Authors:Thiago O. Carvalho, Ana E. B. Matias, Lilian R. Braga, Sheila M. Evangelista, and Alexandre G. S. Prado
), including diclofenac and dipyrone. These drugs should be highlighted due to their large consumption around the world.
The removal of these contaminants in the environment can be made by various physical and chemical processes such as photodegradation
Authors:A. S. Fonseca, J. N. G. Frydman, R. Santos, and M. Bernardo-Filho
) Limited-sampling strategy models for estimating the pharmacokinetic parameters of 4-methylaminoantipyrine, an active metabolite of dipyrone. Braz. J. Med. Biol. Res. 34 , 1475-1485.
Limited-sampling strategy models for estimating
Authors:Y. A. Ribeiro, J. D. S. de Oliveira, M. I. G. Leles, S. A. Juiz, and M. Ionashiro
Thermogravimetry, derivative thermogravimetry (TG, DTG) and differential scanning calorimetry (DSC), were used to study the thermal behaviour of mefenamic acid, ibuprofen, acetaminophen, sodium diclofenac, phenylbutazone, dipyrone and salicylamide. The results led to thermal stability data and also to the interpretation concerning the thermal decomposition.
Authors:Irena Baranowska, Piotr Markowski, Andrzej Wilczek, Magdalena Szostek, and Marlena Stadniczuk
Simple, rapid and selective NP-TLC and RP-TLC methods are described for analysis of l
-arginine, its primary metabolites (l
-arginine, agmatine, putrescine, spermidine, spermine, and creatine) and selected drugs (dexamethasone, prednisolone, furosemide, vancomycin, amikacin, fluconazole, digoxin, captopril, dipyrone, metoprolol, and sildenafil), in different therapeutic groups, in model solutions and in spiked human urine. NP-TLC and RP-TLC methods have been used to study the retention of the substances. A variety of mobile phase systems were evaluated for separation of ARG and its metabolites — methanol-50% acetic acid 3:1 (
) on silica gel and 5% acetic acid-methanol-acetonitrile 50:35:15 (
) on RP-18 — and for separation of the drugs — acetonitrile-water 2:3 (
) on silica gel. The effects on selectivity of the polar modifier of mobile phases were also studied.