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Abstract  

Samarium-153-EDTMP (ethylene diamine tetramethylene phosphonate), for its promising biological properties, has been proved as a palliating therapeutic agent for boné cancer in human beings. In this article, we present the results on synthesis and structure analysis of Samarium-153-EDTMP. In a basic medium,153Sm-EDTMP can be readily prepared with a complexing yield not less than 98%, and it is confirmed that the ratio of the ligand to Sm is 11, and the charge of153Sm-EDTMP is negative two.

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Orvosi Hetilap
Authors: Tamás Perlaky, János Kiss, Krisztián Szalay, Moghaddam Amin Maysam, Péter Ágoston, and Miklós Szendrői

–171. 6 Poffyn B, Sys G, Mulliez A, et al. Extracorporeally irradiated autografts for the treatment of bone tumours: tips and tricks. Int Orthop (SICOT). 2011; 35: 889

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Abstract  

A complex of methods for the in-vitro and in-vivo bone analysis was developed. Among the in-vitro methods are: INAA with reactor and 14 MeV neutrons; IGAA with 25 MeV linear accelerator; XRF with55Fe,109Cd,241Am radionuclide sources. Twenty-five elements could be analyzed by it: N, F, Na, Mg, P, Cl, K, Ca, Sc, Cr, Mn, Fe, Co, Zn, Se, Br, Rb, Sr, Ag, Sb, Cs, Ba, Tb, Hg, and Pb. Among the in-vivo methods are: INAA of band, foot and spine Ca and limb bone tumour Ca, Na and Cl with238Pu–Be neutron sources; IGAA of N and P in limb bone tumours; XRF of tooth Ca, Zn, Sr and Pb with109Cs radionuclide sources. The methods developed were used both in clinical and experimental medicine for studying the healthy human and animal bone with different diseases and environmental influence.

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Abstract  

A facility developed for the in-vivo neutron activation analysis (IVNAA) of calcium in some parts of tubular limb bones, in the hand, foot and spine is described. The48Ca(n, )49Ca reaction is used, the gamma-rays of49Ca (E=3.08 MeV, T1/2=8.8 min) are measured. The irradiation is carried out with five of ten238Pu–Be neutron sources with a source stength of 5·107 n s–1 each arranged in a bath filled with water. NaI(T1) detectors (from 2 to 4 in number) of 150×100 mm size supplied with lead and shadow shielding are used in the counting unit. The construction of the facility started in 1972 and has been in operation since 1974. It has been used for the examination of patients suffering from limb bone tumors, of children with rickets-like and similar diseases and for studies in space medicine.

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Abstract  

Blood plasma modeling has proved effective in the evaluation of clinical observations recorded for baboon and rat tests with 153Sm- ethylenediaminetetraphosphonic acid (EDTMP) as well as for 166Ho-EDTMP. In the search for a cure for metastatic bone cancer, 117mSn with its conversion electrons of discrete energies shows low bone marrow toxicity, providing the opportunity to increase the administered dose. Selective accumulation in lesions would capitalize on this advantage. The 10-30 kDa fraction of the water-soluble polymer polyethyleneimine, functionalized with methylene phosphonate groups (PEI-MP) and labeled with 99mTc, has shown selective uptake into bone tumours. This paper relates the speciation of Sn(II)-PEI-MP and other known 117mSn(II) containing bone-seeking radiopharmaceuticals in blood plasma. Apparent formation constants for the complexation of SnII with PEI-MP, DTPA, HEDP and other important blood plasma ligands were measured potentiometrically or estimated by linear free energy relationships (LFER). These data were added to the ECCLES database in order to construct a blood plasma model for SnII. From this model it is predicted that SnII will remain bound to the polymer (PEI-MP) in blood plasma and therefore, have only slight reticuloendothelial uptake. Preliminary primate studies indeed proved that the complex between SnII and PEI-MP remains intact in blood plasma, which is consistent with the observation for PEI-MP labeled with 99mTc. From these data, it was also possible to explain in retrospect the lower bone uptake, the slow blood clearance and the liver uptake of the agents 117mSn(II) DTPA and 117mSn(II) HEDP agents as reported in the literature.

