Authors:Raquel A. C. Leão, Raquel de O. Lopes, Marco A. de M. Bezerra, Mauro N. Muniz, Bruna B. Casanova, Simone C. B. Gnoatto, Grace Gosmann, Laszlo Kocsis, Rodrigo O.M.A. de Souza, and Leandro S. de M. Miranda
The use of continuous-flow chemistry has shown to be an important tool in improving API manufacture. In the present paper, we report the use of continuous-flow reactors in the synthesis of the bicyclic side chain of antiretroviral Darunavir.
Letters 2013 , 13 , 3936 – 3941 .
“A three step continuous flow synthesis of the biaryl unit of the HIVprotease inhibitor Atazanavir” L. Dalla-Vechia , B. Reichart , T. Glasnov , L. S. M. Miranda , C. O. Kappe ,* R. O. M
Authors:Mughal Qayum, Muhammad Nisar, Abdur Rauf, Imran Khan, Waqar Ahmad Kaleem, Muslim Raza, Nasiara Karim, Munawar Ahmad Saleem, Saud Bawazeer, Sengul Uysal, Gokhan Zengin, Saqib Jahan, and Mohamed Fawzy Ramadan
Torbett , B. E.
( 2010 ) Virtual screening for HIVprotease inhibitors: a comparison of AutoDock 4 and Vina . PloS One 5 , e11955 . 10.1371/journal.pone.0011955
Don , M
]. This flow assay was created to measure hydrolysis of an appropriately tagged human immunodeficiency virus (HIV) protease substrate in the presence of different inhibitors. In this flow system, enzyme and inhibitor are introduced into the flow system in
Authors:Minnja S. Hartmann, Soraya Mousavi, Stefan Bereswill, and Markus M. Heimesaat
.biomaterials.2012.03.046 59. Yu L , Bridgers A , Polli J , Vickers A , Long S , Roy A , Vitamin E-TPGS increases absorption flux of an HIVprotease inhibitor by enhancing its solubility and permeability1 . Pharm Res 1999 ; 16 ( 12 ): 1812 – 7