A new formulation of a freeze-dried kit for the labeling of tetrofosmin with technetium-99m has been developed. The kit contains
lyophilized mixture of 0.320 mg tetrofosmin [6,9-bis(2-ethoxyethyl)-3,12-dioxa-6,9-diphosphatetradecane], 0.025 mg stannous
chloride dihydrate, 5 mg sodium tartrate and 5 mg sodium hydrogen carbonate. The product contains no antimicrobial preservative.
When 99mTc pertechnetate up to 6 mL saline containing 200 mCi is added to lyophilized mixture, a lipophilic, cationic 99mTc complex is formed, 99mTc-tetrofosmin. The performance of newly developed kit is compared with commercially available MYOVIEW kit for heart imaging.
The patient studies show that the images of heart obtained by 99mTc-tetrofosmin prepared by new formulation are equally good to MYOVIEW.
Fatty acid are the major energy source for the myocardium, thus radiolabeled fatty have often employed as heart imaging agent to localize ischemia and as potential probes of myocardial metabolism. This paper presents the synthesis of phenyl-pentadecanoic acid (PPA) by alkylation reaction and Wollf-Kishner method. Finally, PPA was iodinated with thallium trifluoroacetate on localizing para-position of phenyl ring and radioiodine was exchanged. The overall chemical yield was 20%, labelling yield 95%, radiochemical purity 98%. Tissues distribution of mice shows that IPPA was very high activity in mice heart muscle. Autoradiogram of mouse section at 2 min is clear.
The radiopharmaceutical201TlCl(thallium-201 chloride) is used in nuclear medicine for myocardial visualization. The solution of201TlCl was prepared using201Tl obtained by irradiating a natural mercury target with protons from the CV-28 cyclotron installed at IPEN-CNEN/SP. This solution was subjected to different quality control processes required for its use in medicine. Some of these controls concerned the determination of the radionuclidic impurities:200Tl,202Tl and203Hg; the chemical identification of201Tl+; the hydrazine concentration, mercury contamination and the presence of phosphate. Furthermore. the biological distribution in Wistar rats and tests for sterility, pyrogenicity and toxicity were carried out. It was verified that the solution obtained was in the form of thallous chloride. This radiopharmaceutical gave good heart images in animals but due to the high levels of200Tl and202Tl its use in humans is not possible unless enriched202Hg is used as target in the irradiation.
Conventional qualitative assessment of CTA images (A) enables stenosis localization, stenosis grading and establishing calcium scoring. Cross-sectional image of the 3D CTA heartimage (B); stretched multiplanar-reformatted image of the selected artery (C