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A new, simple, and accurate TLC method, using normal- and reversed-phase techniques and densitometric detection, has been developed for measurement of quinapril and hydrochlorothiazide in combination tablets. UV detection at λ = 210 nm was used to quantify the analytes. The drugs were chromatographed on silica gel 60 F 254 HPTLC plates and on octadecilsilane (RP-18) TLC plates, in horizontal chambers, with ethyl acetate-acetone-acetic acid, 8 + 2 + 0.5 ( v/v ) and methanol-0.07 m phosphate buffer, pH 2.5, 6 + 4 ( v/v ), respectively, as mobile phases. The active substances were extracted from tablets with methanol (96% < mean recovery < 104%). Calibration curves were constructed in the range 0.4 to 2.4 μg μL −1 for quinapril and 0.25 to 1.5 μg μL −1 for hydrochlorothiazide, with good correlation ( r ≥ 0.998). The precision ( RSD < 4.4%) and accuracy (2.91 < RE < 3.92) were satisfactory for TLC-densitometric determination of quinapril in combination with hydrochlorothiazide in commercial tablets.

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A rapid and simple method has been developed for chromatographic separation of the pharmacologically active components of some antihypertensive drugs. The active compounds — lisinopril, cilazapril, captopril, quinapril, and ramipril — were successfully separated on aminoplast layers with benzene-cyclohexane-methyl ethyl ketone, 15 + 10 + 15 ( v/v ), as mobile phase. The mechanism of retention and the correlation between lipophilicity and log P were both investigated.

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Acta Physiologica Hungarica
Authors: M. Matrai, B. Szekacs, M. Mericli, G. Nadasy, M. Szekeres, F. Banhidy, G. Bekesi, E. Monos and Szabolcs Várbíró

perindopril, quinapril, hydralazine or amlodipine. J. Hypertens. 4, 389–397 (1996) Thurston H. Endothelium-dependent relaxation in resistance arteries from spontaneously hypertensive rats

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1991 Quinapril 7 1991 Perindopril 8 1993

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) demonstrated that the activity of circulatory RAS blunts the hypotensive effects of ISO-induced heart failure and treatment with ACEi (quinapril) and ARBs (losartan) did not prevent the ISO-induced cardiac hypertrophy as well as ARBs enhanced the increase in

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