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Functional role of calcium-activated potassium (KCA) channels on the basal and agonist-elevated arterial tones was investigated in isolated rabbit aorta, porcine and canine coronary arteries as well as in human internal mammary artery. The vascular tones enhanced by contractile agents were increased further by preincubation of these conduit blood vessels with selective (charybdotoxin or iberiotoxin) or non-selective (tetraethylammonium) inhibitors of KCA channels. The basal tone (without an agonist) was increased only in the canine coronary artery. The results indicate a feed-back regulatory role of KCA channels counteracting the vasospasm of conduit arteries.

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Orvosi Hetilap
Authors: Taha El Hadj Othmane, István Kiss, János Nemcsik, Cs. Bertalan Fekete, György Deák, József Egresits, Erzsébet Fodor, K. Zsófia Németh, Tamás Szabó, Miklós Szathmári and András Tislér

: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation, 2006, 113 , 1213–1225. Thom S. M. Anglo-Scandinavian Cardiac Outcomes Trial Investigators. CAFE

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. S., Thom, S. M., et al.: Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation, 2006, 113 (9), 1213

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aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation 113(9), 1213–1225 (2006) Thom S.M. Differential impact of

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Physiology International
Authors: P. L. Latchman, G. Gates, J. Pereira, R. Axtell R, K. Gardner, J. Schlie, Q. Yang, T. Yue, A. Morin-Viall and R. DeMeersman

conduit artery function evaluation (CAFE) study . Circulation 2006 ; 113 : 1213 – 1225 . [39] Zhang DY , Anderson AS . The sympathetic nervous system and heart failure . Cardiol Clin 2014 ; 32 : 33 – 45 . 10.1016/j.ccl.2013.09.010 [40] Zhao

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