The use of continuous-flow chemistry has shown to be an important tool in improving API manufacture. In the present paper, we report the use of continuous-flow reactors in the synthesis of the bicyclic side chain of antiretroviral Darunavir.
cells. Antimicrob. Agents Chemother., 2013, 57 (9), 4481–4488. 73 Zastre, J. A., Chan, G. N., Ronaldson, P. T., et al.: Up-regulation of P-glycoprotein by HIV protease
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]. This flow assay was created to measure hydrolysis of an appropriately tagged human immunodeficiency virus (HIV) protease substrate in the presence of different inhibitors. In this flow system, enzyme and inhibitor are introduced into the flow system in
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