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UPLC-MS/MS method was developed for determination of calycanthine in rat plasma, and pharmacokinetics in rats was investigated. Materials and methods Chemical and animals Calycanthine (purity > 98%, Fig. 1A ) and midazolam (purity > 98%, Fig. 1B

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Authors: Jianbo Li, Yujie Hu, Yajin Wu, Tiantian Feng, Congcong Wen and Xiajuan Jiang

determination of palmatine in plasma [ 9–20 ]. Compared to HPLC and LC-MS/MS, UPLC-MS/MS is faster, possessing significant advantages in the investigation on pharmacokinetics of drugs [ 21–28 ]. Meanwhile, the powerful separation and analysis capacity is

Open access
Authors: Jinzhao Yang, Huamin Liu, Yuan Cai, Yazhen Wu, Xiaoxin Xu, Xianqin Wang and Chongliang Lin

-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the quantification of erlotinib in rat plasma. Then the UPLC-MS/MS method was successfully applied to effect of Citrus suavissima Hort. ex Tanaka on pharmacokinetics of erlotinib in

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Authors: Yongxi Jin, Yuyan Chen, Jiawen Liu, Xi Bao, Yinghao Zhi, Congcong Wen and Wenzong Zhu

–tandem mass spectrometry (UPLC–MS/MS) reported for the determination of ebeiedinone. To the best of our knowledge, the pharmacokinetics of ebeiedinone had not been reported. In this paper, UPLC–MS/MS method was established to determine ebeiedinone in mouse

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Authors: Haiya Wu, Mengrou Lu, Jiamin He, Miaoling Huang, Aote Zheng, Meiling Zhang, Congcong Wen and Jufen Ye

chromatography–tandem mass spectrometer (LC–MS/MS), ultra-performance LC–MS/MS (UPLC–MS/MS) has higher detection sensitivity with more powerful separation and analytical capability, which are essential for studying Chinese medicine with complex contents and the

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Authors: Aixia Han, Guanyang Lin, Jinzhang Cai, Qing Wu, Peiwu Geng, Jianshe Ma, Xianqin Wang and Chongliang Lin

reported the pharmacokinetics of hirsutine and hirsuteine. Wu et al. [ 15 ] established an ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method to simultaneously measure rhynchophylline and hirsutine in rat plasma and also

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Authors: Yunfang Zhou, Bingbao Chen, Junyan Chen, Yanwen Dong, Shuanghu Wang, Congcong Wen, Xianqin Wang and Xiaomin Yu

pH using the mixture of acetonitrile and 0.1% formic acid (45:55, v / v ) as a mobile phase. The analytical run time was 3.5 min. In this paper, an ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method with an

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Authors: Peiwu Geng, Jing Zhang, Bingbao Chen, Qianqian Wang, Shuanghu Wang and Congcong Wen

conventional analytical techniques, ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC–MS/MS) is documented to possess improved sensitivity, selectivity, and specificity in quantitative determination of the active compound of

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Authors: Quan Zhou, Zhiguang Zhang, Peiwu Geng, Bingge Huang, Xianqin Wang and Xiaomin Yu

isocratic mobile phase consisting of acetonitrile–water–formic acid (75:25:0.1, v / v ). The ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method that we developed focused on the analytical ability for ligustroflavone in rat

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Authors: Qinghua Weng, Lianguo Chen, Luxin Ye, Xiaojie Lu, Zheng Yu, Congcong Wen, Yichuan Chen and Gang Huang

reported. Compared with capillary-zone electrophoresis, HPLC, and LC–MS, an ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was more sensitive, high throughput, and time saving [ 16 – 20 ]. In this study

Open access