Search Results

You are looking at 1 - 10 of 187 items for :

  • "connective tissue" x
  • Refine by Access: All Content x
Clear All

A szerző összefoglalja a kötőszövet szerkezeti felépítését, a struktúra és a funkció meghatározásában döntő építőelemek szakadatlan változását. Érinti a struktúra és funkció egymásra hatását, a nyugalmi és az inflammatio determináns eseményeit. Hangsúlyozza, hogy a kötőszöveti funkciók együttesen részesülnek a szervezet épségét biztosító inflammatoricus történésekben. Jelentős hangsúlyt kap az a tétel, hogy az élő organizmus épségének védelme, a bekövetkezett károsodás lokalizálása, az elhárítás és restitutio ad integrum elérésében a szervezet eszköze az inflammatio, a nem specifikus immunválasz, amelyhez elkülöníthetetlenül társul a specifikus, adaptív immunitás. A folyamatok „székhelye” pedig a kötőszövet. A steril és kórokozó kiváltotta inflammatio igen sok azonosságot mutat, de megfogalmazódnak a különbségek is. Szóba kerülnek a proteoglikánok, ezeknek nagyon élénken tevékenykedő élettani és patológiai szerepei. A szerző bemutatja a sziálsav, a sziálsavtartalmú glikoproteinek, a sziálsavkötő struktúrák fontos funkcióit, együttműködését. Ebben hangsúlyos szerepet kap a sziálsavkötő Siglecek rövid tárgyalása, a patogén kiváltotta és steril károsodás, illetve inflammatio közös és kissé különböző volta. Kiemelkedő fontosságú a glikoproteinszerkezetű adhéziós molekulák egymással és az összes inflammatiós folyamattal kapcsolatos szerepe. A gyakorlati vonatkozások érintése kapcsán megfogalmazódik, hogy a szervezet ép struktúrájának, felépítésének és a védelmező inflammatiónak egyformán elementáris szerep jut az individuum fennmaradásában. Az életfunkciók sértetlenségének biztosítása, az ép szomatopszichés státus őrzése az inflammatio feladata. Ez a szervezet védekezőeszköze, és azonos a természetes immunválasszal, amihez elválaszthatatlanul hozzá tartozik a specifikus, adaptív immunválasz. Az inflammatio lényeges történései a kötőszövetben zajlanak. Orv. Hetil., 2014, 155(12), 453–460.

Open access

Mosca, M., Tavoni, A., Neri, R. és mtsai: Undifferentiated connective tissue disease: the clinical and serological profiles in 91 patients followed for at least 1 year. Lupus, 1998, 7 , 95–100. Neri R

Restricted access
Acta Physiologica Hungarica
Authors:
J. Lewin-Kowalik
,
W. Marcol
,
K. Kotulska-Wolwender
,
M. Larysz-Brysz1
,
E. Święch-Sabuda
,
D. Górka
,
B. Gołka
, and
E. Małecka-Tendera

The effects of the repair of nerve gap injuries are still unsatisfactory, despite the great progress in microsurgery. Until now, there is no effective method to induce the regeneration of the transected peripheral nerve when its distal stump is missing. The aim of this work was to examine whether the implantation of dead-ended connective tissue chambers can promote the outgrowth of injured peripheral neurites. This method differs from all previous nerve guides because it totally eliminates the distal part of the nerve and restricts the influence of surrounding tissues. We have also tried to establish whether some neurotrophic factors can be applied by means of these chambers. The results of this work show that dead-ended autologous connective tissue chambers can be a useful tool in peripheral nerve injuries treatment, even when the distal part of the nerve is missing.

