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Journal of Radioanalytical and Nuclear Chemistry
Authors: Pritty Rao, G. Reddy, S. Vikram Kumar, J. Ramana, N. Chattopadhyay, A. Basu, Seema Srivastava, R. Sarin, V. Raju, and Sanjiv Kumar

Abstract  

The paper describes the simultaneous determination of 14N and 15N isotopes in opium by proton induced γ-ray emission (PIGE) technique. The isotopic ratio of 14N and 15N is a useful parameter for assigning provenance of (seized) illicit drugs. The measurement, non-destructive in nature, is performed on pellets made up of opium powders and is based on the prompt detection of 2.313 and 4.4 MeV γ-rays emanating from 14N(p,p′γ)14N and 15N(p,αγ)12C nuclear reactions respectively, induced simultaneously by 3.6–3.8 MeV proton beam. Positive as well as negative deviations from the natural isotopic abundance (99.63:0.37) were observed in the samples. The precision of the measurements is about 4%. The methodology provides an easy and rapid approach to determine the isotopic ratio of 14N and 15N and has been used for the first time in the analysis of opium.

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Heredity 1972 29 237 245 Singh, S. P., Shukla, S. (2001): Stability parameters for opium and

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, S.K. Mattoo , Am. J. Addict. 20 ( 2010 ) 174 – 175 . [5] B. Hodgson , Opium: A Portrait of the Heavenly Demon , Greystone

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fungal pathogens of opium poppy: the heterothallic Crivellia papaveracea with Brachycladium penicillatum asexual state and a homothallic species with Brachycladium papaveris asexual state . Can. J. Botany 84 , 1304 – 1326 . Meffert , M. E

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In the present paper we establish two new integral inequalities similar to Opial's inequality in two independent variables. The inequalities established in this paper are similar to the analogues of Calvert's generalizations of Opial's inequality, in two independent variables and contains in the special case the analogue of Opial's inequality given by G. S. Yang in two independent variables.

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Abstract  

Rare earth concentrations in 65 Opium, Cannabis and Cannabis resin samples seized from various parts of world were determined by destructive NAA. Great variations in absolute element concentrations, but only small significant differences of rare earth concentration ratios were found, indicating inconsiderable biogeochemical fractionation. The mean values of these ratios correspond with the relative abundances of the rare earths in the upper continental earth's crust.

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( 2009 ) 5. Dang TT , Facchini PJ : Characterization of three O-methyltransferases involved in noscapine biosynthesis in opium poppy . Plant Physiol. 159 , 618 – 631 ( 2012 ) 6. Deng W , Wang H , Rosenberg PA , Volpe JJ , Jensen

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Journal of Radioanalytical and Nuclear Chemistry
Authors: H. Enginar, P. Ünak, F. Lambrecht, F. Biber Müftüler, E. Medine, S. Yolcular, A. Yurt, B. Seyitoğlu, and I. Bulduk

Abstract  

Codeine which was extracted from dry capsules of the opium poppy (Papaver somniferum) was purified by HPLC (High Performance Liquid Chromatography) and characterized by NMR (Nuclear Magnetic Resonance) and IR (Infrared) spectroscopy techniques. The purified compound was labeled with 131I and biodistribution studies were performed in rats. Radioiodinated codeine distributed uniformly in the cerebellum, m.pons, striatum and hypothalamus while the other branch of brain and Stomach, urinary bladder, and small intestine uptakes were significantly higher than other tissues.

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Acta Physiologica Hungarica
Authors: M Mahmoudian, Zahra Siadatpour, SA Ziai, M Mehrpour, Faouzya Benaissa, and M Nobakht

Cytotoxic free radicals and release of several neurotransmitters such as bradykinin contribute to the pathogenesis of hypoxic-ischemic brain damage. We have studied the efficacy of noscapine, an opium alkaloid and a bradykinin antagonist, in reducing post-hypoxic-ischemic damage in developing brain of 7-d-old rat pups. Hypoxic-ischemic injury to the right cerebral hemisphere was produced by legation of the right common carotid artery followed by 3 h of hypoxia with 8% oxygen. Thirty to 45 min before hypoxia the rat pups received noscapine (dose = 0.5-2 mg/kg) or saline. Pups were scarified at 24 h post recovery for the assessment of cerebral damage by histological methods. Our results showed that noscapine was an effective agent in reducing the extent of brain injury after hypoxic-ischemic insult to neonatal rats. Therefore, it is concluded that noscapine may be a useful drug in the managements of patients after stroke.

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