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Agyi myeloma képét utánzó toxoplasmosis

Toxoplasmosis masquerading as cerebral myeloma

Hematológia–Transzfuziológia
Authors:
Eszter Nagy
,
Andrea Ceglédi
,
Bálint Gergely Szabó
,
Botond Lakatos
,
Viktória Kiss Anita
,
András Kozma
,
Attila Balogh
,
Hajnalka Rajnai
,
Péter Reményi
, and
Gábor Mikala

, Ho P J . Prolonged immunosuppression in relapsed, refractory multiple myeloma leading to cerebral toxoplasmosis and progressive multifocal leukoencephalopathy . Clin Lymphoma Myeloma Leuk

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The virulence and pathogenicity of various types of Toxoplasma gondii differ considerably in mice. Recent studies have claimed that similar phenomenon was observed in humans, but no relevant studies have been performed to validate this finding. In addition, reports showing association between a given T. gondii type and outcomes of human infection yielded conflicting results. To provide a more precise estimation of the association and a more reliable conclusion on this subject, we performed this meta-analysis. Relevant literatures were identified in multiple databases and selected based on strict screening. T. gondii-type proportions among different severities of infection were calculated and compared using Fisher’s exact test. Pooled odds ratios (OR) were calculated. Our results showed that the difference among T. gondii-type proportions was significant (p < 0.0001). In addition, significant associations were detected between Type I strains infection and congenital toxoplasmosis (OR: 1.91, p = 0.0009), Type III strains infection and pulmonary toxoplasmosis (OR: 5.15, p = 0.04). In our subgroup analysis, Type I strains were significantly associated with cerebral toxoplasmosis in offspring (OR: 1.81, p = 0.02). This result indicated that different types of T. gondii exhibited different virulence and caused different outcomes in humans.

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European Journal of Microbiology and Immunology
Authors:
Laura Alejandra Mendoza-Larios
,
Fernando García-Dolores
,
Luis Francisco Sánchez-Anguiano
,
Elizabeth Irasema Antuna-Salcido
,
Jesús Hernández-Tinoco
,
Adriana Rocha-Salais
,
Marcela Araceli Segoviano-Mendoza
,
Antonio Sifuentes-Álvarez
, and
Cosme Alvarado-Esquivel

. gondii -induced neuroinflammation [ 16 ], and the immunoproteasome subunits LMP2, LMP7 and MECL-1 are crucial along the induction of cerebral toxoplasmosis [ 17 ]. Infection with T. gondii has been associated with schizophrenia [ 18 , 19 ], mixed

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European Journal of Microbiology and Immunology
Authors:
Cosme Alvarado-Esquivel
,
Luis Francisco Sánchez-Anguiano
,
Alejandra Mendoza-Larios
,
Jesús Hernández-Tinoco
,
José Francisco Pérez-Ochoa
,
Elizabeth Irasema Antuna-Salcido
,
Elizabeth Rábago-Sánchez
, and
Oliver Liesenfeld

) 25. Falangola MF , Petito CK : Choroid plexus infection in cerebral toxoplasmosis in AIDS patients . Neurology 43 , 2035 – 2040 ( 1993

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T.A. Wynn A. Sher 1993 Acute cerebral toxoplasmosis is induced by in vivo neutralization of tnf-alpha and correlates with the down

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European Journal of Microbiology and Immunology
Authors:
Cosme Alvarado-Esquivel
,
Luis Francisco Sánchez-Anguiano
,
Jesús Hernández-Tinoco
,
Alma Rosa Pérez-Álamos
,
Yazmin del Rosario Rico-Almochantaf
,
Sergio Estrada-Martínez
,
Raquel Vaquera-Enriquez
,
Arturo Díaz-Herrera
,
Agar Ramos-Nevarez
,
Ada Agustina Sandoval-Carrillo
,
José Manuel Salas-Pacheco
,
Sandra Margarita Cerrillo-Soto
,
Elizabeth Irasema Antuna-Salcido
,
Oliver Liesenfeld
, and
Carlos Alberto Guido-Arreola

. Brain Behav Immun 43 , 192 – 197 ( 2015 ) 15. Prandota J : Recurrent headache as the main symptom of acquired cerebral

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infection in cerebral toxoplasmosis in AIDS patients Neurology 43 2035 – 2040 . 53. S.H. DeMent

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European Journal of Microbiology and Immunology
Authors:
Ting Fu
,
Eva B. Znalesniak
,
Thomas Kalinski
,
Luisa Möhle
,
Aindrila Biswas
,
Franz Salm
,
Ildiko Rita Dunay
, and
Werner Hoffmann

cerebral toxoplasmosis . J Immunol 194 , 3223 – 3235 ( 2015 ) 58. Dunay IR , Fuchs A , Sibley LD : Inflammatory monocytes but not neutrophils

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Acta Veterinaria Hungarica
Authors:
Federica Giorda
,
Giovanni Di Guardo
,
Katia Varello
,
Alessandra Pautasso
,
Eva Sierra
,
Maria Domenica Pintore
,
Carla Grattarola
,
Erika Molica Colella
,
Enrica Berio
,
Maria Goria
,
Elena Bozzetta
,
Cristina Casalone
, and
Barbara Iulini

): Cerebral toxoplasmosis in striped dolphins ( Stenella coeruleoalba ) stranded along the Ligurian Sea coast of Italy . Vet. Pathol. 47 , 245 – 253 . 10.1177/0300985809358036 Díaz-Delgado , J. , Groch , K. R. , Sierra , E. , Sacchini , S. , Zucca

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Wolf , SA Jeron , A Mack , M Heimesaat , MM , Ly6C(high) monocytes control cerebral toxoplasmosis . J Immunol. 2015 ; 194 : 3223 – 35 . 10

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