Authors:Daniel Blanco-Ania and Floris P. J. T. Rutjes
be used for virtually any chemical reaction and are therefore cost efficient to operate. Nevertheless, since two decades or so, continuous-flowchemistry has become more widespread in academic synthetic chemistry groups that recognized the benefits of
Authors:Chi-Lik Ken Lee, Zhi-Yu Sem, Hendra Hendra, Xiaoqian Liu and Wei Lek Kwan
An ultrasound irradiated continuous-flow system was developed to accelerate chemical reaction by cavitation effect. Nucleophilic aromatic substitutions were performed, and the results showed that ultrasound irradiated is superior over generic heating in a continuous-flow system. The combination of micro-cavitation and flow chemistry synergistically enhanced the reaction yield and rate while maintaining the reaction at a much lower temperature.
Authors:Sara Sadler, Meaghan M. Sebeika, Nicholas L. Kern, David E. Bell, Chloe A. Laverack, Devan J. Wilkins, Alexander R. Moeller, Benjamin C. Nicolaysen, Paige N. Kozlowski, Charlotte Wiles, Robert J. Tinder and Graham B. Jones
A facile and benign route to N-heterocycles, including triazoles and triazolopyrimidines, has been developed. Using continuous-flow microreactor technology, organic azides are prepared in situ and reacted with cyanoacetamide in a [3+2] cycloaddition to produce a variety of substituted 1,2,3-triazoles, which can be elaborated into useful building blocks. A benzyl-substituted triazole was further functionalized to an analog of the core structure of the antiplatelet agent Brilinta®. The methodology lends itself well to flow chemistry, where reaction volumes are minimized, heating and mixing are consistent, and the need for intermediate azide isolation bypassed. The scope of the process is wide, and the efficiency is high, suggesting this as a practical, green route for the production of triazolo-based heterocycles.
ketones via nucleophilic Grignard addition to nitriles using continuousflowchemistry” C. Mateos ,* J. A. Rinc ón , J. Villanueva Tetrahedron Letters 2013 , 54 , 2226 – 2230 .
“Continuous process for click reactions using
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“ Continuousflowchemistry: a discovery tool for new chemical reactivity patterns ” J. Hartwig , J. Metternich , N. Nikbin , A. Kirschning , S. V. Ley * Organic & Biomolecular Chemistry 2014 , 12 , 3611 – 3615
Authors:Laurent Pellegatti, Andreas Hafner and Jörg Sedelmeier
This work describes the manufacturing of ribociclib following the concept of an end-to-end continuous-flow process. The active pharmaceutical ingredient (API) is produced in a two-step telescoped flow process with integrated in-line liquid—liquid extraction and semibatch crystallization.
Authors:Raquel A. C. Leão, Raquel de O. Lopes, Marco A. de M. Bezerra, Mauro N. Muniz, Bruna B. Casanova, Simone C. B. Gnoatto, Grace Gosmann, Laszlo Kocsis, Rodrigo O.M.A. de Souza and Leandro S. de M. Miranda
The use of continuous-flow chemistry has shown to be an important tool in improving API manufacture. In the present paper, we report the use of continuous-flow reactors in the synthesis of the bicyclic side chain of antiretroviral Darunavir.
In this section of the journal, the continuous-flow chemistry literature of the preceding months is presented. Included are articles published in the period October–December 2013 and January–March 2014. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed ordered by journal name, with review articles grouped at the end.
In this section of the journal, the continuous flow chemistry literature of the preceding months is presented. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed grouped by journal name, with review articles grouped at the end.
In this section of the journal, the continuous flow chemistry literature of the preceding months is presented. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed, grouped by journal name, with review articles grouped at the end.