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Agyi myeloma képét utánzó toxoplasmosis
Toxoplasmosis masquerading as cerebral myeloma
, Ho P J . Prolonged immunosuppression in relapsed, refractory multiple myeloma leading to cerebral toxoplasmosis and progressive multifocal leukoencephalopathy . Clin Lymphoma Myeloma Leuk
The virulence and pathogenicity of various types of Toxoplasma gondii differ considerably in mice. Recent studies have claimed that similar phenomenon was observed in humans, but no relevant studies have been performed to validate this finding. In addition, reports showing association between a given T. gondii type and outcomes of human infection yielded conflicting results. To provide a more precise estimation of the association and a more reliable conclusion on this subject, we performed this meta-analysis. Relevant literatures were identified in multiple databases and selected based on strict screening. T. gondii-type proportions among different severities of infection were calculated and compared using Fisher’s exact test. Pooled odds ratios (OR) were calculated. Our results showed that the difference among T. gondii-type proportions was significant (p < 0.0001). In addition, significant associations were detected between Type I strains infection and congenital toxoplasmosis (OR: 1.91, p = 0.0009), Type III strains infection and pulmonary toxoplasmosis (OR: 5.15, p = 0.04). In our subgroup analysis, Type I strains were significantly associated with cerebral toxoplasmosis in offspring (OR: 1.81, p = 0.02). This result indicated that different types of T. gondii exhibited different virulence and caused different outcomes in humans.
. gondii -induced neuroinflammation [ 16 ], and the immunoproteasome subunits LMP2, LMP7 and MECL-1 are crucial along the induction of cerebral toxoplasmosis [ 17 ]. Infection with T. gondii has been associated with schizophrenia [ 18 , 19 ], mixed
) 25. Falangola MF , Petito CK : Choroid plexus infection in cerebral toxoplasmosis in AIDS patients . Neurology 43 , 2035 – 2040 ( 1993
T.A. Wynn A. Sher 1993 Acute cerebral toxoplasmosis is induced by in vivo neutralization of tnf-alpha and correlates with the down
. Brain Behav Immun 43 , 192 – 197 ( 2015 ) 15. Prandota J : Recurrent headache as the main symptom of acquired cerebral
infection in cerebral toxoplasmosis in AIDS patients Neurology 43 2035 – 2040 . 53. S.H. DeMent
cerebral toxoplasmosis . J Immunol 194 , 3223 – 3235 ( 2015 ) 58. Dunay IR , Fuchs A , Sibley LD : Inflammatory monocytes but not neutrophils
): Cerebral toxoplasmosis in striped dolphins ( Stenella coeruleoalba ) stranded along the Ligurian Sea coast of Italy . Vet. Pathol. 47 , 245 – 253 . 10.1177/0300985809358036 Díaz-Delgado , J. , Groch , K. R. , Sierra , E. , Sacchini , S. , Zucca
Wolf , SA Jeron , A Mack , M Heimesaat , MM , Ly6C(high) monocytes control cerebral toxoplasmosis . J Immunol. 2015 ; 194 : 3223 – 35 . 10
