The proportion of Escherichia coli non-susceptible to 3rd generation cephalosprins from invasive clinical samples has risen in Hungary from 5.1 per cent in 2006 to 15.5 per cent in 2011. The prevalence of ESBL-production in E. coli of animal origin remains unknown. During the first stage of a probe forty-five human and 18 animal ESBL-producing E. coli strains isolated in 2006-2007 were investigated. The human strains were representatively selected from a collection of 113 ESBL-producing isolates sent to the national reference center from local laboratories across the country. A variety of ESBLs were detected (SHV-2, -5, -12, CTX-M-32) with CTX-M-15 being the most common in human and CTX-M-1 the dominant in animal isolates. Genetic characterization revealed that thirty-six human isolates (80 per cent) belonged to either the phylogenetic group (PG) B2 or D. Conversely, 15 animal isolates (83 per cent) proved to be members of the A and B1 commensal PGs. Furthermore 46 per cent of human isolates (21/45) from 12 centres belonged to the international O25-ST131/B2 clone while nine isolates from seven centers showed the O15 serotype. Pulsed-field gel electrophoresis (PFGE) detected 22 and 11 diverse pulsotypes among 45 human and 18 animal isolates, respectively. The human and animal strains did not share any pulsotypes.
Authors:Yeliz Çetinkol, Cemal Sandalli, Mustafa Kerem Çalgin, Arzu Altunçekiç Yildirim, Esma Akyildiz, Esin Karaman, and Ayşegül Çopur Çiçek
]. The number of β-lactamase and especially extended-spectrum β-lactamase (ESBL)-producing strains is increasing around the world. The variants and types of ESBL enzymes have occurred due to many reasons, one of them is selective pressure caused by the
Authors:Ahmed Gaballah, Amira Elbaradei, Amel Elsheredy, and Ola Kader
-lactamase (ESBL) and AmpC β-lactamases hyperproduction, whereas those resistant to IPM and/or MEM were further screened for the presence of carbapenemases and MBL.
Screening for ESBL production
Authors:Abimbola Olumide Adekanmbi, Sandra Usidamen, and Anthony Abiodun Onilude
studies during this period have reported about 20–45% resistance to these antibiotics by UPEC isolates [ 9, 10 ] and this is also in addition to the ability of UPEC to produce extended spectrum ß-lactamase (ESBL) [ 11 ]. ESBLs have the ability to
Authors:Fatemeh Eghbalpoor, Mehri Habibi, Omid Azizi, Mohammad Reza Asadi Karam, and Saeid Bouzari
-lactamase enzymes named as extended-spectrum β-lactamases (ESBLs) [ 10 ]. TEM, SHV, and CTX-M as the most common ESBL types confer resistance to all β-lactam antibiotics, except for carbapenems, and β-lactamase inhibitors. Furthermore, ESBL-producing isolates
Authors:Abed Zahedi Bialvaei, Tala Pourlak, Mina Aghamali, Mohammad Asgharzadeh, Pourya Gholizadeh, and Hossein Samadi Kafil
, Bialvaei A , Ghotaslou R , Asgharzadeh M , Naghili B , Pirzadeh T , et al.: Faecal carriage of ESBL and plasmidmediated AmpC ß-lactamase genes in Klebsiella spp. and Shigella spp. isolated from inpatient and outpatient carriers in Tabriz, Iran
Authors:Mehdi Moghadampour, Aliakbar Rezaei, and Jamshid Faghri
resistant strains between the hospital and community has been described previously [ 2 ]. Treatment of infections caused by drug-resistant K. pneumoniae isolates, especially strains producing extended-spectrum beta-lactamases (ESBLs), as well as isolates
Authors:Julia Münch, Ralf Matthias Hagen, Martin Müller, Viktor Kellert, Dorothea Franziska Wiemer, Rebecca Hinz, Norbert Georg Schwarz, and Hagen Frickmann
, Küpper MF , de With K , Serr A , Bohnert JA , Kern WV : Intestinal decolonization of Enterobacteriaceae producing extended-spectrum ß-lactamases (ESBL): a retrospective observational study in patients at risk