Restricted access

Intramuscular connective tissue plays an important role in determining meat tenderness. The objective of the research was to compare the collagen/hydroxyproline content and X-ray Computed Tomographic (CT) connective tissue proportion of longissimus thoracis (LT) muscle in Hungarian Simmental bulls and cows. Animals (n=24) were slaughtered at similar live weight (bulls: 530.6+44.7 kg, cows: 527.3+53.5 kg) under standard commercial conditions in Hungary. After 24 h chilling, LT samples were taken from the right half carcass at the 12th rib. CT examinations were carried out with a 16-slice CT system (slice thickness: 5 mm). Samples were scanned at different user-selectable tube voltages e.g. low: 80 kV and high: 140 kV. CT value at LT muscle area of each mixed scan (80 and 140 kV) was determined. Volumetric connective tissue content was measured (above 200 CT value) as well. Following CT, the hydroxyproline/collagen content and intramuscular fat content of LT were determined. Cows had lower carcass weight (247 kg vs 295 kg), EU conformation score (3.5 vs 5.5), and fatness score (4.2 vs 5.9) than bulls (P<0.01). Bulls had higher LT area, but intramuscular fat content was similar for bulls (2.8±1.9) and cows (2.7±2.0). On the other hand, bulls had lower CT intramuscular connective tissue proportion in LT compared to cows (0.4±0.2% vs 0.7±0.3% P<0.01). The same tendency could be observed for the collagen content (0.5±0.2% vs 0.7±0.1% P<0.01). Correlation between the CT connective tissue proportion of LT and collagen content was r=0.8 (P=0.000). There was a weak positive correlation between slaughter age and CT connective tissue as well as collagen content of LT (r=0.3–0.4, P<0.05). In conclusion, intramuscular connective tissue proportion in LT increased with slaughter age, and older cows had higher collagen and connective tissue proportion than bulls. Mixed CT scans can be used for the analysis of intramuscular connective tissue content.

Open access

The investigation was carried out on 5 different muscles of 5 fattened bullocks of the Croatian Simmenthal breed aged 15 months and weighing about 400 kg and beefsteak tartare type products made of these muscles. Comparing the structure of the muscles used in the production of the beefsteak tartare, one may conclude that m. psoas major and m. longissimus dorsi are formed by dominantly white dynamic FG muscular fibres representing more than a half of all muscular fibres. In comparison with other muscles, the afore-mentioned muscles contain the least quantity of connective tissue. The investigations showed some statistically irrelevant differences (P?0.05) concerning the fibre diameters and volume density of connective tissue in m. psoas major and m. longissimus dorsi (L2

Restricted access

The aim of the present study was to investigate the serum and cerebrospinal fluid (CSF) concentrations of tumor necrosis factor alpha (TNF-alpha) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in patients with primary progressive form of multiple sclerosis (MS) and in patients with connective tissue diseases (CTDs) complicated with central nervous system (CNS) involvement. Stimulation of sVCAM-1 release by TNF-alpha was demonstrated on endothelial cells of brain vessels. We intended to present the TNF-alpha stimulated elevation of sVCAM-1 in the serum and CSF in any cases of CNS lesion. Fifty patients with several CTDs complicated with neuropsychiatric symptoms and 25 MS patients with primary chronic progressive form of the disease were selected. Determinations of TNF-alpha and sVCAM-1 were performed using ELISA methods. TNF-alpha and sVCAM-1 concentrations were elevated in the CSF of all patients, intrathecal synthesis of sVCAM-1 was demonstrated in MS patients. The changes in the TNF-alpha and sVCAM-1 concentrations were independent from the clinical manifestations, immunoserological changes and quality of neuropsychiatric symptoms of the CTDs. The stimulatory effect of TNF-alpha was more pronounced in the CSF of MS patients.

Restricted access
Orvosi Hetilap
Authors:
Fanni Virág Ralovich
,
Norbert Kiss
,
Krisztina Horváth
,
Sarolta Kárpáti
, and
Márta Medvecz

heritable disorders of connective tissue, Berlin, 1986. Am J Med Genet. 1988; 29: 581–594. 6 Mayer K, Kennerknecht I, Steinmann B. Clinical utility gene card for: Ehlers

Open access

213 Kovacs, E. J., DiPietro, L. A. (1994) Fibrogenic cytokines and connective tissue production. FASEB J. 8 , 854–857. DiPietro L. A

Restricted access

Pseudoxanthoma elasticumban szenvedő betegek multidiszciplináris ellátása

Multidisciplinary management of patients affected with pseudoxanthoma elasticum

Orvosi Hetilap
Authors:
Klára Farkas
,
Norbert Kiss
,
Viktória Szabó
,
Miklós Resch
,
Rita Vámos
,
Ágnes Borbándy
,
Anikó Nagy
,
Astrid Apor
,
Tamás Arányi
,
Flóra Szeri
,
Norbert Wikonkál
,
Zoltán Nagy
,
Béla Merkely
, and
Márta Medvecz

References 1 Vanakker O, Callewaert B, Malfait F, et al. The genetics of soft connective tissue disorders. Annu Rev Genomics Hum Genet. 2015; 16

Open access