Authors:Z. Aigner, H. B. Hassan, O. Berkesi, M. Kata, and I. Erős
Summary Inclusion complexation between dimethyl-β-cyclodextrin and a very poorly water-soluble serum lipid-regulating agent, gemfibrozil, was studied. Products were prepared by several methods (physical mixing, kneading, spray-drying and ultrasonic treatment) in four different molecular ratios (2:1, 1:1, 1:2 and 1:3). The possibility of complex formation between the drug and the host molecule was studied by thermal analysis. Supplementary techniques, such as Fourier transformation-infrared spectroscopy and X-ray diffractometry, were also applied to interpret the results of thermal study of the products.
Authors:Genowefa Misztal, Łukasz Komsta, and Dorota Cichecka
values and mobile phase composition have been examined for six fibrate-type drugs — bezafibrate, ciprofibrate, clofibrate, clofibric acid, fenofibrate, and gemfibrozil. They were separated in horizontal chambers on RP18 plates by use of mobile phases containing phosphate buffer and different amounts of six modifiers — acetone, acetonitrile, dioxane, isopropanol, methanol, and tetrahydrofuran. Plates were visualized under UV irradiation at
= 254 nm, and scanned with a densitometer in multi-wavelength scan mode. Optimum modifier concentrations were also investigated on RP8 and CN plates for comparison. The linearity of relationships between
and modifier volume fraction, molar fraction, and the logarithm of the molar fraction was calculated. Most results fitted the
> 0.95; for almost half
> 0.99. Separation of all the drugs was achieved on RP18 plates with mobile phase containing 70% dioxane in pH 7.60 phosphate buffer.
values and mobile phase composition have been determined for the six antihyperlipidemic agents-bezafibrate, ciprofibrate, clofibrate, clofibric acid, fenofibrate, and gemfibrozil. The drugs were separated on silica gel, CN, and Diol plates using mobile phases containing
-hexane as weakly polar diluent and five polar modifiers: acetone, dioxane, ethyl methyl ketone, ethyl acetate, and tetrahydrofuran. The optimum mobile phases were also investigated on alumina, NH
, and polyamide phases for comparison. The linearity of relationships between
and modifier volume fraction, molar fraction, and logarithm of molar fraction was calculated. Plates were developed in horizontal chambers, visualized under UV irradiation at
= 254 nm, and scanned with a densitometer in the multi-wavelength scan mode. Most results fitted the
> 0.9; for approximately half
> 0.99. Separation of all the drugs was achieved on Diol plates with mobile phases containing 20–30% of each modifier in
-hexane, and with hexane-acetone, 9 + 1, on CN plates. Five drugs were separated using the same mobile phases on silica gel. The best separation was obtained on Diol plates with tetrahydrofuran-hexane, 2 + 8, as mobile phase.
Authors:Daniel Deme, Aref Al-Hadad, Tünde Varga, Erika Szántó, Katalin Sándor, and Ervin Rakonczai
R. P. Byrd Jr 2001 Simvastatin-diltiazem drug interaction resulting in rhabdomyolysis and hepatitis Tenn. Med. 94 339 – 341 .
. A. Tal M. Rajeshawari W. Isley 1997 Rhabdomyolysis associated with simvastatin-gemfibrozil