Authors:Kamal Dua, Venkata Ramana Malipeddi, Jyotsna Madan, Gaurav Gupta, Srikumar Chakravarthi, Rajendra Awasthi, Irene Satiko Kikuchi, and Terezinha De Jesus Andreoli Pinto
bacterialinfections and burn wounds in alone [9, 10] as well as in combination with Curcuma longa  in various topical dosage forms like ointments, gels, creams [9, 11] , and transdermal plasters  .
Keeping these facts in mind, we have
Authors:Ke Du, Stefan Bereswill, and Markus M. Heimesaat
this comprehensive literature survey, we summarize recently investigated antibacterial and immune-modulatory effects of butyrate with a focus on its potential to serve as an antibiotic-independent strategy in the combat of bacterialinfections. Methods
Authors:F. Yurt Lambrecht, O. Yilmaz, P. Unak, B. Seyitoglu, K. Durkan, S. Yolcular, and H. Baskin
The aim of this study was to evaluate 99mTc labeled human β-defensin-1 (HBD-1) for discrimination between bacterial infection and sterile inflammation. For this purpose,
HBD-1 was radiolabeled with 99mTc and its in vivo distribution was evaluated in inflamed rats with Staphylococcus aureus (S. aureus) and sterile inflamed rats with turpentine oil. After injection into inflamed and sterile inflamed rats, 99mTc-HBD-1 was rapidly removed from the circulation via the kidneys. Binding of 99mTc-HBD-1 to inflamed muscle (T/NT = 20 at 120 min) was two times higher than binding to sterile inflamed muscle (T/NT = 10
at 120 min) of rats. It was demonstrated that 99mTc-HBD-1 can be used to detect S. aureus inflammation in rats. However, the radiolabeled antimicrobial peptide showed only poor uptake in sterile inflammation with
turpentine oil in rats. As a result, 99mTc-HBD-1 can be useful for detection of bacterial inflammation.
Authors:Ainoosh Golpour, Stefan Bereswill, and Markus M. Heimesaat
Previous reports documented health-beneficial effects of vitamins in general [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. Among these, vitamin D has been shown to alleviate several morbidities, including bacterialinfections caused by Mycobacterium
In this review synonymous definitions of reactive arthritis are discussed first. Major clinical symptoms, their infectious etiology and epidemiology define post-dysenteric and post-venereal forms of reactive arthritis. Classical (smear, culture, biochemistry, antigen detection) and molecular (DNA and RNA detections) techniques are used in the routine microbial diagnosis that is retrospective in the majority of cases. In the pathomechanism of this disorder, HLA-B27 antigen positivity of patients is a frequent risk factor. Molecular mimicry between microbial and self-antigens, abnormal antigen presentation leading to incomplete CD8+ T lymphocyte activation might contribute to the persistence of microbial antigens that elicit clinical symptoms. Treatment is rarely successful with antimicrobial chemotherapy.
In a recent trial we have assessed fractional exhaled nitric oxide (FENO) in a cohort of patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD). In the current study we have retrospectively investigated the frequency of severe hospitalization-associated exacerbations in the same cohort over 3 years after the initial FENO measurement. A total of 58 COPD patients were enrolled and allocated either into the low (< 27 ppb) or the high (≥ 27 ppb) FENO group depending on their FENO level at exacerbation. Beside the annual rate of exacerbations, sputum culture results and the frequency of antibiotic treatments were also analyzed during the follow-up. Both the number of exacerbations per patient-year and the hospitalization days due to exacerbations were significantly increased in patients from the low FENO group compared to those from the high FENO group. Sputum samples derived from patients in the low FENO group were more frequently indicative of a bacterial infection compared to those obtained from the other subgroup. Also, the frequency of antibiotic treatments was significantly increased in subjects from the low FENO group. Results of this pilot study suggest that COPD patients have diverse risks for future exacerbations depending on their FENO levels at exacerbation.
Authors:Samuel Füchtbauer, Soraya Mousavi, Stefan Bereswill, and Markus M. Heimesaat
]. Since the discovery of the penicillin by Alexander Fleming in 1928 [ 1 ], a multitude of antibiotic substances have been discovered and added to mankind’s armory against bacterialinfections. But almost a hundred years later, we still lack potent