Authors:Jun-ichi Yoshida, Heejin Kim and Aiichiro Nagaki
-lived reactive intermediate is generated in a flow microreactor system, we have been developing reactions that are very difficult or impossible to achieve by conventional flask reactions [ 1 , 2 ]. In 2005, we named this chemistry flashchemistry [ 3 ]. In flash
Authors:Toshiya Yoshiiwa, Satoshi Umezu, Manabu Tokeshi, Yoshinobu Baba and Mitsuru Shindo
We report a method for the generation and subsequent reaction of ynolates in a flow microreactor via a stop-flow process. This procedure allowed for the synthesis of ynolates at ambient temperature within 11 min via a Li–Br exchange reaction with sec-butyllithium, whereas the corresponding batch process generally requires low temperature control and extended reaction times of up to 1 h. The stop-flow method is especially useful for optimizing the reaction time without having to use various microtube lengths. The resulting ynolates were applied to the olefination of carbonyl compounds and to pyrrole synthesis. These results indicate the practical utility of the ynolate reaction and should contribute to progress in flash chemistry.
Authors:Robert Green, Richard Brown and Derek Pletcher
.; Sato M.; Ryu, I. Synlett 2008 , 151â€"163; (d) Yoshida, J. FlashChemistry: Fast Organic Synthesis in Microsystems ; Wiley-VCH: Weinheim, 2008; (e) Chemical Reactions and Processes under Flow Conditions ; Luis S. V.; Garcia-Verdugo, E., Eds.; Royal
Materials 2015 , 5
“ Reactions of difunctional electrophiles with functionalized aryllithium compounds: remarkable chemoselectivity by flashchemistry ” A. Nagaki , K. Imai , S. Ishiuchi , J. Yoshida Angew. Chem. Int. Ed. 2015
Authors:Kimitada Terao, Yasuhiro Nishiyama and Kiyomi Kakiuchi
, J. P. Angew. Chem. Int. Ed. 2011 , 50 , 1000.
For reviews and important reports on microreactors; (a) Yoshida, J. FlashChemistry: Fast Organic Synthesis in Microsystems ; Wiley: Hoboken, 2008; (b) Fukuyama, T.; Rahman
carbide microreactor” S. G. Newman, L. Gu, C. Lesniak, G. Victor, F. Meschke, L. Abahmane, K. F. Jensen* Green Chemistry 2014 , 16 , 176–180
“Three-component coupling based on flashchemistry. Carbolithiation of benzyne with
-flow microreactors (see, for example, flashchemistry [ 9 ] or the so-called forgotten chemistries) [ 1 ], it is only a matter of time before these are picked up in the polymer field. A specific role is here assigned to electrochemistry [ 56 ]. Electrochemistry in