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OTPhOR ∗, AM 3 OCO(TPh)OR ∗, and PAM 3 OCO(TPh)OR ∗ Experimental Materials The n -butyllithium ( n -BuLi) (2.72 M in hexane, packaged under Argon in resealable), trimethyl

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Acta Microbiologica et Immunologica Hungarica
Authors: Aleksandra Šmitran, Dragana Vuković, Nataša Opavski, Ina Gajić, Jelena Marinković, Ljiljana Božić, Irena Živanović, Dušan Kekić, Sunčica Popović, and Lazar Ranin

(TPh), to life-threatening, such as necrotizing fasciitis and sepsis [ 1 ]. In addition, GAS is asymptomatically carried in the throats of healthy persons. A recently conducted meta-analysis estimated the pooled prevalence of GAS carriage among children

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]. MSZ 21470-50:2006: Analysis of the microelement content of soils. (in Hungarian) . [18]. MSZ 21470-94:2001, MSZ 21470-84:2002: TPH and PAH analysis (in Hungarian

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Abstract  

Triprolidine hydrochloride, C19H22N2HClH2O (TPH) is a well-known antihistamine drug, which is reported as being photosensitive. Solid-state photostability studies of TPH were undertaken by irradiating TPH and its binary mixtures with β-cyclodextrin (BCD) and glucose, using an Atlas Suntest CPS+ irradiation chamber and conditions according to the guidelines of the International Committee on Harmonization (ICH). HPLC analysis was used to determine the extent of photodegradation. XRD results showed that changes in the TPH crystal structure had occurred during irradiation and that these changes increased with the time of irradiation. Although the potential for isomerization under the influence of UV-light to the pharmaceutically inactive Z-isomer exists, results have proved that this transformation for solid-state TPH would require more extreme light conditions. The results of this study thus illustrate the general light stability of TPH in the solid-state.

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Abstract  

Triprolidine hydrochloride (C19H22N2·HCl·H2O) (TPH) is a well-known antihistamine drug which is reported as being photosensitive. The thermal stabilities of TPH and of 1:1 molar and 1:1 mass ratio physical mixtures of TPH with β-cyclodextrin (BCD) and with glucose have been examined using DSC, TG and TG-FTIR, complemented by X-ray powder diffraction (XRD) and infrared spectroscopic (IR) studies. Thermal studies of the solid TPH/BCD mixtures indicated that interaction between the components occurs and it is possible that the TPH molecule may be least partially accommodated in the cavity of the BCD host molecule. XRD results support this indication of inclusion. The results of molecular modelling suggest that TPH is most likely to be accommodated in the BCD cavity as a neutral triprolidine molecule with the toluene portion of the molecule preferentially included in the cavity. The results obtained illustrate the general stability of TPH. The study has also shown TPH to be compatible with both glucose and BCD, which are potential excipients both in solid and liquid dosage forms. The presence of these excipients in dosage forms will thus not adversely affect the stability and the therapeutic efficacy of TPH.

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Journal of Thermal Analysis and Calorimetry
Authors: Erika Szunyogová, Dagmar Mudroňová, Katarína Györyová, Radomíra Nemcová, Jana Kovářová, and Lenka Piknová-Findoráková

Abstract  

Spectroscopic (IR), thermoanalytical (TG/DTG, DTA) and biological methods were applied to investigate physicochemical and biological properties of seven zinc(II) complex compounds of the following formula Zn(HCOO)2·2H2O (I), Zn(HCOO)2·tph (II), Zn(CH3COO)2·2H2O (III), Zn(CH3COO)2·tph (IV), Zn(CH3COO)2·2phen (V), Zn(CH3CH2COO)2·2H2O (VI), Zn(CH3CH2CH2COO)2·2H2O (VII), where tph=theophylline, phen=phenazone. The formation of various intermediates during thermal decomposition suggests the dependence on the length of aliphatic carboxylic chain and type of N-donor ligand (tph, phen). The final product of the thermal decomposition was ZnO. The antimicrobial activity of these complexes were tested against G+ and G bacteria. Strong inhibitive effect was observed towards E. coli, salmonellae and Staph. aureus.

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Abstract  

Thermal decomposition of lanthanum nitrate to lanthanum oxide was carried out by both temperature programmed heating (TPH) and citrate-gel combustion. The temperature programmed heating was carried out under flow of oxidizing (air), neutral (nitrogen) and reducing (25 vol.% hydrogen+argone mixture) gases, and the processes were controlled by simultaneous thermogravimetry and differential thermal analysis. It was shown that hydrogen atmosphere helps to reduce temperatures of all decomposition steps. The results of TPH were utilized to check the nature of residues in the products of lanthanum nitrate-to-oxide conversion performed via citrate-gel combustion technique.

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Abstract

Risk assessments and remediation plans of hydrocarbon-contaminated sites usually have been managed based on total petroleum hydrocarbon (TPH) content. Gasoline is one of the most mobile pollution agents, which consist mainly of light hydrocarbons. Measuring of TPH does not give enough information about the individual compounds. Another problem is using solvents such as n-hexane for extraction. In some cases we would like to know about the hydrocarbon-adsorption properties of contaminated samples. The article describes a laboratory model for hydrocarbon contamination modeling, and measuring hydrocarbon sorption properties. For modeling the authors have chosen gasoline type hydrocarbon, homogeneous sand and clay samples from the Kiscell Clay Formation. Results of the modeling indicate that the referenced ATD-GC/MS method can be a very effective tool in the risk assessment of hydrocarbon-contaminated areas.

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Pollack Periodica
Authors: Kalman Buzas, Peter Budai, and Adrienne Clement

One and a half year long field sampling was established in order to evaluate the contamination of storm water runoff. The event means (EMC) total petroleum hydrocarbons (TPH) concentration of the runoff was a function of the actual traffic intensity and the rainfall depth. It was concluded that this TPH, of which dominant component is the engine-oil (characteristically C28) does not form an ‘oil-in-water’ type emulsion in the condition of normal motorway-operation, but is interlocked to asphalt, rubber and soot particles of maximum some ten microns size. This condition influences the possibility, way and extent of separation alike. The separation equipments and their sizing applied so far are not suitable to achieve efficient surface water protection. Practical prevention method of accidental type environment pollution was also suggested. On the basis of the international literature evaluation, technical solutions capable to decrease the runoff pollution were summarized. Among these, useful calculation method was developed for designers to determine the sufficient storage capacity (water quality volume) of reservoirs applied for water quality protection. Monitoring technique of runoffs, which are characterized time dependent, variable pollutant concentrations by their nature, was proposed. It was stated that the administrative regulation should aim at the EMC instead of current concentration. Beside TPH information was gained on polycyclic aromatic hydrocarbons (PAHs), suspended solids, heavy metals, pH, and nutrient (N, P) pollution of the runoff, which are valuable for the grounding of further research results.

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