The formation of benzynes derivatives from ortho-trimethylsilyl triflates using tetra-n-butylammonium fluoride (TBAF) as the benzyne-forming trigger was achieved in a straightforward flow reactor at room temperature. These benzynes were immediately trapped in Diels—Alder reactions to deliver the desired cycloadducts.
carbide microreactor” S. G. Newman, L. Gu, C. Lesniak, G. Victor, F. Meschke, L. Abahmane, K. F. Jensen* Green Chemistry 2014 , 16 , 176–180
“Three-component coupling based on flash chemistry. Carbolithiation of benzyne with