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Bérdy, J.: Thoughts and facts about antibiotics: Where we are now and where we are heading. J. Antibiot. (Tokyo), 2012, 65 , 385–395. Bérdy J

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Acta Microbiologica et Immunologica Hungarica
Authors: Aleksandra Šmitran, Dragana Vuković, Nataša Opavski, Ina Gajić, Jelena Marinković, Ljiljana Božić, Irena Živanović, Dušan Kekić, Sunčica Popović, and Lazar Ranin

antimicrobial therapy for TPh. Biofilm formation has been suggested as an important aspect of the carrier (CA) state and antibiotic treatment failures [ 3 ]. The ability of GAS to form biofilm was recently recognized as an important virulence trait of the

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. Meningococcal infection surveillance in the Republic of Belarus Rational antibiotic therapy and chemoprophylaxis allow to prevent complications in patients with meningococcal infection, as well as to reduce the transmission of

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desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and 16S rRNA sequencing in the routine diagnostic workflow of microbiology laboratories [ 11 ]. The aim of this study was to describe the prevalence and antibiotic susceptibility patterns

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now being found to be contaminated with various xenobiotics such as antibiotics, pesticides, and acaricides. The non-judicious use of antibiotics against bacterial foulbrood diseases of honey bees often lead to contamination of honey. The contaminated

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over a period of several weeks to months, depending on the production method [ 1 , 2 ] (Figure 1 ). Figure 1. Preserved egg sliced open Antibiotics, mainly macrolides

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Az erysipelas (orbánc) a bőr heveny, fertőzéses eredetű gyulladása, amelyet leggyakrabban Streptococcus pyogenes okoz. Az erysipelas szövődményes formáit a nemzetközi irodalom a komplikált bőr- és lágyrész-infekciók közé so rolja. Szövődményes orbánc esetén a klinikai tünetek vagy a kísérő betegségek alapján a szokottnál súlyosabb lefo lyású a betegség. Ilyen esetekben a kórokozók között a Gram-pozitív coccusok mellett Gram-negatív baktériumokra és obligát anaerob patogének jelenlétére is számítani kell. Célok: A vizsgálat célkitűzése a Szegedi Tudományegyetem, Bőrgyógyászati és Allergológiai Klinikára felvételre került betegek kezelése során alkalmazott empirikus antibiotikum-terápiák hatékonyságának összehasonlítása volt. Az antibiotikus kezelést a klinika munkatársai empirikus alapon, előre meghatározott protokoll alapján kezdték el. Módszerek: A vizsgálatban a szerzők 158 fekvő beteg adatait dolgozták fel. Értékelték a mikrobiológiai mintavételeket és a tenyésztések eredményeit is. Eredmények és következtetések: Eredményeik szerint az erysipelas kezelésében továbbra is a penicillin az elsőként választandó kezelés. A szövődményes formákban a nemzetközi ajánlásokban is szereplő kombinált, széles spektrumú antibiotikumok alkalmazását javasolják a szerzők. Orv. Hetil., 2011, 152, 252–258.

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Treated mastitis episodes at large Hungarian dairy farms were studied to determine the distribution of mastitis treated with antibiotics among quarters of the udder. Data were detailed records of all mastitis episodes that occurred during 1976 lactations in Farm A infected with Staphylococcus aureus (from May 1995 through July 1998) and 808 lactations in Farm B free from S. aureus (from January 1999 through March 2001). The distribution of treated quarters was compared with mathematical expectations based upon a random distribution in the case of Farm A. Results on mastitis incidences for different lactation stage groups showed an increasing incidence within subsequent lactation stage groups in Farm A. In contrast, in Farm B the mastitis incidence for lactation stage group between 35 and 100 days was the highest, but beyond 100 days the incidence decreased and reached the lowest value. Results gave strong evidence that the four quarters within the udder are not distributed randomly with respect to naturally occurring episodes of treated mastitis. More episodes than expected occurred in which only one or all four quarters were treated. Fewer episodes than expected with two or three treated quarters were observed. In both farms, the mastitis rate for rear quarters was higher than for front quarters, and the incidence of right quarter mastitis episodes was higher than that of left quarter mastitis episodes.

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Exploring antibiotic resistant mechanism by microcalorimetry

Determination of thermokinetic parameters of metallo-β-lactamase L1 catalyzing penicillin G hydrolysis

Journal of Thermal Analysis and Calorimetry
Authors: Hui-Zhou Gao, Qi Yang, Xiao-Yan Yan, Zhu-Jun Wang, Ji-Li Feng, Xia Yang, Sheng-Li Gao, Lei Feng, Xu Cheng, Chao Jia, and Ke-Wu Yang

Introduction The overuse of antibiotics in the clinical setting has resulted in a large number of bacteria with metallo-β-lactamases (MβLs) including recently reported New Delhi metallo-β-lactamase 1 (NDM-1), which is resistant

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Exploring antibiotic resistant mechanism by microcalorimetry II

Determination of thermokinetic parameters of imipenem hydrolysis with metallo-β-lactamase ImiS

Journal of Thermal Analysis and Calorimetry
Authors: Xia Yang, Lei Feng, Kang-Zhen Xu, Hui-Zhou Gao, Chao Jia, Cheng-Cheng Liu, Jian-Min Xiao, Le Zhai, Li-Sheng Zhou, and Ke-Wu Yang

Introduction β-lactam antibiotics have been used for several decades, and the bacterial resistance to antibiotics is growing clinical concern [ 1 , 2 ]. Bacterial resistance to β-lactam-containing antibiotics is accomplished

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