Gao J, Lin Y, Qiu C, Liu Y, Ma Y, Gan J: Relationship between HLAA-DQA1, — DQB1 genes polymorphism and susceptibility to bronchialasthma among Northern Hans (in Chinese). Zhonghua Yi Xue Za Zhi 2002, 379–383 (2002
The aim of the paper is to give an overview of the knowledge on asthma through the history of mankind. The text begins with ancient China and it is finished with the medicine of Middle Age. During this time, a lot of theories came and this appeared about the etiology and therapy of the disease. The paper is giving a short description of the changing medical views during this very long period including China, Egypt Greco-roman period, Mesopotamia, the Hebrews, the physicians of India, the pre-Columbian medicine in the America and the Arabic world, and partly the European medicine of the Middle Ages.
The aim of the paper is to give an overview of the history of knowledge on asthma from the Renaissance till the beginning of the 20 th century. During this period the clinical picture of bronchial asthma and some etiological factors - like familiarity of the disease, the role of the pollen, psychological factors - were cleared. The disease was relatively rare in these periods - the epidemiological explosion came only in the second half of the 20 th century. Data on pediatric asthma, before all in Hungary are demonstrated mostly based on the works of Schoepf and Bókai senior in the first half of the 19 th century.
Authors:J. Korpas, M. Vrabec, J. Sadlonova, D. Salat and L. A. Debreczeni
It is well known that the frequency distribution of cough sound varies in different pathological conditions. Its identification could have diagnostic value. In this study the cough sound frequency in adults (n=20, 51.7±11 yrs), children (n=21, 11.8±0.4 yrs) asthmatics and healthy volunteers (n=25, 21 yrs) was explored. All patients were suffering from bronchial asthma. They were on a stable therapeutic regime and in a quiet status. Voluntary cough sound was recorded by a microphone and a tape recorder and digitally processed. Overlapping technique and Fast Fourier Transform were used to estimate the sound spectra. The records were smoothed by the method of Pascal triangle. They demonstrate the mean values of cough sound spectra. The registered pseudo three-dimensional plots of cough sound frequency (1 K spectra as function in time) of adults showed that the intensity of frequencies increased from 100 to 900 Hz in 3-4 waves. These frequencies afterwards decreased and between 1 to 2 kHz a smaller elevation was present. The spectra of children resembled to the spectrum of adults but had a smoother course. The spectra of asthmatics had some specificity and differed from the spectrum of healthy volunteers.