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Phillips EM 208S, transmission electron microscope (TEM). Synthesis of Fe 3 O 4 nanoparticles (MNPs) Fe 3 O 4 nanoparticles were prepared according to the previously reported method [ 33 ]. A NaOH solution (4 M, 100 ml) was

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Journal of Radioanalytical and Nuclear Chemistry
Authors: X. Zhang, R. Zhou, W. Rao, Shanghai 201800 P.R. China Shanghai 201800 P.R. China, and Shanghai 201800 P.R. Shanghai 201800 P.R. C

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Shanghai 201800,

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Abstract  

DMSA-coated Fe3O4 nanoparticles were synthesized by wet-chemical method. The chemical interaction between Fe3O4 and DMSA were investigated by FTIR. They were directly radiolabeled with 99mTc radioisotope (Fe3O4@DMSA–99mTc) at room temperature in the presence of stannous solution as a reducing agent. Magnetic and structure properties of Fe3O4@DMSA–99mTc nanoparticles were investigated by AGFM, TEM, and XRD. Biodistribution and toxicity assessment of Fe3O4@DMSA–99mTc were studied in mice by intravenous and intraperitoneally injections, respectively. Blood, kidney, and liver factors were measured 4 days post injection and at the mean-while tissue sections were prepared from their kidney and liver. The results indicate that, the Fe3O4@DMSA–99mTc nanoparticles were passed through the membrane of different cells but do not create any disorder in the kidney and liver function even in high doses such as 300 mg/kg.

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Canada, Ltd., Oakville, Ontario, Canada. Fe 3 O 4 nanoparticles were obtained from Nanostructured and Amorphous Materials, Inc., Houston, TX. n -heptane (HPLC grade, Sigma-Aldrich) and toluene (analytical grade, EMD, MERCK, NJ) were used for asphaltene

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This study examined the applications of novel non-polymer magnetic ferrite nanoparticles (Fe3O4 NPs) labeled with 99mTc-pertechnetate (99mTcO4 ). The radiochemistry, chemistry, and biodistribution of Fe3O4 NPs labeled with 9mTcO4 were analyzed. This paper employed instant thin layer chromatography and magnetic adsorption to evaluate the labeling efficiency and stability of 99mTc-Fe3O4 at various reaction conditions. A scanning electron microscope, X-ray diffractometer, Fourier transform infrared spectrometer, laser particle size analyzer, and superconducting quantum interference device magnetometer were used to analyze the physical and chemical properties of the Fe3O4 and 99Tc-Fe3O4 nanoparticles. The biodistribution and excretion of 99mTc-Fe3O4 were also investigated. Radiochemical analyses showed that the labeling efficiency was over 92% after 1 min in the presence of a reducing agent. Hydroxyl and amine groups covered the surface of the Fe3O4 particles. Therefore, 99Tc (VII) reduced to lower oxidation states and might bind to Fe3O4 NPs. The sizes of the 99Tc-Fe3O4 NPs were about 600 nm without ultrasound vibrations, and the particle sizes were reduced to 250 nm under ultrasound vibration conditions. Nonetheless, Fe3O4 NPs and 99Tc-Fe3O4 NPs exhibited superparamagnetic properties, and the saturation magnetization values were about 55 and 47 emu/g, respectively. The biodistribution showed that a portion of the 99mTc-Fe3O4 nanoparticles might embolize in a pulmonary capillary initially; the embolism radioactivity was cleared from the lungs and was then taken up by the liver. 99mTc-Fe3O4 metabolized very slowly only 1–2% of the injected dose (ID) was excreted in urine and about 2.37% ID/g was retained in the liver 4 h after injection. Radiopharmaceutically, 99mTc-Fe3O4 NPs displayed long-term retention, and only 99mTc-Fe3O4 NPs that dissociated to free pertechnetate could be excreted in urine. This research evaluated the feasibility of non-polymer magnetic ferrite NPs labeled with technetium as potential radiopharmaceuticals in nuclear medicine.

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Journal of Radioanalytical and Nuclear Chemistry
Authors: Debasish Das, M. Sureshkumar, Siddhartha Koley, Nidhi Mithal, and C. Pillai

Abstract  

Magnetite (Fe3O4) nanoparticle was synthesized using a solid state mechanochemical method and used for studying the sorption of uranium(VI) from aqueous solution onto the nanomaterial. The synthesized product is characterized using SEM, XRD and XPS. The particles were found to be largely agglomerated. XPS analysis showed that Fe(II)/Fe(III) ratio of the product is 0.58. Sorption of uranium on the synthesized nanomaterials was studied as a function of various operational parameters such as pH, initial metal ion concentration, ionic strength and contact time. pH studies showed that uranium sorption on magnetite is maximum in neutral solution. Uranium sorption onto magnetite showed two step kinetics, an initial fast sorption completing in 4–6 h followed by a slow uptake extending to several days. XPS analysis of the nanoparticle after sorption of uranium showed presence of the reduced species U(IV) on the nanoparticle surface. Fe(II)/Fe(III) ratio of the nanoparticle after uranium sorption was found to be 0.48, lower than the initial value indicating that some of the ferrous ion might be oxidized in the presence of uranium(VI). Uranium sorption studies were also conducted with effluent from ammonium diuranate precipitation process having a uranium concentration of about 4 ppm. 42% removal was observed during 6 h of equilibration.

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(Zeller) (Lepidoptera: Gelechiidae) . J. Crop Prot. 2 , 93 – 99 . Safaei-Ghomi , J. and Zahedi , S. ( 2015 ): l-Proline-functionalized Fe3O4 nanoparticles as a novel magnetic

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have been synthesized [ 19 ], in which among them, magnetic iron oxide (e.g., maghemite γ-Fe 2 O 3 or magnetite Fe 3 O 4 ) nanoparticles have attracted tremendous attentions due to their low toxicity, stability, and biocompatibility in the

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researches because of their unique and alluring properties [ 12 ], such as excellent mechanical stiffness, nanoscale size, and high specific surface area [ 13 ]. Furthermore, magnetic materials of Fe 3 O 4 nanoparticles (MNPs) as adsorbents have excellent

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, 15 , 3403 – 3409 “ Continuous preparation of Fe3O4 nanoparticles using a rotating packed bed: dependence of size and magnetic property on temperature ” C. Lin , J. Ho , M. Wu , Powder Technology 2015 , 274 , 441 – 445

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