Authors:Z. Aigner, H. B. Hassan, O. Berkesi, M. Kata, and I. Erős
Summary Inclusion complexation between dimethyl-β-cyclodextrin and a very poorly water-soluble serum lipid-regulating agent, gemfibrozil, was studied. Products were prepared by several methods (physical mixing, kneading, spray-drying and ultrasonic treatment) in four different molecular ratios (2:1, 1:1, 1:2 and 1:3). The possibility of complex formation between the drug and the host molecule was studied by thermal analysis. Supplementary techniques, such as Fourier transformation-infrared spectroscopy and X-ray diffractometry, were also applied to interpret the results of thermal study of the products.
Authors:F. Taneri, T. Güneri, Z. Aigner, O. Berkesi, and M. Kata
γ-Cyclodextrin and dimethyl-β-cyclodextrin were used as solubilizing agents for a very poorly water-soluble drug, an imidazole
derivative antifungal agent, clotrimazole; with the aim of improving the physicochemical properties of the drug. Solid products
were prepared by physical mixing, kneading, precipitation and spray-drying methods in 1:1 and 1:2 drug:cyclodextrin molar
ratios. Drug interactions were studied by thermoanalytical methods such as DSC, DTA, TG and DTG, X-ray diffractometry and
Fourier transformation-infrared spectroscopy. The results demonstrated the formation of inclusion complexes in some products.