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deprotonated peptide nitrogen of the metal peptide complexes ( Fig. 2 ). The outside protonation pathway [ 7 , 8 ] is a rapid protonation of the peptide oxygen as a pre-equilibrium, followed by the rate determining breaking of the metal–N(peptide) bond

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-809. Science 283 806 809 MARGULIES, D. H., Interactions of TCRs with MHC-peptide complexes: A quantitative basis

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Abstract  

In vivo imaging of tumours using radiolabelled somatostatin (SST) analogues has become an accepted clinical tool in oncology. HYNIC-Tyr3 octreotide and Tyr3 octreotide were synthesized by FMOC solid-phase peptide synthesis using a semi-automated synthesizer. These were analyzed and purified by RP-HPLC, mass spectroscopy, IR spectroscopy, 1H NMR and 13C NMR. The prochelator 6-BOC-HYNIC was also synthesised and characterised indigenously. HYNIC-Tyr3 octreotide was labelled with 99mTc using Tricine and EDDA as coligand by SnCl2 method. Labelling with 99mTc was performed at 100 °C for 15 min and radiochemical analysis by ITLC and HPLC methods. The radiochemical purity of the complex was over 98% and log p value was found to be −1.27 ± 0.12. The stability of radiolabelled peptide complex was checked at 37 °C up to 24 h. Blood clearance and protein-binding study was also performed. In vivo biodistribution studies in rat showed uptake of 99mTc-HYNIC-TOC in kidney than any other organs. The blood clearance was faster with rapid excretion through kidneys and relatively low uptake in liver.

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Agrokémia és Talajtan
Authors: Gabriella Máthéné Gáspár, Lajos Szabó, Attila Anton, Péter Máthé, and Balázs Orgoványi

1149 Reese, R. N., White, C. A. & Winge, D. R., 1992. Cadmium-sulfide crystallite in Cd-(γEC) n G peptide complexes from tomato. Plant Physiol. 98 . 225

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földtani közeg minőségi védelméhez szükséges határértékekről. Magyar Közlöny. 2000/53. 3157--3158. Reese, R. N., White, C. A. & Winge, D. R., 1992. Cadmium-sulfide crystallite in Cd-(γEC) n G peptide complexes from

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