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degradants, measuring the content of active ingredient accurately [ 1 , 2 ]. Alpha-lipoic acid (ALA), also known as thioctic acid, was discovered in 1951 as a molecule with potent antioxidant activity which assists in transfer of acyl-group and acts as a

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A diabeteses cardiovascularis autonóm neuropathia klinikuma, diagnosztikája és terápiája

Diabetic cardiovascular autonomic neuropathy: clinical significance, diagnosis and therapy

Orvosi Hetilap
Authors:
Péter Kempler
and
Anna Körei

. Morbidity and mortality of patients with diabetic neuropathy treated with pathogenetically oriented alpha-lipoic acid versus symptomatic pharmacotherapies – a nationwide database analysis from

Open access

polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis. Diabetic Med., 2004, 21 , 114–121. Kempler P. Treatment of symptomatic diabetic polyneuropathy with the antioxidant

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This study was performed to determine the possible ameliorative effect of alpha-lipoic acid (LA) against oxidative stress evoked by lead (Pb) toxicity on 5-d wheat seedlings and elucidate how this ameliorative process was mediated. Pb toxicity caused a significant reduction in early seedling growth as evidenced by stunted root and coleoptile growth. To cope with the Pb toxicity, the activities of antioxidant enzymes were significantly stimulated compared to the control. However, in spite of high activities of these enzymes, contents of reactive oxygen species (ROS), superoxide anion and hydrogen peroxide and lipid peroxidation level were significantly high compared with the control. Similarly, Pb toxicity caused a marked decrease in the level of reduced forms of ascorbate and glutathione and thus it changed their reduced/oxidized ratio in favor of oxidized forms. On the other hand, LA supplementation further promoted uptake, accumulation, and transportation of Pb by stimulating tolerance mechanism involving ion uptake/accumulation at a high level. Moreover, ROS content and lipid peroxidation level were recorded as lower than that of the stressed-ones alone. In addition, while Pb toxicity markedly reduced amylase activity by decreasing Ca2+ content in endosperms, LA supplementation mitigated the reduction in amylase activity by increasing Ca2+ content. The changes in amylase activity were supported by isozymes patterns. Taken together, LA carried out its ameliorative effect against Pb toxicity via stimulation of tolerance mechanism, and this mechanism was linked to regeneration of the other main antioxidant compounds due to its own antioxidant property instead of activation of antioxidant enzymes.

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Hungarian Medical Journal
Authors:
Solomon O. Ugoya
,
Mayowa O. Owolabi
,
Tokunbo A. Ugoya
,
Fabian H. Puepet
,
Godwins O. Echejoh
, and
Adesola Ogunniyi

232 Ziegler, D.: Treatment of Symptomatic Diabetic Peripheral Neuropathy with the antioxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study

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. 9. Cho , Y. S. , Lee , J. , Lee , T. H. , Lee , K. U. , Park , J. Y. , Moon , H. B. ( 2002 ) Alpha-lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of

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Orvosi Hetilap
Authors:
Zoltán Kender
,
Péter Torzsa
,
Vince Grolmusz K.
,
Attila Patócs
,
Adrienn Lichthammer
,
Márta Veresné Bálint
,
Károly Rácz
, and
Péter Reismann

22 1543 1548 Kunt, T., Forst, T., Wilhelm, A., et al.: Alpha-lipoic acid reduces expression of vascular cell adhesion molecule-1 and

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. ( 2018 ): The effects of chronic smoking on lung tissue and the role of alpha lipoic acid , Biotech. Histochem. 93 , 526 – 535 . 10.1080/10520295.2018.1479885 Pepe , M. S. , Etzioni , R. , Feng , Z. , Potter , J. D. , Thompson , M. L

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, Fantus IG , Couture R : Effects of alpha-lipoic acid on oxidative stress and kinin receptor expression in obese zucker diabetic fatty

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Acta Veterinaria Hungarica
Authors:
Benjámin Kövesi
,
Szabina Kulcsár
,
Mátyás Cserháti
,
Márta Erdélyi
,
Zsolt Ancsin
,
Erika Zándoki
,
Miklós Mézes
, and
Krisztián Balogh

. , Onder , F. and Ozcan , K. ( 2010 ): Pathological, biochemical and haematological investigations on the protective effect of alpha-lipoic acid in experimental aflatoxin toxicosis in chicks . Br. Poult. Sci. 51 , 132 – 141 . 10

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