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Calorimetric methods are becoming important analytical tools in several areas of biochemical and biological research. In this work, a flow microcalorimetric method has been applied to the determination of dihydrofolate reductase (DHFR) activities in rat and human malignant tissue homogenates. In contrast to other commonly used DHFR analytical assays, the sensitivity of flow microcalorimetry allows direct measurements of this enzyme in crude tissue preparations. Our experimental data from rat tissue homogenates show that liver has the highest level of enzyme activity, while lung and brain have lower amounts of DHFR activity. The liver enzyme has a higher activity atpH 4.5, but the optimumpH for the lung and brain enzymes is 6.8. The substrate/cofactor molar ratio which gives the highest levels of DHFR activity is 1/1.5 for the liver and lung enzymes and 1/2.5 for brain DHFR. The DHFR in these rat tissue homogenates is activated by KCl or NaCl: in the presence of these salts (0.6M), the values of enzyme activity are 1.5–3 times higher than in their absence. Using flow microcalorimetry, very low levels of DHFR activity were also measured in human bone tumour homogenates, demonstrating the potential of the technique in the analysis of this enzyme in malignant tissues.

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Magyar Sebészet
Authors: Ákos Kocsis, László Agócs, Szilárd Kostic, Klára Török, Miklós Molnár, Bernadett Lévay, Ferenc Tóth, Pál Vadász, and Ferenc Rényi-Vámos

Absztrakt

Bevezetés: A primer malignus csontdaganatok kb. 30%-a chondrosarcoma, leginkább az elülső mellkasfalon jelentkeznek. Azoknak a betegeknek, akik megfelelő sebészi kezelést kapnak, 97%-os a 10 éves túlélési rátájuk. Ezenfelül fontos a terhelhetőség és a légzési funkció megőrzése, nem utolsósorban pedig az esztétikai eredmény. Beteg: A szerzők egy 44 éves férfi beteg esetét ismertetik, aki sportmasszőrként dolgozott, és a manubrium sterni Grade II chondrosarcomája miatt került műtétre. A beavatkozás során a sternum érintett része szélesen az épben kimetszésre került, a helyreállítás során a Dual Mesht bal oldali pectoralis major lebennyel fedték, valamint egyedi megoldásként a semitendinosus és -gracilis izmok inát felhasználva fixáltak két claviculát egymáshoz, ezáltal nagyfokú stabilitást adva a mellkasfalnak, és -visszaadva a felső végtag, illetve a vállöv terhelhetőségét. Eredmény: Eseménytelen posztoperatív szak után a beteg hamar felépült, és gyorsan visszatérhetett korábbi, a vállövet jelentősen igénybe vevő munkájához. Következtetés: A szerzők nem találtak hasonló műtéti eljárást az irodalomban, és ajánlják alkalmazását hasonló esetekben.

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., 2007, 57 (1), 30–42. Kelley, S. P., Ashford, R. U., Rao, A. S., et al.: Primary bone tumours of the spine: a 42-year survey from the Leeds Regional Bone Tumour Registry. Eur. Spine J., 2007, 16 (3), 405

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2007 Stacy, G. S., Mahal, R. S. and Peabody, T. D. (2006): Staging of bone tumours: a review with illustrative examples. Am. J. Roentgenol. 186 , 967

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Orvosi Hetilap
Authors: Attila Szatmári, Balázs Benedek, Tamás Perlaky, Krisztián Szalay, Imre Sallai, Gábor Skaliczki, Miklós Szendrői, and Imre Antal

, Søjbjerg JO, et al. Reverse shoulder replacement after resection of the proximal humerus for bone tumours. Bone Joint J. 2013; 95: 1551–1555. 10 Guven MF, Aslan L, Botanlioglu H

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