Authors:Elena Nikolaevna Filatova, Elena Viktorovna Anisenkova, Nataliya Borisovna Presnyakova, and Oleg Vladimirovich Utkin
herpesvirus type 6. They are lymphotropic viruses that can affect the functional state of the cells of the immune system. In particular, they cause anergy of T-lymphocytes and regulate proliferation and apoptosis of immunocompetent cells  .
. , Musarrat , J. and Al-Khedhairy , A. A. ( 2012 ): Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2 . Toxicol. Appl. Pharm. 259 , 160 – 168
Authors:M. Mahmoudabady, Saeed Niazmand, M. Shafei, and K. McEntee
Communal C, Colucci WS: The control of cardiomyocyte apoptosis via the beta-adrenergic signaling pathways. Arch. Mal. Coeur. Vaiss. 98, 236–241 (2005)
The control of cardiomyocyte apoptosis via the beta
Authors:Olga Jablonska, Joanna Piasecka-Srader, Anna Nynca, Agnieszka Kołomycka, Anna Robak, Barbara Wąsowska, and Renata Ciereszko
Bannerman, D. D., Tupper, J. C., Rickets, W. A., Bennet, C. F., Winn, R. K. and Harlan, J. M. (2001): A constitutive pathway protects endothelial cells from lipopolysaccharide-induced apoptosis. J. Biol. Chem. 276 , 14924
Authors:F. Ahmadabadi, M. Saghebjoo, M. Hedayati, R. Hoshyar, and C.-J. Huang
breast cancer as an alternative approach with minimal side effects [ 6 ]. In particular, Crocus sativus L., commonly known as saffron, has anti-cancer and anti-metastatic properties to promote apoptosis in different cancer cell lines [ 7 ]. Apoptosis is
Authors:Ewa L. Gregoraszczuk, Agnieszka Rak, Anna Wójtowicz, Anna Ptak, Tatiana Wojciechowicz, and K. W. Nowak
Leptin (L) is recognised as an important regulator of puberty and a factor which controls reproduction. Whole pig ovarian follicles were incubated with different doses of leptin (2, 20 and 200 ng/ml) added alone or in combination with 100 ng/ml of GH or 50 ng/ml of IGF-I. The expression of the functional long form leptin receptor (Ob-Rb) mRNA was examined by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) in follicular cells cultured with GH or IGF-I. Both GH and IGF-I increased leptin receptor expression in prepubertal pig ovaries. In separate experiments, the action of leptin on ovarian follicular steroidogenesis and cell apoptosis was examined. After 24 h of incubation with leptin alone or in combination with GH or IGF-I, oestradiol (E2) levels were determined in the culture medium while follicular tissue was used for the estimation of caspase-3 activity. Leptin increased E2 secretion and significantly diminished caspase-3 activity at all doses used. Both GH and IGF-I stimulated oestradiol secretion and decreased caspase-3 activity. No differences were demonstrable in oestradiol secretion and caspase-3 activity between cells treated with GH plus leptin and GH alone or cells treated with IGF-I plus leptin as compared to cultures treated with GH or IGF-I alone. However, GH diminished leptin-stimulated oestradiol secretion while IGF-I was without effect on it. Both GH and IGF-I reversed the anti-apoptotic action of leptin. In conclusion, we infer that (1) leptin directly affects ovarian function in prepubertal animals by its action on oestradiol secretion and cell apoptosis, (2) GH and IGF-I modulate the action of leptin, and (3) at least in part, the direct effect of GH/IGF-I on leptin production is due to an action on leptin receptor expression.
Authors:M. Alutis, U. Grundmann, A. Fischer, A. Kühl, S. Bereswill, and M. Heimesaat
Increased levels of the matrix metalloproteinases-2 and -9 (also referred to gelatinase-A and -B, respectively) can be detected in intestinal inflammation. We have recently shown that selective gelatinase blockage by the synthetic compound RO28-2653 ameliorates acute murine ileitis and colitis. We here investigated whether RO28-2653 exerts anti-inflammatory effects in acute Campylobacter jejuni-induced enterocolitis of gnotobiotic IL-10−/− mice generated following antibiotic treatment. Mice were perorally infected with C. jejuni (day 0) and either treated with RO28-2653 (75 mg/kg body weight/day) or placebo from day 1 until day 6 post infection (p.i.) by gavage. Irrespective of the treatment, infected mice displayed comparable pathogen loads within the gastrointestinal tract. Following RO28-2653 administration, however, infected mice exhibited less severe symptoms such as bloody diarrhea as compared to placebo controls. Furthermore, less distinct apoptosis but higher numbers of proliferating cells could be detected in the colon of RO28-2653-treated as compared to placebo-treated mice at day 7 p.i. Remarkably, gelatinase blockage resulted in lower numbers of T- and B-lymphocytes as well as macrophages and monocytes in the colonic mucosa of C. jejuni-infected gnotobiotic IL-10−/− mice. Taken together, synthetic gelatinase inhibition exerts anti-inflammatory effects in experimental campylobacteriosis.