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Bérdy, J.: Thoughts and facts about antibiotics: Where we are now and where we are heading. J. Antibiot. (Tokyo), 2012, 65 , 385–395. Bérdy J

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desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and 16S rRNA sequencing in the routine diagnostic workflow of microbiology laboratories [ 11 ]. The aim of this study was to describe the prevalence and antibiotic susceptibility patterns

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now being found to be contaminated with various xenobiotics such as antibiotics, pesticides, and acaricides. The non-judicious use of antibiotics against bacterial foulbrood diseases of honey bees often lead to contamination of honey. The contaminated

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over a period of several weeks to months, depending on the production method [ 1 , 2 ] (Figure 1 ). Figure 1. Preserved egg sliced open Antibiotics, mainly macrolides

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Acta Microbiologica et Immunologica Hungarica
Authors: Aleksandra Šmitran, Dragana Vuković, Nataša Opavski, Ina Gajić, Jelena Marinković, Ljiljana Božić, Irena Živanović, Dušan Kekić, Sunčica Popović, and Lazar Ranin

In this study, the focus was on the effects of sub-MICs of the antibiotics on adherence, hydrophobicity, and biofilm formation by two groups of Streptococcus pyogenes strains, which were responsible for different clinical cases. The aim of this study was to explore the effects of sub-MICs of penicillin, ceftriaxone, erythromycin, and clindamycin on adherence, surface hydrophobicity, and biofilm biomass in two selected collections of group A streptococcus (GAS): strains isolated from carriers (CA) and strains isolated from patients with tonsillopharyngitis (TPh). Isolates were tested for hydrophobicity to xylene, adherence, and biofilm production in uncoated microtiter plates before and after treatment with 1/2 and 1/4 MICs of antibiotics. Penicillin reduced adherence and biofilm production in TPh strains, whereas ceftriaxone diminished adherence and biofilm formation in CA group. On the contrary, clindamycin enhanced adherence and biofilm production in both groups of strains. Erythromycin did not significantly alter adherence, but triggered biofilm production in both groups of isolates. Hydrophobicity of both groups of strains was significantly reduced after exposure to all antibiotics. Beta-lactams displayed anti-biofilm activity; penicillin diminished both adherence and biofilm production in TPh strains, whereas ceftriaxone reduced it in strains isolated from CA.

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This study performed an epidemiological survey of Neisseria meningitidis strains isolated from patients and from asymptomatic carriers. Altogether, 74 N. meningitidis strains (46 invasive and 28 non-invasive) were isolated between February 2011 and May 2018 in different regions of the Republic of Belarus. Serogenotyping was carried out by real-time PCR. Minimum inhibitory concentrations (MICs) of antibiotics were determined by broth microdilution and results were interpreted in accordance with EUCAST. The serogroups of N. meningitidis were determined as follows: serogroup B – 65%, C – 11%, W – 9%, A – 5%, Y – 4%, and Z and NG – 3% each. The MIC50 and MIC90 for benzylpenicillin (0.032/0.064–0.125 mg/L), ampicillin (0.032/0.125 mg/L), amoxicillin (0.125/0.25 mg/L), cefotaxime (0.016/0.016 mg/L), ceftriaxone (0.002/0.016 mg/L), ciprofloxacin (0.004/0.008 mg/L), chloramphenicol (1/1 mg/L), meropenem (0.008/0.008–0.016 mg/L), tetracycline (0.25/0.5 mg/L), and rifampicin (0.016/0.25 mg/L) were established. Strains with intermediate susceptibility for benzylpenicillin (12.3%), ampicillin (6.8%), and amoxicillin (24.7%) have been identified. In this study, we report the first rifampicin-resistant N. meningitidis in Belarus.

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Az erysipelas (orbánc) a bőr heveny, fertőzéses eredetű gyulladása, amelyet leggyakrabban Streptococcus pyogenes okoz. Az erysipelas szövődményes formáit a nemzetközi irodalom a komplikált bőr- és lágyrész-infekciók közé so rolja. Szövődményes orbánc esetén a klinikai tünetek vagy a kísérő betegségek alapján a szokottnál súlyosabb lefo lyású a betegség. Ilyen esetekben a kórokozók között a Gram-pozitív coccusok mellett Gram-negatív baktériumokra és obligát anaerob patogének jelenlétére is számítani kell. Célok: A vizsgálat célkitűzése a Szegedi Tudományegyetem, Bőrgyógyászati és Allergológiai Klinikára felvételre került betegek kezelése során alkalmazott empirikus antibiotikum-terápiák hatékonyságának összehasonlítása volt. Az antibiotikus kezelést a klinika munkatársai empirikus alapon, előre meghatározott protokoll alapján kezdték el. Módszerek: A vizsgálatban a szerzők 158 fekvő beteg adatait dolgozták fel. Értékelték a mikrobiológiai mintavételeket és a tenyésztések eredményeit is. Eredmények és következtetések: Eredményeik szerint az erysipelas kezelésében továbbra is a penicillin az elsőként választandó kezelés. A szövődményes formákban a nemzetközi ajánlásokban is szereplő kombinált, széles spektrumú antibiotikumok alkalmazását javasolják a szerzők. Orv. Hetil., 2011, 152, 252–258.

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Treated mastitis episodes at large Hungarian dairy farms were studied to determine the distribution of mastitis treated with antibiotics among quarters of the udder. Data were detailed records of all mastitis episodes that occurred during 1976 lactations in Farm A infected with Staphylococcus aureus (from May 1995 through July 1998) and 808 lactations in Farm B free from S. aureus (from January 1999 through March 2001). The distribution of treated quarters was compared with mathematical expectations based upon a random distribution in the case of Farm A. Results on mastitis incidences for different lactation stage groups showed an increasing incidence within subsequent lactation stage groups in Farm A. In contrast, in Farm B the mastitis incidence for lactation stage group between 35 and 100 days was the highest, but beyond 100 days the incidence decreased and reached the lowest value. Results gave strong evidence that the four quarters within the udder are not distributed randomly with respect to naturally occurring episodes of treated mastitis. More episodes than expected occurred in which only one or all four quarters were treated. Fewer episodes than expected with two or three treated quarters were observed. In both farms, the mastitis rate for rear quarters was higher than for front quarters, and the incidence of right quarter mastitis episodes was higher than that of left quarter mastitis episodes.

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Introduction Extended spectrum β-lactamases (ESBLs) are enzymes produced by a variety of Gram-negative bacteria which confer an increased resistance to commonly used antibiotics, such as the penicillins and the cephalosporins

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Acta Microbiologica et Immunologica Hungarica
Authors: Nina Bulajić, Biljana Miljković-Selimović, Zoran Tambur, Branislava Kocić, Katarina Kalevski, and Ema Aleksić

, dog breeding has emerged as an additional risk factor for human campylobacteriosis [ 1 ]. Antibiotic treatment of human campylobacteriosis Human campylobacteriosis is a self-limiting gastroenteritis with diarrhoea

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