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Chevallier, J. Loschak, D. (1982): Rationalite Juridique et rationalite manageriale dans l'Administration Francaise. Revue Francaise d'Administration Publique , 24 : 14
Performance 2008 Cepiku, Denita — Meneguzzo, Marco (2007): Public Administration Education in Italy: A Statistical Analysis
Administration Management]. Cluj-Napoca: Accent. Gutierrez Rodriguez P. Management si leadership in sectorul public in Managementul administratiei publice
Literature Beblavý , M. , ‘ Management of Civil Service Reform in Central Europe ’ in G Peteri (ed), Mastering Decentralization and Public Administration
Paradise: Treasures from the Forbidden City 2010 Berman, E. M. (2010): Public Administration in East Asia: Common Roots, Ways
Abstract
The U.S. Food and Drug Administration (FDA) is responsible for the wholesomeness of the nation's food supply. The FDA modified its food monitoring program in January, 1973, to include radioactive isotopes. The methodology used to perform, analyses on these food products are taken from the standerd setting societies such as the AOAC International, American Society for Testing Materials and American Public Health Association Standard Methods. In addition, methods not tested by these societies are taken from the literature or from Department of Energy manuals such as the Health and Safety Laboratory and also from Environmental Protection Agency, Public Health Service, and Food and Agricultural Organization manuals. These include the methods for long-lived radionuclides such as tritium, strontium-90, cesium-137 and plutonium. Also, the short-lived radionuclides such as iodine-131, radiocesium, radiocerium and radioruthenium. In addition, they include the natural occurring radionuclides such as radium and uranium isotopes. The activity concentrations of gamma-emitters such as radiocesium, iodine-131 and radioruthenium are determined by gamma-ray spectrometry. This is done using intrinsic germanium detectors with the appropriate hardware and software. The alpha and “pure” beta-emitters are determined by various radiochemical methods and techniques. The radiochemical methodology and equipment used in analyzing these radionuclides are described and discussed. Also, the methodology and equipment for the gamma-emitters are described in more detail in this paper. In addition, the limits of detection for the methods used will be discussed.
Summary
Dauricine has a variety of pharmacological properties including anti-inflammatory, anti-arrhythmic, and antihypertensive effects as well as reversing multidrug resistance (MDR) of cancer cells. While its therapeutic application is increasing, its bioavailability of different administration routes has not been studied. In the present study, we developed and validated a liquid chromatography/electrospray ionization mass spectrometry method (LC-MS/MS). Using this method, we quantified dauricine in rat plasma after administration via intravenous (i.v.) injection, per oral (p.o.), and intraperitoneal injection (i.p.). Our results indicated that this method detected plasma dauricine with a good linearity in the range of 1.95–1000.00 ng/mL (r = 0.9997). The extraction method showed an average intra- and inter-day recovery of 98.21–104.35% and 98.0–103.58%, respectively. Dauricine showed a fast absorption and widespread distribution after administration in all three tested routes. After intravenous administration (2.5, 5.0, 10.0 mg/kg), the pharmacokinetics of dauricine exhibited a first-order kinetics. In addition, dauricine showed a slow elimination with a long half-life (t 1/2z) and double peaks phenomenon following p.o. and i.p. administration. Furthermore, using area under the plasma concentration-time curve (AUC), we calculated absolute bioavailability, which was over twofold higher when administered via i.p. than via p.o. administration. The newly obtained information from our study will provide important reference for dauricine dose and administration route in designing dauricine therapy for applicable diseases.
Public Sector Size . COCOPS Working Paper 4 . Arellano-Gault , D. ( 2010 ): Economic-NPM and the Need to Bring Justice and Equity Back to the Debate on Public Organizations . Administration
[Geography of Hungarian Public Administration]. Budapest-Pécs: Dialóg Campus. Hajdú Z. Magyarország közigazgatási földrajza 2005
közigazgatás és területfejlesztés asszimmetriái [Asymmetries of Slovakian public administration and spatial development]. Tér és Társadalom 4. Olsson, J. (2001): Democracy Paradoxes in Multi-level Governance . RSA
