Authors:V. Kovács, Zs. Fajcsák, A. Gábor and É. Martos
.G., Striegel-Moore, R.H., Franko, D.L., Albertson, A.M. & Crockett, S.J.
(2005): The relationship of breakfast and cereal consumption to nutrient intake and bodymassindex: the National Heart, Lung, and Blood Institute Growth and Health Study.
J. Am. Diet
Authors:Trayana Djarova, D. Bardarev, D. Boyanov, R. Kaneva and P. Atanasov
Aim: To analyse and compare the ACE (angiotensin-converting enzyme), ACTN3 (actinin-3) and AMPD1 (adenosine monophosphate deaminase 1) genetic variants, oxygen uptake (VO2max), heart rate (HR), blood pressure (BP) and body mass index (BMI) of elite high altitude mountaineers and average athletes. Methods: Elite Bulgarian alpinists (n = 5) and control group of athletes (n = 72) were recruited. VO2max was measured using a treadmill graded protocol. HR, BP and BMI were recorded. Genotyping was done by polymerase chain reaction (PCR) amplification followed by agarose gel electrophoresis. Chi2-test and Fisher’s exact test were used for statistical analysis. Results: Alpinists showed significantly higher frequencies of 60% ACE I allele (p = 0.002), 50% ACTN3 X allele (p = 0.032) and 30% AMPD1 T allele (p = 0.003) compared to controls — 39%, 36%, 13%, respectively. ACE ID genotype prevalence and null DD genotype were observed in mountaineers. Higher absolute VO2max, but no differences in VO2max ml kg−1 min−1, HR, oxygen pulse, blood pressure and BMI were found. Conclusions: The ID genotype and higher frequencies of ACE I allele could contribute to successful high altitude ascents in mountaineers. The genetic make-up of the two mountaineers who made the summit of Mt Everest was distinctive, revealing ACE ID genotype, mutant ACTN3 XX and AMPD1 TT genotypes.