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Orvosi Hetilap
Authors: Mária Papp, Anikó Farkas, Miklós Udvardy, and István Tornai

Borzio, M., Salerno, F., Piantoni, L. és mtsai: Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study. Dig. Liver Dis., 2001, 33 , 41

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Interventional Medicine and Applied Science
Authors: Kamal Dua, Venkata Ramana Malipeddi, Jyotsna Madan, Gaurav Gupta, Srikumar Chakravarthi, Rajendra Awasthi, Irene Satiko Kikuchi, and Terezinha De Jesus Andreoli Pinto

bacterial infections and burn wounds in alone [9, 10] as well as in combination with Curcuma longa [11] in various topical dosage forms like ointments, gels, creams [9, 11] , and transdermal plasters [10] . Keeping these facts in mind, we have

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this comprehensive literature survey, we summarize recently investigated antibacterial and immune-modulatory effects of butyrate with a focus on its potential to serve as an antibiotic-independent strategy in the combat of bacterial infections. Methods

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Journal of Radioanalytical and Nuclear Chemistry
Authors: F. Yurt Lambrecht, O. Yilmaz, P. Unak, B. Seyitoglu, K. Durkan, S. Yolcular, and H. Baskin

Abstract  

The aim of this study was to evaluate 99mTc labeled human β-defensin-1 (HBD-1) for discrimination between bacterial infection and sterile inflammation. For this purpose, HBD-1 was radiolabeled with 99mTc and its in vivo distribution was evaluated in inflamed rats with Staphylococcus aureus (S. aureus) and sterile inflamed rats with turpentine oil. After injection into inflamed and sterile inflamed rats, 99mTc-HBD-1 was rapidly removed from the circulation via the kidneys. Binding of 99mTc-HBD-1 to inflamed muscle (T/NT = 20 at 120 min) was two times higher than binding to sterile inflamed muscle (T/NT = 10 at 120 min) of rats. It was demonstrated that 99mTc-HBD-1 can be used to detect S. aureus inflammation in rats. However, the radiolabeled antimicrobial peptide showed only poor uptake in sterile inflammation with turpentine oil in rats. As a result, 99mTc-HBD-1 can be useful for detection of bacterial inflammation.

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Orvosi Hetilap
Authors: Balázs Nemes, Fanni Gelley, Eszter Dabasi, György Gámán, Imre Fehérvári, Dénes Görög, László Kóbori, János Fazakas, Eszter Vitális, Attila Doros, Zsuzsanna Gálffy, and Zoltán Máthé

–474. 17 Zhong, L., Men, T. Y, Li, H., et al.: Multidrug-resistant gram-negative bacterial infections after liver transplantation. Spectrum and risk factors. J. Infect., 2012, 64 (3), 299

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]. Previous reports documented health-beneficial effects of vitamins in general [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. Among these, vitamin D has been shown to alleviate several morbidities, including bacterial infections caused by Mycobacterium

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In this review synonymous definitions of reactive arthritis are discussed first. Major clinical symptoms, their infectious etiology and epidemiology define post-dysenteric and post-venereal forms of reactive arthritis. Classical (smear, culture, biochemistry, antigen detection) and molecular (DNA and RNA detections) techniques are used in the routine microbial diagnosis that is retrospective in the majority of cases. In the pathomechanism of this disorder, HLA-B27 antigen positivity of patients is a frequent risk factor. Molecular mimicry between microbial and self-antigens, abnormal antigen presentation leading to incomplete CD8+ T lymphocyte activation might contribute to the persistence of microbial antigens that elicit clinical symptoms. Treatment is rarely successful with antimicrobial chemotherapy.

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In a recent trial we have assessed fractional exhaled nitric oxide (FENO) in a cohort of patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD). In the current study we have retrospectively investigated the frequency of severe hospitalization-associated exacerbations in the same cohort over 3 years after the initial FENO measurement. A total of 58 COPD patients were enrolled and allocated either into the low (< 27 ppb) or the high (≥ 27 ppb) FENO group depending on their FENO level at exacerbation. Beside the annual rate of exacerbations, sputum culture results and the frequency of antibiotic treatments were also analyzed during the follow-up. Both the number of exacerbations per patient-year and the hospitalization days due to exacerbations were significantly increased in patients from the low FENO group compared to those from the high FENO group. Sputum samples derived from patients in the low FENO group were more frequently indicative of a bacterial infection compared to those obtained from the other subgroup. Also, the frequency of antibiotic treatments was significantly increased in subjects from the low FENO group. Results of this pilot study suggest that COPD patients have diverse risks for future exacerbations depending on their FENO levels at exacerbation.

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]. Since the discovery of the penicillin by Alexander Fleming in 1928 [ 1 ], a multitude of antibiotic substances have been discovered and added to mankind’s armory against bacterial infections. But almost a hundred years later, we still lack potent

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European Journal of Microbiology and Immunology
Authors: Jennifer zur Bruegge, Christina Backes, Greta Gölz, Georg Hemmrich-Stanisak, Lydia Scharek-Tedin, Andre Franke, Thomas Alter, Ralf Einspanier, Andreas Keller, and Soroush Sharbati

. Eulalio A , Schulte L , Vogel J : The mammalian microRNA response to bacterial infections . RNA Biol 9 , 742 – 750 ( 2012 ) 4. Staedel

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