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Journal of Flow Chemistry
Authors: Raquel A. C. Leão, Raquel de O. Lopes, Marco A. de M. Bezerra, Mauro N. Muniz, Bruna B. Casanova, Simone C. B. Gnoatto, Grace Gosmann, Laszlo Kocsis, Rodrigo O.M.A. de Souza, and Leandro S. de M. Miranda

The use of continuous-flow chemistry has shown to be an important tool in improving API manufacture. In the present paper, we report the use of continuous-flow reactors in the synthesis of the bicyclic side chain of antiretroviral Darunavir.

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Orvosi Hetilap
Authors: Franciska Erdő, Csilla Temesszentandrási-Ambrus, and Erzsébet Beéry

cells. Antimicrob. Agents Chemother., 2013, 57 (9), 4481–4488. 73 Zastre, J. A., Chan, G. N., Ronaldson, P. T., et al.: Up-regulation of P-glycoprotein by HIV protease

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Letters 2013 , 13 , 3936 – 3941 . “A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir” L. Dalla-Vechia , B. Reichart , T. Glasnov , L. S. M. Miranda , C. O. Kappe ,* R. O. M

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Biologia Futura
Authors: Mughal Qayum, Muhammad Nisar, Abdur Rauf, Imran Khan, Waqar Ahmad Kaleem, Muslim Raza, Nasiara Karim, Munawar Ahmad Saleem, Saud Bawazeer, Sengul Uysal, Gokhan Zengin, Saqib Jahan, and Mohamed Fawzy Ramadan

. , Torbett , B. E. ( 2010 ) Virtual screening for HIV protease inhibitors: a comparison of AutoDock 4 and Vina . PloS One 5 , e11955 . 10.1371/journal.pone.0011955 Don , M

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. Ben-Romano R , Rudich A : Agent and cell-type specificity in the induction of insulin resistance by HIV protease inhibitors . AIDS 17

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]. This flow assay was created to measure hydrolysis of an appropriately tagged human immunodeficiency virus (HIV) protease substrate in the presence of different inhibitors. In this flow system, enzyme and inhibitor are introduced into the flow system in

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.biomaterials.2012.03.046 59. Yu L , Bridgers A , Polli J , Vickers A , Long S , Roy A , Vitamin E-TPGS increases absorption flux of an HIV protease inhibitor by enhancing its solubility and permeability1 . Pharm Res 1999 ; 16 ( 12 ): 1812 – 7

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