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attractive materials for wide industrial applications. They are used as paints, coatings, matrices, packing materials, outdoor applications, etc. [ 11 – 14 ]. In this article, the establishment of the thermal, viscoelastic, and mechanical properties

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activated by a similar dissolution and geo-polymerization process when contacted with the mixture of alkalis and sulfates. With such a possibility, a composite activator was added into steel slag blended cements, the mechanical properties, durability and

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Solid-state mechanical properties of crystalline drugs and excipients

New data substantiate discovered dielectric viscoelastic characteristics

Journal of Thermal Analysis and Calorimetry
Authors: Shravan Singh Thakur, Manik Pavan Kumar Maheswaram, Dhruthiman Reddy Mantheni, Lakshmi Kaza, Indika Perara, David W. Ball, John Moran, and Alan T. Riga

Abstract

Thermal mechanical analysis (TMA) of crystalline drugs and excipients in their pre-melt temperature range performed in this study corroborate their newly found linear dielectric conductivity properties with temperature. TMA of crystalline active pharmacy ingredients (APIs) or excipients shows softening at 30–100 °C below the calorimetric melting phase transition, which is also observed by dielectric analysis (DEA). Acetophenetidin melts at 135 °C as measured calorimetrically by DSC, but softens under a low mechanical stress at 95 °C. At this pre-melting temperature, the crystals collapse under the applied load, and the TMA probe shows rapid displacement. The mechanical properties yield a softening structure and cause a dimensionally slow disintegration resulting in a sharp dimensional change at the melting point. In order to incorporate these findings into a structure–property relationship, several United States Pharmacopeia (USP) melting-point standard drugs were evaluated by TMA, DSC, and DEA, and compared to the USP standard melt temperatures. The USP standard melt temperature for vanillin (80 °C) [], acetophenetidin (135 °C) [], and caffeine (235 °C) [] are easily verified calorimetrically via DSC. The combined thermal analysis techniques allow for a wide variety of the newly discovered physical properties of drugs and excipients.

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Pollack Periodica
Authors: Fahad Mohanad Kadhim, Muhammad Safa Al-Din Tahir, and Athmar Thamer Naiyf

. This problem leads to a change in mechanical properties, especially in applications that are subjected to dynamic loads, as it directly affects fatigue properties. K. Yang et al. [ 3 ], study on the influence of change resin content on mechanical

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. B. Vásárhelyi M. Gálos 2004 How the water saturation influence the mechanical properties of the volcanic tuffs. Periodica Polytechnica

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Introduction During the last decade, attempts have done to improve the properties of the organic coatings. Corrosion resistance, mechanical properties, appearance, and resistance against ultraviolet (UV) have been the most

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–347. [11] Murashkin M. Yu. , Bobruk E. V. , Kil’mametov A. R. , Valiev R. Z. Structure and mechanical properties of aluminum alloy 6061 subjected to equal

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References Altuntas , E. , Yildiz , M. ( 2007 ) Effect of moisture content on some physical and mechanical properties of faba bean (Vicia faba L.) grains . Journal of

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. 6. Cicek , E. ( 2016 ) Effect of X-ray irradiation on articular cartilage mechanical properties . Acta Phys. Pol. A 129 , 200 – 202 . 7

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improve the strength and durability of subbase material. This paper presents a lab investigation to study the effect of adding PSA on the mechanical properties of granular materials, which conventional used as a subbase course used in roads, highways

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