Authors:S. Fatahian, D. Shahbazi-Gahrouei, M. Pouladian, M. Yousefi, Gh. Amiri, and A. Noori
DMSA-coated Fe3O4 nanoparticles were synthesized by wet-chemical method. The chemical interaction between Fe3O4 and DMSA were investigated by FTIR. They were directly radiolabeled with 99mTc radioisotope (Fe3O4@DMSA–99mTc) at room temperature in the presence of stannous solution as a reducing agent. Magnetic and structure properties of Fe3O4@DMSA–99mTc nanoparticles were investigated by AGFM, TEM, and XRD. Biodistribution and toxicity assessment of Fe3O4@DMSA–99mTc were studied in mice by intravenous and intraperitoneally injections, respectively. Blood, kidney, and liver factors were
measured 4 days post injection and at the mean-while tissue sections were prepared from their kidney and liver. The results
indicate that, the Fe3O4@DMSA–99mTc nanoparticles were passed through the membrane of different cells but do not create any disorder in the kidney and liver
function even in high doses such as 300 mg/kg.
Authors:Gyöngyi Vastag, Suzana Apostolov, Biljana Kaurinovic, and Ljubica Grbovic
It has been established that the selected acetamide derivatives fulfill Veber’s and Pardridge’s rule of good bioavailability. The lipophilicity as a crucial molecular descriptor of biological activity for acetamide derivatives was determined by reversed-phase thinlayer chromatography (RP-TLC) in different mixtures of water and organic modifiers (ethanol and tetrahydrofuran). Also, lipophilicity was examined mathematically, by using relevant software packages. The effects of the substituent on the lipophilicity of acetamide derivatives were analyzed. By applying linear regression analysis and 2 multivariate methods (cluster analysis and principal component analysis), the obtained chromatographic parameters, RM0 and m, of the examined acetamides were correlated with the standard measure of lipophilicity, log P, important pharmacokinetic predictors, and selected toxicity parameters. The obtained results confirmed that chromatographic parameters, RM0 and m, determined by RP-TLC, could be successfully used for describing the lipophilicity and estimation of pharmacokinetics and the toxic effects of the studied acetamide derivatives.
Authors:Zsófia Jordán, Zsófia Tokodi, Ágnes Németh, Judit Müller, Mónika Csóka, Adrienn Mohl, Dániel Erdélyi, and Gábor Kovács
Wang, J. L., MA, S. Q., Zhang, Y. J., et al.: Role of single-breath carbon monoxide-diffusing capacity in monitoring the bleomycin-induced lung toxicity in human. Zhonghua Nei Ke Za Zhi, 2003, 42 , 709