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, et al. Improved anti-tumor response rate with decreased cardiotoxicity on non-pegylated liposomal doxorubicin compared with conventional doxorubicin in first-line treatment of metastatic breast cancer in patients who had received prior adjuvant

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Abstract  

This work reports the synthesis, radiolabeling and preliminary biodistribution results in tumor-bearing mice of [99mTc(CO)3(IDA–PEG3–CB)]. The novel chlorambucil derivative was successfully synthesized by conjugation of iminodiacetic acid (IDA) to chlorambucil via a pegylated linker. The ligand could be labeled by [99mTc(CO)3]+ core in high yield to get [99mTc(CO)3(IDA–PEG3–CB)], which was very hydrophilic and was stable at room temperature. Biodistribution studies in tumor-bearing mice showed that [99mTc(CO)3(IDA–PEG3–CB)] accumulated in the tumor with favorable uptake and retention. The good accumulation in tumor tissue with high tumor/muscle ratios warrants further research to improve tumor targeting efficacy and pharmacokinetic profile of radiolabeled chlorambucil derivative by structural modification.

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, S., Maida, I., és mtsai: Incidence of neutropenia and infections during combination treatment of chronic hepatitis C with pegylated interferon alfa-2a or alfa-2b plus ribavirin. Infection, 2008, 36 , 250

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cardiotoxicity on non-pegylated liposomal doxorubicin compared with conventional doxorubicin in first-line treatment of metastatic breast cancer in patients who had received prior adjuvant doxorubicin: results of a retrospective analysis Anticancer Drugs 17 587

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Tornai, I., Dalmi, L., Gervain, J. et al.: Treatment of patients with chronic hepatitis C using pegylated interferon alfa-2a and ribavirin. The first experiences in Hungary based upon a multicentric, open, prospective study. (In Hungarian). LAM, 2005

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C, using pegylated interferon alfa-2a and ribavirin – the first experiences in Hungary based upon a multicentric, open, prospective study (in Hungarian). LAM, 2005, 15 , 807–813. Gervain J

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2003 38 34 41 Heydtmann, M., Freshwater, D., Dudley, T. et al.: Pegylated interferon alpha-2b for

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–336. 18 Manns, M., Marcellin, P., Poordad, F., et al.: Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naïve patients with chronic hepatitis C virus genotype 1

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2009 Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C Nat Genet 41 1105 1109

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9 2344 2348 Martin, P., Mitra, S., Farrington, K. és mtsai: Pegylated 40 kDa interferon alfa-2a Pegasys is unaffected by renal

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