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Biologia Futura
Authors:
Esra Aciman Demirel
,
Mumin Alper Erdoğan
,
Bilge Piri Cinar
, and
Oytun Erbas

more sensitive than i.p. PTZ administration ( Durlach-Misteli & Van Ree, 1992 ). The anticonvulsant effect of agomelatine in seizures induced by pilocarpine and PTZ in female rats was first shown by Aguiar et al. ( 2012 ). Their study showed a

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Grape seed extract (GSE) has been known as being neuroprotective due to its antioxidant properties. The aim of the present study was to examine both the effect of GSE on the penicillin-induced epileptiform activity in rat and the role of nitric oxide (NO) pathway in the effect of GSE. GSE, at doses of 50, 100, 200 mg/kg, significantly decreased the mean frequency of epileptiform activity. GSE, at the highest dose (400 mg/kg), did not change either the frequency or amplitude of epileptiform activity. GSE, at a dose of 200 mg/kg, was the most effective in changing the frequency of epileptiform activity. The occurrence of anticonvulsant activity of GSE was significantly delayed in the presence of selective inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (60 mg/kg), which was inhibited by the NO precursor, L-arginine (500 mg/kg). The administration of a non-selective NOS inhibitor, NG-nitro-L-arginine methyl ester (L-NAME) partially reversed the anticonvulsant activity of GSE. Selective neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole (7-NI) and L-arginine showed a similar anticonvulsant activity in the presence of GSE. The electrophysiological evidence of the present study indicates that GSE decreases the mean frequency of penicillin-induced epileptiform activity, suggesting an anticonvulsant role. iNOS/NO pathway could be involved in mediating anticonvulsant effect of GSE on the epileptiform activity.

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Acta Biologica Hungarica
Authors:
Barbara Barna
,
A. Szász
,
T. Asztalos
,
Z. Szupera
,
L. Vécsei
,
Helmi Houtzager
, and
Magdolna Szente

Löscher, W. (1986) Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils. Pharmacol. Biochem. Behav. 24 , 1007-1013. Development of tolerance to the anticonvulsant effect

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-Gómez , J. , Mercado-Gómez , O.F. , Vázquez-García , M. , Rodríguez-Molina , V , and Guevara-Guzmán , R. ( 2016 ). Anticonvulsant effect of time-restricted feeding in a pilocarpine-induced seizure model: metabolic and epigenetic implications

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ancient Egypt . Ithaca, NY : Cornell University Press . Sayyah , M. , & Mandgary , A. ( 2003 ). Anticonvulsant effect of

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