volume assets more appropriately fit into a pilot plant infrastructure, which is often not as readily available or in short supply in manufacturing. Continuousmanufacturing (CM) offers a unique cost-effective solution to this problem since these products
Optimizing current chemical processes alone does not yield the improvements required in the fine chemical and pharmaceutical industries. At least partially, a switch from batch to continuous manufacturing is needed. Cost-, time-, and atom-efficient routes frequently demand the application of high temperatures, pressures, and concentrations, and/or the use of highly reactive reagents. These chemistries often cannot be employed in conventional reactors. Costly and long alternative synthetic routes are chosen instead. The application of continuous-flow microreactors allows to access “harsh” or “hazardous” reaction conditions and, furthermore, enables entirely new transformations.
Authors:Gregory A. Price, Debasis Mallik and Michael G. Organ
pharmaceutical industry where the increased potency of new active pharmaceutical ingredients (APIs) means that smaller quantities of drug are required to deliver the desired therapeutic outcome [ 1 ]. In addition, continuousmanufacturing limits the risk of large
intermediates/starting materials; – number of steps translated to continuousmanufacturing; – possibility to telescope the synthesis; – benefits obtained compared to the batch process; – multipurpose facilities.
A few additional comments should be added
continuousmanufacturing process in 2016 for Janssen's HIV-1 treatment drug Prezista [ 2 , 9 ].
Despite the growing importance of biocatalysis and microscale technology, merging of these two fields took much slower pace than implementation of
. Ponnappa , M. Collot , D. Kopetzki , D. T. McQuade , P. H. Seeberger * Organic Letters 2014 , 16 , 1794 – 1797 .
“ Development of a multi-step synthesis and workup sequence for an integrated, continuousmanufacturing process
Authors:Daniel Blanco-Ania and Floris P. J. T. Rutjes
Continuous processing has a long history in the production of chemicals at bulk scale. In fact, the majority of bulk chemicals is being produced in a continuousmanufacturing process. However, batchwise production
to continuousmanufacturing has been applied effectively by the pharmaceutical industry for small molecule drugs. Continuous applications for biologics manufacturing on the other hand have their limitations due to the complexity of automation and
, A. A. Kulkarni Organic Process Research & Development 2015 , 19 , 1138 – 1147
“ Oscillatory flow reactors (OFRs) for continuousmanufacturing and crystallization ” T. McGlone , N. E. B. Briggs , C. A. Clark , C. J
Authors:Gellért Sipos, Tamás Bihari, Dorottya Milánkovich and Ferenc Darvas
this can be done for any molecule, but the automated synthesis of specific compound libraries , active pharmaceutical ingredients , or even the end-to-end continuousmanufacturing of certain pharmaceuticals is indeed possible . Furthermore