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Abstract  

DMSA-coated Fe3O4 nanoparticles were synthesized by wet-chemical method. The chemical interaction between Fe3O4 and DMSA were investigated by FTIR. They were directly radiolabeled with 99mTc radioisotope (Fe3O4@DMSA–99mTc) at room temperature in the presence of stannous solution as a reducing agent. Magnetic and structure properties of Fe3O4@DMSA–99mTc nanoparticles were investigated by AGFM, TEM, and XRD. Biodistribution and toxicity assessment of Fe3O4@DMSA–99mTc were studied in mice by intravenous and intraperitoneally injections, respectively. Blood, kidney, and liver factors were measured 4 days post injection and at the mean-while tissue sections were prepared from their kidney and liver. The results indicate that, the Fe3O4@DMSA–99mTc nanoparticles were passed through the membrane of different cells but do not create any disorder in the kidney and liver function even in high doses such as 300 mg/kg.

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Acta Biologica Hungarica
Authors: Anna Sobeková, Katarína Holovská, Viera Lenártová, Slávka Flešárová, and P. Javorský

Bus, J. S., Gibson, J. E. (1984) Paraquat: model for oxidant-initiated toxicity. Environ. Health Persp. 55 , 37–46. Gibson J. E. Paraquat: model for oxidant-initiated toxicity

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Cereal Research Communications
Authors: S.A. Ghaffari Nejad, G.R. Savaghebi, M. Farahbakhsh, R. Maali Amiri, and H. Rezaei

toxicity . Plant Biol. 11 : 328 – 338 . Avci , M. , Akar , T. 2005 . Severity and spatial distribution of boron toxicity in barley cultivated areas of Central Anatolia and

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Halliwell, B. (1982) The toxic effects of oxygen on plant tissues. In: Oberley, L. W. (ed.) Superoxide Dismutase . CRC Press, Boca Raton, pp. 89-124. The toxic effects

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Literature 1 Anjum, F. and Wright, D. (2016): Relative toxicity of insecticides to the crucifer pests Plutella xylostella and Myzus persicae and their natural

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Acta Physiologica Hungarica
Authors: Teodora Mocan, S. Clichici, L. Agoşton-Coldea, L. Mocan, Ş Şimon, I. Ilie, A. Biriş, and Adriana Mureşan

25 Goodman CM, McCusker CD, Yilmaz T, Rotello VM: Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjugate Chem. 15, 897–900 (2004

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Cereal Research Communications
Authors: Antonio Logrieco, Antonio Moretti, Giuseppina Mule, Costantino Paciolla, and Alberto Ritieni

357 364 Fotso, J., Smith, J.S. 2003. Evaluation of beauvericin toxicity with the bacterial bioluminescence assay and the Ames mutagenicity bioassay. Journal of Food Science

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180 Hill, J. M. (1999): Nitrate toxicity: myth or reality. Br. J. Nutr. , 81 , 343. Hill J. M. Nitrate

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It has been established that the selected acetamide derivatives fulfill Veber’s and Pardridge’s rule of good bioavailability. The lipophilicity as a crucial molecular descriptor of biological activity for acetamide derivatives was determined by reversed-phase thinlayer chromatography (RP-TLC) in different mixtures of water and organic modifiers (ethanol and tetrahydrofuran). Also, lipophilicity was examined mathematically, by using relevant software packages. The effects of the substituent on the lipophilicity of acetamide derivatives were analyzed. By applying linear regression analysis and 2 multivariate methods (cluster analysis and principal component analysis), the obtained chromatographic parameters, R M 0 and m, of the examined acetamides were correlated with the standard measure of lipophilicity, log P, important pharmacokinetic predictors, and selected toxicity parameters. The obtained results confirmed that chromatographic parameters, R M 0 and m, determined by RP-TLC, could be successfully used for describing the lipophilicity and estimation of pharmacokinetics and the toxic effects of the studied acetamide derivatives.

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Orvosi Hetilap
Authors: Zsófia Jordán, Zsófia Tokodi, Ágnes Németh, Judit Müller, Mónika Csóka, Adrienn Mohl, Dániel Erdélyi, and Gábor Kovács

Wang, J. L., MA, S. Q., Zhang, Y. J., et al.: Role of single-breath carbon monoxide-diffusing capacity in monitoring the bleomycin-induced lung toxicity in human. Zhonghua Nei Ke Za Zhi, 2003, 42 , 709

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