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Commentary on: Chaos and confusion in DSM-5 diagnosis of Internet Gaming Disorder: Issues, concerns, and recommendations for clarity in the field (Kuss et al.)

Journal of Behavioral Addictions
Author:
Kai W. Müller

psychotherapy, the inclusion of Internet Gaming Disorder as a preliminary clinical condition in Section III of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5; APA, 2013 ) has to be considered not only as a justified but

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Nat Rev Microbiol 2 695 703 . 7. CA Borrebaeck 2000 Antibodies in diagnostics- from

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European Journal of Microbiology and Immunology
Authors:
Hans Kollenda
,
Ralf Matthias Hagen
,
Miriam Hanke
,
Sandra Rojak
,
Rebecca Hinz
,
Lars Wassill
,
Sven Poppert
,
Egbert Tannich
, and
Hagen Frickmann

, 28 ]. Based on the ongoing progress in the development of molecular diagnostic tools for malaria, organizations like the Société de Pathologie Infectieuse de Langue Française (SPILF) have recommended molecular tools [ 29 ] like LAMP as useful

Open access
Acta Physiologica Hungarica
Authors:
H. Pikó
,
V. Vancsó
,
B. Nagy
,
J. Balog
,
M. Nagymihály
,
A. Herczegfalvi
,
L. Tímár
,
Z. Bán
, and
V. Karcagi

Muscular dystrophies are a genetically heterogeneous group of degenerative muscle disorders. This article focuses on two severe forms of muscular dystrophies and provides genetic data for a large cohort of Hungarian patients diagnosed within the last few years by the authors.The Duchenne/Becker muscular dystrophy (DMD/BMD) is caused by mutations in the dystrophin gene, which is located on chromosome Xp21. The genetic analysis of dystrophin is usually performed by multiplex polymerase chain reaction (PCR), which detects approximately 95% of all deletions but does not distinguish between one and two copies of the exons investigated. The present work, therefore, concentrates on the improvement of the diagnostic panel for the analysis of DMD/BMD in Hungary. Radioactively labelled cDNA probes, encompassing the whole dystrophin gene detect all the deletions and the analysis is quantitative. In addition, the new multiple ligationdependent probe amplification (MLPA) technique was recently introduced that enabled more reliable and faster quantitative detection of the entire dystrophin gene. The genomic basis of facioscapulohumeral muscular dystrophy (FSHD) is associated with contraction of the D4Z4 repeat region in the subtelomere of chromosome 4q. In case of FSHD, molecular genetic criteria still have to be improved because of the complexity of the disorder.

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Adenoviruses are frequent infectious agents in different poultry species. The traditional, serological typing of new isolates by virus neutralisation tests is now in transition to be replaced by PCR and sequencing. The first PCRs, recommended for the detection of adenoviruses, had been designed to target the gene of the major capsid protein, the hexon. In birds, members of three different genera of the family Adenoviridae may occur. Accordingly, three specific hexon PCRs had to be elaborated for the detection of adenoviruses in poultry. A significantly more sensitive PCR, targeting the viral DNA-dependent DNA polymerase gene, has been described recently. This method proved to be an efficient alternative for the general detection of adenoviruses irrespective of their genus affiliation. Fowl adenoviruses (FAdVs), isolated from chicken to date, comprise twelve serotypes classified into five virus species (FAdV-A to E). The polymerase gene sequence has been determined yet only from three FAdV types representing three species. In the present work, the panel of polymerase gene sequences was completed with those of the rest of FAdVs. The newly determined sequences will facilitate the identification of new FAdV isolates as an existing species or as a putative new FAdV. Once the polymerase sequence is known, more specific PCRs for the amplification of the hexon and other genes can be designed and performed according to the preliminary species classification.

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Orvosi Hetilap
Authors:
Richárd Kiss
,
Szabolcs Kosztolányi
,
Ambrus Gángó
,
Károly Szuhai
,
Csaba Bödör
, and
Donát Alpár

–1194. [Hungarian] 10 Homig-Holzel C, Savola S. Multiplex ligation-dependent probe amplification (MLPA) in tumor diagnostics and prognostics. Diagn Mol Pathol. 2012; 21

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Healthcare, London, 2012. Brant, W. E., Helms, C. A.: Fundamentals of diagnostic radiology. Lippincott Williams & Wilkins, Philadelphia, 2007. Center for Devices and Radiological Health 2010

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. 2009 69 244 252 Vila, J. J., Vicuña, M., Irisarri, R., et al.: Diagnostic yield and reliability of

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Orvosi Hetilap
Authors:
Zsófia Simon
,
Ádám Jóna
,
Zsófia Miltényi
,
Edit Páyer
,
Attila Lieber
,
Mária Szilasi
, and
Árpád Illés

10 83 88 Váróczy, L., Gergely, L., Illés, A.: Diagnostics and treatment of pulmonary BALT-lymphoma: a report on four cases. Ann

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Az utóbbi 10 évben ugrásszerűen megnőtt az érdeklődés a kilégzett levegő és ezen keresztül a légúti gyulladás vizsgálata iránt a különböző tüdőbetegségekben. A gyulladás monitorozása segíthet e kórképek differenciáldiagnózisában, súlyosságuk megítélésében és a megfelelő terápia beállításában. Az új, noninvazív vizsgálómódszerek közül legismertebb a kilégzett levegő nitrogén-monoxid-koncentrációjának mérése, amely napjainkban nemzetközileg elfogadott ajánlások alapján a kereskedelmi forgalomban is kapható mérőműszerek segítségével történik. Az asztmás betegekben a kilégzett nitrogén-monoxid-koncentráció jelentősen emelkedett, és szoros összefüggést mutat a légutak eozinofilsejtes gyulladásával, a légúti hiperreaktivitás mértékével és a beteg panaszaival. E betegekben a kilégzett nitrogén-monoxid mérésén alapuló gyógyszeres beállítás a klasszikus kezelési stratégiákhoz képest jobb asztmakontrollt eredményezhet. Más tüdőbetegségekben, így például a krónikus obstruktív pulmonalis megbetegedésben a kilégzett nitrogén-monoxid mérése a szteroidra való válaszkészség megjósolásában segítheti a klinikust, míg tüdőtranszplantált betegekben rejtett infekciók vagy kilökődési reakciók indikátora lehet.

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