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-lived reactive intermediate is generated in a flow microreactor system, we have been developing reactions that are very difficult or impossible to achieve by conventional flask reactions [ 1 , 2 ]. In 2005, we named this chemistry flash chemistry [ 3 ]. In flash

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Journal of Flow Chemistry
Authors: Toshiya Yoshiiwa, Satoshi Umezu, Manabu Tokeshi, Yoshinobu Baba and Mitsuru Shindo

We report a method for the generation and subsequent reaction of ynolates in a flow microreactor via a stop-flow process. This procedure allowed for the synthesis of ynolates at ambient temperature within 11 min via a Li–Br exchange reaction with sec-butyllithium, whereas the corresponding batch process generally requires low temperature control and extended reaction times of up to 1 h. The stop-flow method is especially useful for optimizing the reaction time without having to use various microtube lengths. The resulting ynolates were applied to the olefination of carbonyl compounds and to pyrrole synthesis. These results indicate the practical utility of the ynolate reaction and should contribute to progress in flash chemistry.

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.; Sato M.; Ryu, I. Synlett 2008 , 151â€"163; (d) Yoshida, J. Flash Chemistry: Fast Organic Synthesis in Microsystems ; Wiley-VCH: Weinheim, 2008; (e) Chemical Reactions and Processes under Flow Conditions ; Luis S. V.; Garcia-Verdugo, E., Eds.; Royal

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Materials 2015 , 5 “ Reactions of difunctional electrophiles with functionalized aryllithium compounds: remarkable chemoselectivity by flash chemistry ” A. Nagaki , K. Imai , S. Ishiuchi , J. Yoshida Angew. Chem. Int. Ed. 2015

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, J. P. Angew. Chem. Int. Ed. 2011 , 50 , 1000. For reviews and important reports on microreactors; (a) Yoshida, J. Flash Chemistry: Fast Organic Synthesis in Microsystems ; Wiley: Hoboken, 2008; (b) Fukuyama, T.; Rahman

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carbide microreactor” S. G. Newman, L. Gu, C. Lesniak, G. Victor, F. Meschke, L. Abahmane, K. F. Jensen* Green Chemistry 2014 , 16 , 176–180 “Three-component coupling based on flash chemistry. Carbolithiation of benzyne with

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Journal of Flow Chemistry
Authors: Leonardo Degennaro, Claudia Carlucci, Sonia De Angelis and Renzo Luisi

. Angew. Chem., Int. Ed. 2015 , 54 , 13501 . 9. Yoshida , J.-i. Flash Chemistry. Fast Organic Synthesis in

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Journal of Flow Chemistry
Authors: Bernhard Gutmann, David Obermayer, Jean-Paul Roduit, Dominique M. Roberge and C. Oliver Kappe

-VCH: Weinheim, 2009; (c) Microreactors in Organic Synthesis and Catalysis ; Wirth, T., Ed.; Wiley: Weinheim, 2008; (d) Yoshida , J.-i. Flash Chemistry: Fast Organic Synthesis in Microsystems ; Wiley: Chichester , 2008

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. ; Wohlgemuth R. ; Szita N. Biotechnol. J. 2017 , 12 , 1700030 . 10.1002/biot.201700030 12. Flash Chemistry: Fast Organic Synthesis in Microsystems Yoshida

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-flow microreactors (see, for example, flash chemistry [ 9 ] or the so-called forgotten chemistries) [ 1 ], it is only a matter of time before these are picked up in the polymer field. A specific role is here assigned to electrochemistry [ 56 ]. Electrochemistry in

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