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. He , C. , Holmes , J. , Anthony , J. 2014 . SNP genotyping: the KASP assay . Methods Mol. Biol. 1145 : 75 – 86 . Huang , X.Q. , Hsam , S.L.K. , Zeller , F

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Acta Veterinaria Hungarica
Authors: Eszter Erika Balogh, György Gábor, Szilárd Bodó, László Rózsa, József Rátky, Attila Zsolnai, and István Anton

. , Jiang , S. W. , Deng , C. Y. , Xiong , Y. Z. and Li , F. E. ( 2011 ): A SNP in the miR-27a gene is associated with litter size in pigs . Mol. Biol. Rep. 38 , 3725 – 3729

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, A. , Lundström , K. , Marklund , S. and Näsholm , A. ( 2012 ): Associations between candidate SNPs in the calpain 1, calpastatin and leptin genes and meat tenderness among Swedish beef populations . Acta Agric. Scand., Section A – Anim. Sci

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During the last century wheat landraces were replaced by modern wheat cultivars leading to a gradual process of genetic erosion. Landraces genotyping and phenotyping are strategically useful, as they could broaden the genetic base of modern cultivars. In this research, we explored Single Nucleotide Polymorphism (SNP) markers diversity in a collection of common and durum wheats, including both landraces and Italian elite cultivars. A panel of 6,872 SNP markers was used to analyze the genetic variability among the accessions, using both the Principal Components Analysis (PCA) and the Neighbour Joining clustering method. PCA analysis separated common wheat accessions from durum ones, and allowed to group separately durum landraces from durum elite cultivars. The Neighbour joining clustering validated PCA results, and moreover, separated common wheat landraces from common elite cultivars. The clustering results demonstrated that Italian durum landraces were poorly exploited in modern breeding programs. Combining cluster results with heterozygosity levels observed, it was possible to clarify synonymy and homonymy cases identified for Bianchetta, Risciola, Saragolla, Timilia and Dauno III accessions. The SNP panel was also used to detect the minimum number of markers to discriminate the studied accessions. A set of 33 SNPs were found to be highly informative and used for a molecular barcode, which could be useful for cultivar identification and for the traceability of wheat end-products.

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Physiology International
Authors: Gholamreza Rezamand, Touraj Mahmoudi, Seidamir Pasha Tabaeian, Hamid Farahani, Fatemeh Shahinmehr, Hossein Nobakht, Reza Dabiri, Asadollah Asadi, Fariborz Mansour-Ghanaei, and Mohammad Reza Zali

]. A positive association has also been found between NAFLD and serum insulin levels [ 7 ]. Lastly, NAFLD has been associated with single nucleotide polymorphisms (SNPs) in insulin pathway-related genes [ 8–10 ]. There is growing evidence

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Physiology International
Authors: Gholamreza Rezamand, Touraj Mahmoudi, Seidamir Pasha Tabaeian, Hamid Farahani, Fatemeh Shahinmehr, Hossein Nobakht, Reza Dabiri, Asadollah Asadi, Fariborz Mansour-Ghanaei, and Mohammad Reza Zali

]. A positive association has also been found between NAFLD and serum insulin levels [ 7 ]. Lastly, NAFLD has been associated with single nucleotide polymorphisms (SNPs) in insulin pathway-related genes [ 8–10 ]. There is growing evidence

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Chakravarti, A. 1998. It’s raining SNPs, hallelujah? Nat. Genet. 19 :216–217. Chakravarti A. It’s raining SNPs, hallelujah? Nat. Genet

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Acta Veterinaria Hungarica
Authors: Dorottya Földi, Zsuzsa Kreizinger, Katinka Bekő, Nikolett Belecz, Krisztián Bányai, Krisztián Kiss, Imre Biksi, and Miklós Gyuranecz

isolates have been investigated for resistance-related point mutations (SNPs) in the 23S rRNA gene and the L4, L22 protein genes of the 50S ribosome by Kobayashi et al. (2005) . A point mutation A2059G (according to Escherichia coli numbering) at the V

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Tomlinson I, Webb E, Carvajal-Carmona L, et al. A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet. 2007; 39: 984

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Az autoimmun megbetegedések komplex genetikai hajlamának kialakításában számos betegségre érzékenyítő gén játszik szerepet, amelyek bizonyos környezeti tényezőkkel együtthatásban autoimmun tünetek megjelenését eredményezik. Napjaink vizsgálatai révén mind teljesebb kép bontakozik ki az autoimmun betegségek patomechanizmusát illetően. Ehhez jelentős mértékben hozzájárulnak az autoimmun betegséghajlam kialakításáért felelős „kulcsgének” mutációi által előidézett ritka monogénes autoimmun kórképek és az állatkísérletes modellek tanulságai, továbbá a genetikai polimorfizmusokra és az egyidejűleg sok ezer gén és intergenikus DNS-elem kifejeződésére vonatkozó vizsgálatok eredményei. Az autoimmun megbetegedésekkel kapcsolatos problémakör számos kérdése mindmáig válaszra vár. Korunk genomikai kutatásai a jövőben esélyt teremthetnek a preventív medicina bevezetésére az autoimmun megbetegedések esetében.

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