Authors:Taesik Yun, Yoonhoi Koo, Sanggu Kim, Hakhyun Kim, Soochong Kim, Ji-Houn Kang, Mhan-Pyo Yang and Byeong-Teck Kang
the side effects of glucocorticoids, the dog was treated initially once daily with oral azathioprine (2 mg/kg; Immuthera Tab., Celltrion Pharm Inc., Cheongju, South Korea), modified cyclosporine (7 mg/kg; Cipol-N, Chong Kun Dang Pharm. Corp., Seoul
A simple, specific, and precise high-performance thin-layer chromatographic (HPTLC) method for the analysis of azathioprine, both as a bulk drug and in formulation, was developed and validated. The method employed TLC (thin-layer chromatographic) aluminum plates precoated with silica gel 60 F254 as the stationary phase. The solvent system consisted of methanol-toluene-25% ammonia (7:3:0.1 v/v). This system was found to give compact bands for azathioprine (RF 0.63 ± 0.05). Densitometric analysis of azathioprine was carried out in the absorbance mode at 285 nm. Linear regression analysis data for the calibration spots showed good relationship with regression coefficient r2 = 0.9908 in the range of 20–120 ng/band. The limits of detection and quantification were 6 and 20 ng/band, respectively. The relative standard deviation for instrumental precision, method precision, intra-assay precision, and intermediate precision was <2%. The proposed method was found to be simple, precise, accurate, and reproducible for the estimation of azathioprine in pure drugs and its formulations.
Authors:Petra Anna Golovics, Péter László Lakatos, Gyula Dávid, Tünde Pandur, Zsuzsanna Erdélyi, Ágnes Horváth, Gábor Mester, Mihály Balogh, István Szipocs, Csaba Molnár, Erzsébet Komáromi, Barbara Dorottya Lovász, Miklós Szathmári, Lajos S. Kiss and László Lakatos
Szamosi, T., Banai, J., Lakatos, L., et al.: Early azathioprine/biological therapy is associated with decreased risk for first surgery and delays time to surgery but not reoperation in both smokers and non-smokers with Crohn’s disease, while smoking
Sandborn, W. J., Sutherland, L., Pearson, D. és mtsai:
Azathioprine or 6-mercaptopurine for inducing remission of Crohn’s disease. Cochrane Library,
John Wiley & Sons, Ltd., Chichester, UK, 2000.
Authors:Lajos Sándor Kiss, Tamás Szamosi, Tamás Molnár, Pál Miheller, László Lakatos, Áron Vincze, Károly Palatka, Zsolt Bartha, Beáta Gasztonyi, Ágnes Salamon, Gábor Horváth, Gábor Tamás Tóth, Klaudia Farkas, János Banai, Zsolt Tulassay, Ferenc Nagy, Mária Szenes, Gábor Veres, Barbara Dorottya Lovász, Zsuzsanna Végh, Petra Anna Golovics, Miklós Szathmári, Mária Papp and Péter László Lakatos
: Infliximab, azathioprine, or combination therapy for Crohn’s disease. N. Engl. J. Med., 2010, 362 , 1383–1395.
Infliximab, azathioprine, or combination therapy for Crohn
Ardizzone, S., Maconi, G., Sampietro, G. M. és mtsai:
Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn’s disease. Gastroenterology, 2004,
Sampietro G. M