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Resolution of the enantiomers of racemic atenolol, metoprolol, propranolol, and labetalol, commonly used β-blockers, has been achieved by TLC on silica gel plates using vancomycin as chiral impregnating reagent or as chiral mobile phase additive. With vancomycin as impregnating agent, successful resolution of the enantiomers of atenolol, metoprolol, propranolol, and labetalol was achieved by use of the mobile phases acetonitrile-methanol-water-dichloromethane 7:1:1:1 ( v/v ), acetonitrile-methanol-water 6:1:1 ( v/v ), acetonitrile-methanol-water-dichloromethane-glacial acetic acid 7:1:1:1:0.5 ( v/v ), and acetonitrile-methanol-water 15:1:1 ( v/v ), respectively. With vancomycin as mobile phase additive, successful resolution of the enantiomers of metoprolol, propranolol, and labetalol was achieved by use of the mobile phases acetonitrile-methanol-0.56 mM aqueous vancomycin (pH 5.5) 6:1:1 ( v/v ), acetonitrile-methanol-0.56 mM aqueous vancomycin (pH 5.5) 15:1:2 ( v/v ), and acetonitrile-methanol-0.56 mM aqueous vancomycin (pH 5.5)-dichloromethane 9:1:1.5:1 ( v/v ), respectively. Spots were detected by use of iodine vapor. The detection limits were 1.3, 1.2, 1.5, and 1.4 μg for each enantiomer of atenolol, metoprolol, propranolol, and labetalol, respectively.

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Acta Microbiologica et Immunologica Hungarica
Authors: Máté Szász, Mária Hajdú, Natasa Pesti, Mónika Domahidy, Katalin Kristóf, ákos Zahár, Károly Nagy, and Dóra Szabó

.M., Composto, R.J., Freeman, T.A., Wickstrom, E., Ducheyne, P., Jungkind, D., Shapiro, I.M., Hickok, N.J.: The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic

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, Werner G: Vancomycin-resistente Enterokokken (VRE). Aktuelle Daten und Trends zur Resistenzentwicklung. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 55, 1387–1400 (2012) Werner G

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Acta Microbiologica et Immunologica Hungarica
Authors: Sajith Vellappally, Darshan Devang Divakar, Abdulaziz Abdullah Al Kheraif, Ravikumar Ramakrishnaiah, Amer Alqahtani, M. H. N. Dalati, Sukumaran Anil, Aftab Ahmed Khan, and P. R. Harikrishna Varma

increased concern and a major pathogen of hospital-acquired infections [ 1, 2 ]. Vancomycin was considered to be the best alternative for the treatment of multidrug-resistant MRSA. However, there have been increasing reports of vancomycin-resistant S

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most frequently encountered bacterial species in microbiology laboratories in Nigeria [ 6 , 7 ]. Molecular data on this pathogen in Nigeria is however very limited. As early as 1950, vancomycin, the first glycopeptide antibiotic to be

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Hryniewicz, W., Szczypa, K., Bronk, M., Samet, A., Hellmann, A., Trzcinski, K.: First report of vancomycin-resistant Enterococcus faecium isolated in Poland. Clin Microbiol Infect 5 , 503-505 (1999

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species most frequently isolated from clinical samples ( Maasjost et al., 2009 ) and cloacal samples of poultry ( Ünal et al., 2017; Aslantaş, 2019 ). Glycopeptides (such as vancomycin and teicoplanin) are effective antibiotics for the treatment of Gram

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-type vancomycin-resistant enterococci on Norwegian poultry farms three years after avoparcin was banned. J. Appl. Microbiol. 89 , 478–485. Kruse H. Continuing high prevalence of VanA

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