Authors:Suzanne Zorn, V. Molnár, F. Bíró, and A. Beregi
Gaschen, L., Ketz, C., Lang, J., Weber, U., Bacciarini, L. and Kohler, I. (1998): Ultrasonographic detection of adrenal gland tumor and ureterolithiasis in a guineapig. Vet. Radiol. Ultrasound 39 , 43-46.
Authors:Natalya V. Permyakova, Pavel A. Belavin, Dariya S. Pirozhkova, Elena G. Ufimtseva, Sergey M. Rozov, Sergey R. Mursalimov, Yuriy V. Sidorchuk, Elena A. Uvarova, Alla A. Zagorskaya, Tatiana V. Marenkova, Svetlana V. Bannikova, Evgeniy A. Demidov, Konstantin V. Starostin, Marionella A. Kravchenko, Diana V. Vakhrusheva, Roman B. Berdnikov, Natalya I. Eremeeva, Sergey N. Skornyakov, Sergey E. Peltek, and Elena V. Deineko
in a guineapig TB model.
The guineapig TB model is widely used to assess the efficiency of new anti-TB vaccine candidates [ 13 ]. Unlike the model that utilizes mice, which are apt to develop a latent TB variant, the specific feature of the
Authors:Fatema Moni Chowdhury, Mohammed Ziaur Rahman, Md Murshed Hasan Sarkar, Fazle Rabbi, Sirajul Islam Khan, Chowdhury Rafiqul Ahsan, and Nils-Kåre Birkeland
vaccine in the guineapig eye model against S. dysenteriae type 4 challenge. It also induced a high titer of serum IgG against S. dysenteriae type 4 whole cell lysate (WCL) and LPS. On the whole, DM104 could be a good choice as a live vaccine candidate
-induced contraction in rat and guinea-pig smooth muscles in vitro. Eur. J. Pharmacol. 281, 279-288 (1995)
Multiple mechanisms of bradykinin-induced contraction in rat and guinea-pig smooth muscles in vitro
Authors:L. A. Réthy, Magdolna Géresi, and L. Réthy
For lack of relevant data of the literature, the tetanus immunisation results obtained in the two sexes were compared in an animal model. Complete immunisation series of weaned, adult and aged guinea-pigs (20–25 animals/group) were performed with aluminium phosphate (AlPO4) adsorbed purified tetanus toxoid (PTAP) as well as with typhoid-tetanus vaccine (TY-TE) containing lipopolysaccharide (LPS). Both vaccines contained 5.0 Lf (limes flocculans, Ramon) per single dose of tetanus toxoid, purity degree: 1500 Lf/mg protein nitrogen (PN). Tetanus antitoxin titres (TAT) were measured after the first shot, and subsequently before and after booster. Compared to TAT of male animals, significantly lower titres were found in female animals after basic immunisation with PTAP in all the three age groups: 1.03 vs. 0.57, 8.75 vs. 5.64, and 0.27 vs. 0.15 IU (international units, related to the Copenhagen International Standard) per ml (sex-chromosome-dependent differences?), as well as in adult animals immunised with TY-TE, before booster: 0.07 vs. 0.02 IU/ml (hormone-dependent differences?). In the latter case the TAT results after booster were 14.49 vs. 12.89 IU/ml. Thus, the lower female prebooster titres were counterbalanced by a quick and effective increase of titres following booster. These results are in accordance with our previous observations in humans (Réthy and Réthy, 1986). From our observations with tetanus immunisation series on guinea-pigs it can be concluded that TAT may be influenced by the effects of sex chromosomes as well as of sexual hormones. During active anti-tetanus immunisation with LPS-containing vaccine (TY-TE) the lower adult female prebooster titres are presumably counterbalanced by the better functionality of the female immune memory.