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A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of functionalized 1,2,5-thiadiazepane 1,1-dioxide library, utilizing a one-pot elimination and inter-/intramolecular double aza-Michael addition strategy is reported. The optimized protocol in MACOS was utilized for scale-out and further extended for library production using a multicapillary flow reactor. A 50-member library of 1,2,5-thiadiazepane 1,1-dioxides was prepared on a 100- to 300-mg scale with overall yields between 50 and 80% and over 90 % purity determined by proton nuclear magnetic resonance (1H-NMR) spectroscopy.

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glycosylation of 3-deoxy-d-manno-2-octulosonic acid with batch and microfluidic methods ” A. Shimoyama , Y. Fujimoto , K. Fukase Synlett 2011 , 2359 – 2362 . “ Application of a double aza-Michael reaction in a ‘Click, Click, Cy

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