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McGill, H. C. Jr., McMahan, C. A., Zieske, A. W., et al.: Association of coronary heart disease risk factors with microscopic qualities of coronary atherosclerosis in youth. Circulation, 2000, 102 (4
The inability of traditional risk factors such as hypercholesterolemia, hypertension, and smoking to explain the incidence of atherosclerosis (AT) in about 50% of the cases prompted a search for additional putative risk factors involved in the development of the disease. Infectious agents have long been suspected to initiate/contribute to the process of AT. It has also been suggested that inflammation, either related to infectious agents or independent from infection, may mediate the atherogenic process [1, 2].
References 1. L. Szollár 2005 Kórélettan Az atherosclerosis
Introduction Atherosclerosis is a chronic immune inflammatory disease of the arterial walls characterized by formation of atherosclerotic plaques [ 1 ]. The major clinical manifestations of the disease are peripheral arterial disease, ischemic heart
Introduction Atherosclerosis is a disease related to the alteration of the endothelium (intima), with the accumulation of white blood cells. Furthermore, smooth muscle cells migrate to the intima facilitating the formation of
The aim of this study was to investigate the iron concentrations in serum and carotid plaque in patients with different morphology of carotid atherosclerotic plaque and compared with other metal ions. Carotid endarterectomy due to the significant atherosclerotic stenosis was performed in 91 patients. Control group consisted of 27 patients, without carotid atherosclerosis. Atherosclerotic plaques were divided into four morphological groups, according to ultrasonic and intraoperative characteristics. Iron, copper and zinc concentration in plaque, carotid artery and serum were measured by spectrophotometry. Serum iron concentrations were higher in patients with hemorrhagic plaques in comparison to the control group (4.7 μmol/l ± 1.2 vs. 2.1 μmol/l ± 0.8, p < 0.05). Iron concentrations were higher in patients with hemorrhagic plaques in comparison to fibrolipid plaques (72.1 ± 14.3 μg/g vs. 39.3 ± 22.9 μg/g; p < 0.05). Negative significant correlation was found for zinc in serum and plaque iron concentration in patients (p < 0.05). We also demonstrated positive significant correlation for copper and iron in serum (p < 0.05). The data obtained in the current study are consistent with the hypothesis that high iron levels may contribute to atherosclerosis and its complications as factors in a multifactorial disease.
Taskinen, M. R., Borén, J.: New insights into the pathophysiology of dyslipidemia in type 2 diabetes. Atherosclerosis, 2015, 239 (2), 483–495. 12 Do, R., Stitziel
, no clear pattern was discovered in women [ 3 ]. The meta-analysis of 11 studies was an indication that there was an inverse relationship between increased bilirubin concentrations and atherosclerosis severity in men. There was a 6.5% decrease in
References 1 Márk L, Harangi M, Becker D. Atherosclerosis, unstable plaque, acute coronary syndrome. [Ateroszklerózis, instabil plakk, akut koronária szindróma
, diffuse atherosclerosis, and endothelial dysfunction [3–6] . Occlusive disease of the small coronary arteries, which may be a form of early phase atherosclerosis, has also been suggested as a cause [7] . Moreover, SCF may cause transient myocardial
