Authors:Ádám Bálint, István Kiss, Krisztián Bányai, Imre Biksi, Katalin Szentpáli-Gavallér, Tibor Magyar, István Jankovics, Mónika Rózsa, Bálint Szalai, Mária Takács, Ádám Tóth and Ádám Dán
In 2010, two novel porcine H1N1 influenza viruses were isolated from pigs with influenza-like illness in Hungarian swine herds. Sequence and phylogenetic analysis of these strains revealed that they shared molecular features with the pandemic H1N1 influenza virus strains, which emerged globally during 2009. The PB2, HA and NA genes contained unique amino acid changes compared to the available new H1N1 influenza virus sequences of pig origin. Furthermore, the investigated strains could be separated with respect to parallel amino acid substitutions affecting the polymerase genes (PB2, PB1 and PA) and the nucleoprotein (NP) gene, supporting the proposed complementarities between these proteins, all required for the viral fitness. Molecular characterisation of two Hungarian human pandemic H1N1 isolates was also performed, so that we could compare contemporaneous strains of different host species origins. Shared molecular motifs in various genes of animal and human influenza strains suggested that the Hungarian porcine strains could have originated from humans through direct interspecies transmission. This study is among the few that support the natural human-to-pig transmission of the pandemic H1N1 influenza virus.
Until recently the etiology of bovine spongiform encephalopathy (BSE) was considered uniform. The infectious agent was thought to be a single strain of prion (posttranslationally altered form of normal prion protein: PrPSc) retaining its biochemical and biological characteristics during interspecies transmission. However, alternate PrPSc signatures through large-scale screening have recently been detected. In addition, genetic alterations governing susceptibility to prion infection and a mutation (E211K) capable of eliciting spontaneous BSE have been demonstrated. Thus, the spectrum of BSEs have broadened and three PrPSc variants (BSE-C, BSE-H and BSE-L) are now defined. Moreover, a new condition resembling BSE, idiopathic brainstem neuronal chromatolysis (IBNC), has been described that may also turn out to be a prion disease. Since one of the new BSE variants, L-type BSE, proved highly pathogenic detection and further characterization of the new conditions are essential.
Authors:Krisztián Bányai, Jelle Matthijnssens, György Szücs, Petra Forgách, Károly Erdélyi, Marc van Ranst, Eleonora Lorusso, Nicola Decaro, Gabriella Elia and Vito Martella
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): Full genomic analysis of human rotavirus strain B4106 and lapine rotavirus strain 30/96 provides evidence for interspeciestransmission. J. Virol.
Jiang , S. J. and Xie , Z. J. ( 2014 ): Interspeciestransmission of canine influenza virus H5N2 to cats and chickens by close contact with experimentally infected dogs. Vet. Microbiol. 170 , 414 – 417
Authors:Iva I. Podgorski, Laura Pantó, Katalin Földes, Iris de Winter, Máté Jánoska, Endre Sós, Baptiste Chenet, Balázs Harrach and Mária Benkő
, C. , Vidovszky , M. Z. , Mühldorfer , K. , Dabrowski , P. W. , Radonić , A. , Nitsche , A. , Wibbelt , G. , Kurth , A. and Harrach , B. ( 2012 ): Genome analysis of bat adenovirus 2: indications of interspeciestransmission . J
Authors:Márton Z. Vidovszky, Claudia Kohl, Sándor Boldogh, Tamás Görföl, Gudrun Wibbelt, Andreas Kurth and Balázs Harrach
Kohl , C. , Vidovszky , M. Z. , Mü hldorfer , K. , Dabrowski , P. W. , Radonic , A. , Nitsche , A. , Wibbelt , G. , Kurth , A. and Harrach , B. ( 2012 ): Genome analysis of bat adenovirus 2: indications of interspeciestransmission