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are a common component of our daily lives and usually contain preservatives that are added to prevent microbial growth [ 2 ]. Bithionol has been used as preservatives in cosmetics production, but it has been banned by the United States (US) Food and

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The chromatographic behavior of the phenolic drugs niclosamide, hexachlorophene, ibuprofen, pentazocine, ethamivan, bithionol, salicylanilide, caffeic acid, p -coumaric acid, 4-aminosalicylic acid, ferulic acid, and methyldopa has been investigated on RP8F 254s and RP18F 254s TLC plates with methanol-water mixtures in different volume proportions as mobile phases. Linear relationships were obtained between the R M values of the drugs and the volume fraction of methanol in the mobile phase. Retention values, R M , were extrapolated to zero methanol content and the lipophilicity values R MW(RP8) and R MW(RP18) obtained were compared both with measured partition coefficients (log P exp ) and with partition coefficients (AlogPs, IAlogP, AB/logP, COSMOFFrag, miLogP, KOWWIN, and xlogP) calculated using seven different software products. Comparison of the calculated partition coefficients revealed IAlogP, KOWWIN, miLogP, and

\documentclass{aastex} \usepackage{amsbsy} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{bm} \usepackage{mathrsfs} \usepackage{pifont} \usepackage{stmaryrd} \usepackage{textcomp} \usepackage{upgreek} \usepackage{portland,xspace} \usepackage{amsmath,amsxtra} \pagestyle{empty} \DeclareMathSizes{10}{9}{7}{6} \begin{document} $$\overline {\log P}$$ \end{document}
(where is the average of all the theoretical partition coefficients) usually correlate best with chromatographic lipophilicity R MW . The results indicate that chromatographic lipophilicity R MW can be used as a measure of the lipophilicity of the phenolic drugs investigated.

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