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shortening of drug-susceptible and XDR-TB [ 16 ]. In the current work, we conducted studies to characterize the potential for a pharmacokinetic interaction between pretomanid and pyrazinamide in rats using LC-MS/MS. We have developed and validated an LC-MS/MS

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using ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS). In the present study, we established a simple, sensitive, and rapid liquid chromatography (LC)–MS/MS method and validated for determination of PH in dog plasma

Open access
Acta Chromatographica
Authors:
Jelena Dzudovic
,
Milkica Crevar Sakac
,
Marko Antunovic
,
Aleksandra Repic
,
Slobodan Obradovic
,
Snezana Djordjevic
,
Jelena Savic
, and
Boris Dzudovic

[ 10 ]. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is one of the most sensitive analytical methods for the detection, identification and quantification of analyzed compounds on biological samples. Literature survey reveals that

Open access
Acta Chromatographica
Authors:
Tiantian Lu
,
Xiaohong Wang
,
Qi Zhang
,
Kun Liu
,
Tongxin Xu
,
Quande Wang
,
Pengfei Zhao
, and
Zhongzhe Cheng

chromatography-tandem mass spectrometry (LC-MS/MS) method were developed, respectively [ 9 , 11 ]. However, there is little bioanalytical method for the determinatin of solasodine in urinary and fecal samples. In addition, bioanalysis of urine is commonly

Open access
Acta Chromatographica
Authors:
Hao-ran Dai
,
Ya-hui Hu
,
Jia-yi Long
,
Ying Xia
,
Hong-li Guo
,
Jing Xu
,
Xuan-sheng Ding
,
Jing Chen
,
Xiao-peng Lu
, and
Feng Chen

Method Internal standard Matrix Matrix volume (μL) Sample preparation Elution Column Mobile phase Linearity range (ng mL −1 ) Analytical time (min) Reference 2015 LC-MS/MS ER-167615 Plasma 100 LLE by MTBE Isocratic YMC-Pack Pro C8 column (50 × 3.0 mm) 0

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determination of PG can be found in the literature. Liquid chromatography coupled with a tandem mass spectrometer (LC-MS/MS) is preferable method due to its selectivity, accuracy, precision, and robustness [ 13–15 ]. Some of the published methods require a

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ng/mL and an elimination half-life of about 8 h [ 4 ]. Literature survey revealed that LCZ has been reported to be determined by ultraviolet (UV) spectrophotometry [ 3 , 5 ], liquid chromatography–tandem mass spectrometry (LC–MS/MS) in human plasma

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LC–MS/MS method for simultaneous monitoring of RIV and SIT and applied it to the pharmacokinetic study in rats to evaluate DDI interaction between the two drugs in rats. Experimental Chemicals and

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green analytical method to improve the test method of cordycepin and isocordycepin in C. sinensis and other Cordyceps samples. Liquid chromatography tandem mass (LC-MS/MS), which can provide high selectivity and short analysis time, has been employed

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% of the original drug are excreted through the kidney [ 7 ]. HPLC-UV [ 8 , 9 ], HPLC-FL [ 10 ], Micellar electrokinetic chromatography [ 11 , 12 ] and LC-MS/MS [ 13–16 ] method has been developed for determination of letrozole in plasma

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