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of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006; 9: 425–434. 4 Romero-Garcia S, Moreno

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Abstract  

The synergistic effects of zinc oxide (ZnO) with layered double hydroxides (LDH) in ethylene vinyl acetate copolymer/LDH (EVA/LDH) composites have been studied using thermal analysis (TG), limiting oxygen index (LOI), UL-94 tests, and cone calorimeter test (CCT). The results from the UL-94 tests show that the ZnO can also act as flame retardant synergistic agents in the EVA/LDH composites. The CCT data indicated that the addition of ZnO in EVA/LDH system can greatly reduce the heat release rate. The TG data show that the ZnO can increase the thermal degradation temperature and the charred residues after burning.

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β-Agonists have skeletal muscle specific protein anabolic effects and are also known to cause cardiac hypertrophy. Changed total LDH and its isozymic patterns are conveniently employed for the detection of different pathophysiological states of the tissues. The purpose of this study is to confirm total LDH and its isozymic expression in ventricular tissue and serum in mice following oral administration of single but higher dose of isoproterenol (Iso) and clenbuterol (Cl) (100 mg/kg body wt. and 20 mg/kg body wt., respectively), after 4, 8 and 20 hours of drug administration. Mice heart witnessed increased total LDH levels with time. Serum on the other hand showed decline in total LDH concentrations at the initial points of the drug treatment. No doubt, total LDH expression increased towards 20th h post-drug treatment but this increase is mainly due to anaerobic isozymes, i.e. LDH 4 and LDH 5 . The findings of the present study suggest that tissue damage is definitely caused by two β-agonists after giving single dose for shorter time span (20 hours) and the impact of the damage varies from drug to drug. Increase in total LDH in serum is not due to release from heart but from some other tissues having anaerobic metabolism.

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Acta Physiologica Hungarica
Authors:
J Dudka
,
F Burda
,
Barbara Madej
,
Justyna Szumilo
,
Edyta Tokarska
,
Agnieszka Korobowicz
,
R Klepacz
,
Monika ChyüyÅska
, and
Elżbieta Korobowicz

Metabolic acidosis complicates methanol, ethylene glycol and other alcohol intoxications. It is caused firstly by acid metabolites and secondly by the lactate elevation. The aim of the study was to evaluate the effect of alcohol dehydrogenase (ADH; EC 1.1.1.1) inhibitors and substrates: 4-methylpyrazole (4-MP), cimetidine, EDTA, ethanol and methanol on lactate dehydrogenase (LDH; EC 1.1.1.27) activity. The activity of LDH was determined spectrophotometrically in in vitro human heart homogenates with the mentioned compounds at 0.01, 0.1, 1.0 mM concentrations of 4-MP, cimetidine, EDTA, and 12.5, 25.0, 50.0 mM of ethanol and methanol. The LDH activity was significantly inhibited by 0.1 mM (p<0.05) and 1.0 mM (p<0.01) 4-MP and 1.00 mM EDTA (p<0.05). Higher LDH activity vs. control was observed in the samples incubated with all studied ethanol and methanol concentrations but these differences were not statistically significant. Thus, 4-MP was found to be the most effective inhibitor of LDH of all compounds tested. Therefore, such effect of 4-MP seems to be an additional advantage in methanol and ethylene glycol intoxications.

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Introduction Layered double hydroxides (LDHs) are layered compounds composed of positively charged metal hydroxide sheets with intercalated anions and water molecules in the interlayer region. They are also known as

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Journal of Thermal Analysis and Calorimetry
Authors:
Tomohito Kameda
,
Yuki Fubasami
, and
Toshiaki Yoshioka

Introduction Mg–Al layered double hydroxide (Mg–Al LDH) is represented by the formula [Mg 1− x 2+ Al x 3+ (OH) 2 ](A n − ) x / n · m H 2 O, where A n − is an anion, such as CO 3 2− or SO 4 2− , and x is the Al/(Mg + Al

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Introduction Layered double hydroxides (LDHs) and their thermally derived mixed oxides are being extensively investigated due their wide application as catalysts or catalyst supports in organic/pharmaceutical synthesis, clean

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Introduction Layered double hydroxides (LDHs), also called as hydrotalcites or hydrotalcite-like compounds, have received increasing attention in recent years, because of their wide applications as anion exchangers, adsorbents

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the metal or interlayer ions but also on the synthesis conditions and M II /M III molar ratios [ 1 ]. Therefore, these materials are best fitted to the term “tailored materials.” Every LDH hides a secret in its nanogalleries. In recent years

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Introduction Layered double hydroxides (LHDs) are also known as hydrotalcite like materials or anionic clays. Many LDHs such as hydrotalcite, takovite, carrboydite, reevesite, honessite, pyroaurite, and iowaite occur in nature

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