of 10 and 20 °C min−1 under an air stream. The studies showed that the values of transitions heats and enthalpies of dehydration for investigated salts varied with the increasing of heating rate. For chemometric evaluation of thermoanalytical results, the principal component analysis (PCA) was applied. This method revealed that points on PC1 versus PC2 diagrams corresponding to the compounds of similar chemical constitution are localized in the similar ranges of the first two PC’s values. This proves that thermal decomposition reflects similarity in the structure of magnesium salts of organic acids.

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A.A. Hincal 2002 Influence of irradiation sterilization on poly(lactide-co-glycolide) microspheres containing anti-inflammatory drugs II Farmaco 57

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668 678 . 7. C. Lafuente-Lafuente 2006 Antiarrhythmic drugs for maintaining sinus rhythm after cardioversion of

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Elezi, S., Dibra, A., Mehilli, J. és mtsai: Vessel Size and Outcome After Coronary Drug-Eluting Stent Placement. Results From a Large Cohort of Patients Treated With Sirolimus- or Paclitaxel-Eluting Stents. J. Am. Coll. Cardiol., 2006, 48 , 1304

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Orvosi Hetilap
Authors: Katalin Kovács, Anita Réka Tóth, and Éva Margit Kereszty

The life of a drug user. [Szösszenetek egy volt drogos életéből.] http://drogos.freeblog.hu/archives/2011/03/05/Metilon/ [Hungarian] Shimizu, E., Watanabe, H., Kojima, T., et al.: Combined

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