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. 7. P.B. Berger 2000 Results of the ticlid or plavix post-stents (TOPPS) trial: do they justify the switch from ticlopidine to clopidogrel after coronary stent placement

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Orvosi Hetilap
Authors: László Szapáry, Katalin Koltai, Antal Tibold, Andrea Fehér, Gábor Harang, Gabriella Pusch, and Gergely Fehér

., Feher, A., Pusch, G., et al.: Clinical importance of aspirin and clopidogrel resistance. World J. Cardiol., 2010, 2 (7), 171–186. Sofi, F., Marcucci, R., Gori, A. M., et al.: Clopidogrel non-responsiveness and

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Summary

A simple and rapid TLC method using β-cyclodextrin as a chiral mobile phase additive (CMPA) was developed for direct separation of S-clopidogrel and its impurity R-clopidogrel. The influence of different factors (stationary phases, organic modifiers, chiral selectors and their concentrations in the mobile phase, and optimal saturation time of the chamber) on enantioseparation was studied. The best resolution of clopidogrel enantiomers was achieved on Polygram®cel 300 Ac-10% plates using isopropanol-0.5 mM β-cyclodextrin (6:4, υ/υ) as mobile phase in TLC chamber previously equilibrated with the mobile phase for 20 min. The spots were detected under UV light and using iodine vapours. The method enables rapid separation of clopidogrel enantiomers and can be successfully used in control of stereoselective synthesis of clopidogrel and in control of its purity. Finally, the molecular modelling of the inclusion complexes between the analytes and α-, β-, and γ-cyclodextrin was performed to investigate the mechanism of the enantiorecognition.

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Acta Physiologica Hungarica
Authors: G. Nyírő, G. Inczédy-Farkas, V. Reményi, A. Gál, Zs Pál, and Mária Molnár

Bhatt DL, Topol EJ: Clopidogrel added to aspirin versus aspirin alone in secondary prevention and high-risk primary prevention: Rationale and dosing of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance

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more active and consistent platelet inhibition. However, because of the financial and regulatory reasons, the availability of these drugs is not optimal, thus the earlier generation ADP blocker clopidogrel is still frequently used [ 3 ]. Clopidogrel is

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Summary

A simple, precise, and accurate HPTLC method has been established for simultaneous quantification of aspirin, atorvastatin calcium and clopidogrel bisulphate in the bulk drug and in a capsule dosage form. Chromatographic separation of the drugs was performed on aluminium foil plates precoated with silica gel 60 F254, with toluene-methanol-formic acid 6.5:3.5:0.1 (v/v) as mobile phase. Densitometric evaluation of the separated zones was performed at 254 nm. The three drugs were satisfactorily resolved with R F ± SD values 0.26 ± 0.01, 0.47 ± 0.01, and 0.78 ± 0.01 for aspirin, atorvastatin calcium, and clopidogrel bisulphate, respectively. The method was validated for linearity, specificity, accuracy, precision, and robustness, in accordance with ICH guidelines. Results from recovery studies indicated acceptable recovery of the drugs from the capsule dosage form. The intra-day and inter-day relative standard deviations were in the ranges 0.17–0.73% and 0.46–1.03% for aspirin, 0.36–0.87% and 0.44–0.62% for atorvastatin calcium, and 0.25–0.69% and 0.35–0.94% for clopidogrel bisulphate. The method proved to be a rapid and cost-effective quality-control tool for routine simultaneous analysis of aspirin, atorvastatin calcium, and clopidogrel bisulphate in the bulk drug and in a capsule formulation.

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anticoagulant therapy undergoing coronary stenting. ESC, Hotline III, Munchen, August 28th, 2012. CAPRIE Steering Committee: A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of

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1598 1660 Peters, R. J., Mehta, R. S., Fox, K. A. és mtsai: Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute

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Technology Co. Ltd. (Sichuan, China). Clopidogrel (internal standard, IS) was obtained from the National Institute for the Control of Pharmaceutical and Biological Products (Beijing, China). Methanol was purchased from Sigma (St Louis, MO, USA). Formic acid

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Orvosi Hetilap
Authors: András Jánosi, Péter Ofner, Zoltán Kiss, Levente Kiss, Róbert Gábor Kiss, József Dinnyés, Zoltán Járai, Gergely Nagy, Gábor Veress, and Tamás Ferenci

–479. 21 Boggon R, van Staa TP, Timmis A, et al. Clopidogrel discontinuation after acute coronary syndromes: frequency, predictors and associations with death and myocardial infarction – a hospital registry

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