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. , Santarpia , C. , Grieco , D. ( 2007 ) Oxidative stress overrides the spindle checkpoint . Cell Cycle 6 , 576 – 579 . 4. Draviam , V. M. , Xie , S. , Sorger , P. K

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–579. 3 Ribas A. Tumor immunotherapy directed at PD-1. N Engl J Med. 2012; 366: 2517–2519. 4 Postow MA, Callahan MK, Wolchok JD. Immune checkpoint blockade in cancer

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clinical trial. Clin. Cancer Res., 2010, 16 (10), 2861–2871. 14 Postow, M. A., Callahan, M. K., Wolchok, J. D.: Immune checkpoint blockade in cancer therapy. J. Clin

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Orvosi Hetilap
Authors: Csilla Oláh, Melinda Váradi, Orsolya Horváth, Péter Nyirády, and Tibor Szarvas

Frankel AE, Coughlin LA, Kim J, et al. Metagenomic shotgun sequencing and unbiased metabolomic profiling identify specific human gut microbiota and metabolites associated with immune checkpoint therapy efficacy in

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Acta Alimentaria
Authors: S. Vannini, R. Pagiotti, M. Acito, S. Levorato, L. Dominici, C. Fatigoni, V. Gianfredi, M. Moretti, and M. Villarini

neoplastic DNA replication: evidence for failure in decision-making at the mitotic cell cycle checkpoint G(1)/S . Exp. Hematol. , 36 ( 11 ), 1403 – 1416 . Punt

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, hypersensitivity reactions, and different classes of immunoglobulins. Biologics, 2015, 9, 7–12. 24 Armand, P.: Immune checkpoint blockade in hematologic malignancies

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design experimentally; responses polynomial equations and model validation was done through numerical checkpoint prediction methodology to optimization. Results and Discussion During physicochemical evaluation

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. 2019; 18(Suppl): e2106–e2107. 20 Kim J, Kwiatkowski D, McConkey DJ, et al. The Cancer Genome Atlas expression subtypes stratify response to checkpoint inhibition in advanced

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Orvosi Hetilap
Authors: Bálint Egyed, Gábor Kovács, Nóra Kutszegi, Andrea Rzepiel, Judit Csányiné Sági, Dániel János Erdélyi, Judit Müller, and Ágnes Félné Semsei

–4389. 53 Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12: 252–264. 54 Chan TS, Sim JP, Kwong YL. Low-dose nivolumab-induced responses in

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In the 20th century more than 60000 torsion balance measurements were made in Hungary. At present efforts are made to rescue the historical torsion balance data; today 24544 torsion balance measurements are available for further processing in computer database. Previously only the horizontal gradients of gravity were used by geophysicists, but there is a good possibility in geodesy to interpolate deflections of the vertical, and to compute geoid heights from curvature gradients of gravity. First the theory of the interpolation method is discussed, than results of test computations are presented. We have selected a test area where all kinds of torsion balance measurements are available at 249 points. There were 3 astrogeodetic points providing initial data for the interpolation, and 10 checkpoints for controlling the results. The size of our test area is about 750 km2 and the average site distance of torsion balance data is 1.5-2 km. The standard deviations of geoid height and deflection of the vertical differences at checkpoints were about ±1-3 cm, and ± 0.6'' respectively; which confirm that torsion balance measurements give possibility to compute very precise deflections of the vertical and local geoid heights at least for flat areas.

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